PlantSME Plant secondary metabolism enzyme database
Terpenoid portable pathway

Terpenoid portable pathway

Category：Terpenoid pathway

Terpenoid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Terpenoid Reaction Route
MVA/MEP precursor branches to triterpenoid scaffolds, terpene scaffolds, and tailoring. Terpenoids draw IPP/DMAPP from MVA and MEP branches before prenyl extension and TPS branching; SQS/SQE/OSC form a triterpenoid/sterol precursor layer whose overlap with the steroid library is expected.
6 curated steps/modules
MVA And MEP Precursor Supply
01
Substrate
Acetyl-CoA
C23H38N7O17P3S
CH3-C(=O)-SCoA
Acetyl-CoA to IPP through the mevalonate branch
AACT29 HMGS36 HMGR98 MVK21 PMK8 MVD47
Product
Isopentenyl diphosphate
C5H12O7P2
CH2=C(CH3)-CH2-CH2-OPP
The MVA branch supplies isoprene units for sesquiterpenoid, triterpenoid, and sterol-related metabolism.
02
Substrate
Pyruvate + glyceraldehyde-3-phosphate
C3 + C3 phosphates
CH3-CO-COO- + OHC-CHOH-CH2O-P
Pyruvate/G3P to IPP/DMAPP through the MEP branch
DXS153 DXR26 MCT/IspD22 CMK/IspE25 MDS/IspF18 HDS/IspG149 HDR/IspH50
Product
IPP/DMAPP
C5H12O7P2
C5 isoprenyl diphosphates
The MEP branch mainly supplies precursors for monoterpenes, diterpenes, and plastidial terpenoids.
Prenyl Extension, Scaffold Formation, And Tailoring
03
Substrate
IPP/DMAPP
C5H12O7P2
C5 isoprenyl diphosphates
Isomerization and prenyl diphosphate extension
IDI219 GPPS14 FPPS240 GGPPS17
Product
GPP/FPP/GGPP
C10/C15/C20 diphosphates
prenyl-(C5)n-OPP
IDI and prenyltransferases generate GPP/FPP/GGPP substrates for TPS enzymes.
04
Substrate
FPP/squalene/2,3-oxidosqualene
C15/C30 precursors
linear isoprenoid precursor
Triterpenoid/sterol precursor scaffold formation
SQS/FDFT1 SQE OSC
Product
Triterpenoid/sterol precursor scaffolds
C30 scaffolds
cyclized triterpenoid scaffold
SQS, SQE, and OSC-family enzymes convert FPP-derived linear triterpenoid precursors into oxidosqualene cyclization products, forming a shared upstream layer for triterpenoid and sterol contexts.
05
Substrate
Prenyl diphosphates
C10/C15/C20
allylic polyisoprenyl-OPP
Terpene scaffold cyclization/rearrangement
TPS1286
Product
Terpene scaffolds
C10/C15/C20 hydrocarbons
cyclic/acyclic isoprenoid skeletons
TPS enzymes form terpene carbon scaffolds and act as central diversification points.
06
Substrate
Terpene scaffolds
C10-C20
isoprenoid hydrocarbon/oxygenated skeleton
Oxidation, glycosylation, and acylation tailoring
CYP71301 CYP761408 UGT3702 BAHD3639
Product
Tailored terpenoids
oxygenated/glycosylated/acylated terpenoids
terpene-OH / terpene-O-Glc / terpene-O-acyl
CYP/UGT/BAHD tailoring shapes polarity, storage form, and functional diversity of terpenoid products.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Basal angiosperms (11508)
Current lineage filter: Basal angiosperms. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits11508
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Brasenia schreberi
Annona cherimola
Cinnamomum kanehirae
Chloranthus sessilifolius
Piper nigrum
Cinnamomum camphora
Aristolochia contorta
Amborella trichopoda
Nymphaea colorata
Piper longum
Lineage Summary
Basal angiosperms
11508
Module Gene List
Reset
GeneSpeciesProtein ID
AtriAmTr_v1.0_scaffold001020208590.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001020208590.1
AtriAmTr_v1.0_scaffold001020208600.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001020208600.1
AtriAmTr_v1.0_scaffold001030208900.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001030208900.1
AtriAmTr_v1.0_scaffold001100215460.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100215460.1
AtriAmTr_v1.0_scaffold001100216150.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216150.1
AtriAmTr_v1.0_scaffold001100216170.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216170.1
AtriAmTr_v1.0_scaffold001100216180.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216180.1
AtriAmTr_v1.0_scaffold001100216190.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216190.1
AtriAmTr_v1.0_scaffold001100216200.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216200.1
AtriAmTr_v1.0_scaffold001100216210.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216210.1
AtriAmTr_v1.0_scaffold001100216220.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216220.1
AtriAmTr_v1.0_scaffold001100216230.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216230.1
AtriAmTr_v1.0_scaffold001100216240.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216240.1
AtriAmTr_v1.0_scaffold001100216250.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216250.1
AtriAmTr_v1.0_scaffold001100216260.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216260.1
AtriAmTr_v1.0_scaffold001100216270.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216270.1
AtriAmTr_v1.0_scaffold001100216280.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216280.1
AtriAmTr_v1.0_scaffold001100216290.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216290.1
AtriAmTr_v1.0_scaffold001100216300.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216300.1
AtriAmTr_v1.0_scaffold001100216320.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001100216320.1
AtriAmTr_v1.0_scaffold001110218040.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001110218040.1
AtriAmTr_v1.0_scaffold001140218850.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001140218850.1
AtriAmTr_v1.0_scaffold001140218930.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001140218930.1
AtriAmTr_v1.0_scaffold001170220550.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001170220550.1
AtriAmTr_v1.0_scaffold001170220760.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001170220760.1
AtriAmTr_v1.0_scaffold001170220780.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001170220780.1
AtriAmTr_v1.0_scaffold001210223110.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001210223110.1
AtriAmTr_v1.0_scaffold001330229620.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001330229620.1
AtriAmTr_v1.0_scaffold001360231300.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001360231300.1
AtriAmTr_v1.0_scaffold001360231310.1 amborella_trichopoda AtriAmTr_v1.0_scaffold001360231310.1