PlantSME Plant secondary metabolism enzyme database
Terpenoid portable pathway

Terpenoid portable pathway

Category：Terpenoid pathway

Terpenoid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Terpenoid Reaction Route
MVA/MEP precursor branches to triterpenoid scaffolds, terpene scaffolds, and tailoring. Terpenoids draw IPP/DMAPP from MVA and MEP branches before prenyl extension and TPS branching; SQS/SQE/OSC form a triterpenoid/sterol precursor layer whose overlap with the steroid library is expected.
6 curated steps/modules
MVA And MEP Precursor Supply
01
Substrate
Acetyl-CoA
C23H38N7O17P3S
CH3-C(=O)-SCoA
Acetyl-CoA to IPP through the mevalonate branch
AACT5 HMGS8 HMGR29 MVK16 PMK5 MVD10
Product
Isopentenyl diphosphate
C5H12O7P2
CH2=C(CH3)-CH2-CH2-OPP
The MVA branch supplies isoprene units for sesquiterpenoid, triterpenoid, and sterol-related metabolism.
02
Substrate
Pyruvate + glyceraldehyde-3-phosphate
C3 + C3 phosphates
CH3-CO-COO- + OHC-CHOH-CH2O-P
Pyruvate/G3P to IPP/DMAPP through the MEP branch
DXS18 DXR5 MCT/IspD5 CMK/IspE7 MDS/IspF5 HDS/IspG16 HDR/IspH5
Product
IPP/DMAPP
C5H12O7P2
C5 isoprenyl diphosphates
The MEP branch mainly supplies precursors for monoterpenes, diterpenes, and plastidial terpenoids.
Prenyl Extension, Scaffold Formation, And Tailoring
03
Substrate
IPP/DMAPP
C5H12O7P2
C5 isoprenyl diphosphates
Isomerization and prenyl diphosphate extension
IDI22 GPPS FPPS30 GGPPS
Product
GPP/FPP/GGPP
C10/C15/C20 diphosphates
prenyl-(C5)n-OPP
IDI and prenyltransferases generate GPP/FPP/GGPP substrates for TPS enzymes.
04
Substrate
FPP/squalene/2,3-oxidosqualene
C15/C30 precursors
linear isoprenoid precursor
Triterpenoid/sterol precursor scaffold formation
SQS/FDFT1 SQE OSC
Product
Triterpenoid/sterol precursor scaffolds
C30 scaffolds
cyclized triterpenoid scaffold
SQS, SQE, and OSC-family enzymes convert FPP-derived linear triterpenoid precursors into oxidosqualene cyclization products, forming a shared upstream layer for triterpenoid and sterol contexts.
05
Substrate
Prenyl diphosphates
C10/C15/C20
allylic polyisoprenyl-OPP
Terpene scaffold cyclization/rearrangement
TPS54
Product
Terpene scaffolds
C10/C15/C20 hydrocarbons
cyclic/acyclic isoprenoid skeletons
TPS enzymes form terpene carbon scaffolds and act as central diversification points.
06
Substrate
Terpene scaffolds
C10-C20
isoprenoid hydrocarbon/oxygenated skeleton
Oxidation, glycosylation, and acylation tailoring
CYP7176 CYP76145 UGT451 BAHD483
Product
Tailored terpenoids
oxygenated/glycosylated/acylated terpenoids
terpene-OH / terpene-O-Glc / terpene-O-acyl
CYP/UGT/BAHD tailoring shapes polarity, storage form, and functional diversity of terpenoid products.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Lycophytes/Ferns (1395)
Current lineage filter: Lycophytes/Ferns. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits1395
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Azolla filiculoides
Isoetes taiwanensis
Selaginella moellendorffii
Salvinia cucullata
Lineage Summary
Lycophytes/Ferns
1395
Module Gene List
Reset
GeneSpeciesProtein ID
ItaiItaiw_v1_scaffold_390260470.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_390260470.1
ItaiItaiw_v1_scaffold_390261070.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_390261070.1
ItaiItaiw_v1_scaffold_390261350.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_390261350.1
ItaiItaiw_v1_scaffold_400271510.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_400271510.1
ItaiItaiw_v1_scaffold_400271880.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_400271880.1
ItaiItaiw_v1_scaffold_400271900.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_400271900.1
ItaiItaiw_v1_scaffold_40264490.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_40264490.1
ItaiItaiw_v1_scaffold_40265290.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_40265290.1
ItaiItaiw_v1_scaffold_40265780.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_40265780.1
ItaiItaiw_v1_scaffold_40266030.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_40266030.1
ItaiItaiw_v1_scaffold_40267580.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_40267580.1
ItaiItaiw_v1_scaffold_40267870.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_40267870.1
ItaiItaiw_v1_scaffold_410275740.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_410275740.1
ItaiItaiw_v1_scaffold_410275750.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_410275750.1
ItaiItaiw_v1_scaffold_420277200.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_420277200.1
ItaiItaiw_v1_scaffold_420278160.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_420278160.1
ItaiItaiw_v1_scaffold_430279620.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_430279620.1
ItaiItaiw_v1_scaffold_430280360.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_430280360.1
ItaiItaiw_v1_scaffold_430280650.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_430280650.1
ItaiItaiw_v1_scaffold_430280670.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_430280670.1
ItaiItaiw_v1_scaffold_430280900.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_430280900.1
ItaiItaiw_v1_scaffold_430281680.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_430281680.1
ItaiItaiw_v1_scaffold_430282530.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_430282530.1
ItaiItaiw_v1_scaffold_440283930.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_440283930.1
ItaiItaiw_v1_scaffold_440284430.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_440284430.1
ItaiItaiw_v1_scaffold_440284450.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_440284450.1
ItaiItaiw_v1_scaffold_450285910.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_450285910.1
ItaiItaiw_v1_scaffold_450285920.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_450285920.1
ItaiItaiw_v1_scaffold_450286780.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_450286780.1
ItaiItaiw_v1_scaffold_450287010.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_450287010.1