PlantSME Plant secondary metabolism enzyme database

CpluGWHAMMO000009620294920.1 calohypnum_plumiforme

Protein ID: CpluGWHAMMO000009620294920.1
Record level: protein/isoform record
Species：Calohypnum plumiforme (calohypnum_plumiforme)
2
Assignments
Phylogenetic Position
Algae
Bryophytes
Lycophytes/Ferns
Gymnosperms
Basal angiosperms
Monocots
Eudicots
Annotation Path
Each assignment is summarized in the order Pathway -> Module -> Family -> Library -> Method.
Pathway Alkaloid pathway
→
Module Alkaloid portable pathway
→
Family TRI/TRII
→
Library Alkaloid Official Library
→
Method blast+hmm
Pathway Phenylpropanoid pathway
→
Module Phenylpropanoid portable pathway
→
Family CSE
→
Library Phenylpropanoid Official Library
→
Method blast
Annotation Details
Pathway Module Family Library Method
Alkaloid pathway Alkaloid portable pathway TRI/TRII Alkaloid Official Library blast+hmm
Phenylpropanoid pathway Phenylpropanoid portable pathway CSE Phenylpropanoid Official Library blast
Protein Sequence
MAADAGLTSSSWARGPHHQWGPMHSEGGVSGMQFSSEFEWISPSGRGLLTHYMPAHYSAGWWMDESTTVTEAEQACFELF
TELKKVALTRNVLLPVGTDYTPPNKWVTEIHRDWTARYTWPRFVCALPREFFAAVLAELDDRGQTPSPQTRDMNPIYTGK
DVSFIDTKQANRAAEDAVLDAEKFAVFAGLVGGADYPQAAMAKAWVQLAYGAHHDAITGSESDQVYLDLLTGWRDAWELG
RTARDNSLALLSSTIDADVVVWNTLAHSRTDVVTARFADPVGAHAQVLDADGVALPAVIEHGGRSVSWVARDVPSLGWRS
YRVVASDADSGWKSLEGNEIANEYYRLAVDPSRGGGVVSLVRDGKQLIGDGRVGNELAVYEEYPAHPTGGEGPWHLLPKG
PVVGSSDSAAQVQAYRSPLGGRLVIRGRIGELLRYTQTVTLWRGVDRVDCATTIDDFVGEDRLLRLRWPCPVPGAMPVSE
VGDAVVGRGFALLHNDSQSVDTADHPWTLDNPAYGWFGLSSAARIRVGDGVRAVSVAEVVAPSEASSGELARDLVVALVR
AGVTATCSSADRPRYGLLGVDSNLPDTRIALGRSAFTASVLAAADPAYAREVDRQLADTGRAVVWVPAAGSLADAWIPDA
DLRDASALPVLVIAGRDDAHLAAAIVSVVDDLADAEIEVEQQAPSGLLDFESRTVALCNRGVPSFAVETDGTLHTALMRS
CTGWPSGIWIDEPRRTAPDGSNFQLQHWTHTFDYALVSGTGDWRHAGIPERSAEFSHPLLPVTASGSLSGLPATGSLLAV
EPAGAVQVGALKAAGNPLAHGSAARVDPGHVALRLVETRGGEADVTVRSAFGTVSELRAADLLEQPKGRHPLTTLHGHQV
GTALARLDLPRLLDTENAPLAPDAEIAQPLYARYWLHNRGPAPLGGLPAVAHLHPHQLTAAAGSEVTLRLTLASDSTDAT
QTGTVSLVCAPGWTASPAALPFTLPAGEHLEADVAVTTPVGVEPGVYPVRAQLQVDDAAVPASWRQVVEDVALVSVGGAD
DGGLVYLTGEPTDVVVAAGDSARVTATVGNRAGADLSLEAHLISPWGTWDWIGPAVLGAVLPARGTVEVAFDVSPPAWIE
PGQWWALIRVGCAGRLVYTPAVRVDAREARLRDGPLASALPTVGTGEGRQLRRWLTQLIVTERVIALESEALGLAIDNAP
TEDDVLPDITARLEIGSIAAAALSDARARALFAHVTADIDVSDGEVAGYHHRNPLRFSGTRPVAHGWRAPAATVPPLAEV
APVIADHLRAAVRRRAFRVWLDKRRADLVHLAPDIGGTKIAVGLVDPAGELVHTAIEPTPKDQQAEHVWTVLHRMLTDTV
TVANGAVRGVGIGSAGPIDADAGTVSPVNIASWRGFPLRDRIAAAVPGVPVRLAGDAICMALAEHWRGAGQGARFMLGMV
VSTGIGGGLVLDGKPYHGRTGNAGHVGHVVVELDGEPCPCGGRGCVETVASGPWMTRWALANGWDGPAGADAVALGESAE
AGDPVAVQAFHRGATAVAAMIASVGAVCDLDLVVIGGGVAKSGALLFDPLRAALAGYAGLSFIRGLRVLPAALGADAGLI
AGQTRPHDHSRTCRCAGLSWVHHRPPGEQVGVGRVAMRAPTRTGSTSRAWDLRSGLDAARNRVPDTAARTRHGAQTPLSR
PDRILRRGVRRFRAEEPKEECMAQAEKATAVADIAEQFKSSTATVITEYRGLTVANLAELRRSLAGSATYSVAKNTLIKR
AASEAGVEGLDELFVGPTAIAFVSGEAVDAAKAIKKFAKDHKALVIKGGYMDGRALSVAEVEKIADLESREVLLAKLAGA
MKANLSKAAGLFNAPASQVARLAAALHEKRVAEEPAAADAPAAEAPELTLLELSEFVKKFEETFEVTAAAPVAVAAAGPA
AGGAPAEAAEEQSEFDVILEAAGDKKIGVIKVVREIVSGLGLKEAKDLVDGAPKPVLEKAPKEAADDAKAKLEAAGATVT
PGQHRPDRTALLAVGAGQFEHDEAVDRRPELRGGRYHRGLVVGGAVDPPGLHRPVHTAYDVGEAGVVVVDLGQAQREHVV
RRRIDAVRAGAAEHQPIQVRTFDRVAPISDSGRHQEPKVSNAVTAPPANPYLDDFLAPVSKEVTATDLPVTGRIPDFLDG
RYLRNGPNPVADVDPATYHWFTGDGMVHGVSLQGGKAGWYRNRWVRSAAVRKALGEPAAAGRPNLKAGMQSLGANTNVLA
HAGKTLALVEGGVANYELTDELDTVGACDFDGTLSGGYAAHPHRDPHTGELHAVNYSFARGKSVQYSVIDNNGHARRTVD
IAVSGSPMMHDFSLTEKYIVLYDLPVTLDPMQVLPKKMPRWMRRPAQIVADAVVGQLPVPGPLAAMFNRNEKSAYELPYA
WNPKYPARIGVMPREGSNGDVRWFDIEPCYVYHPLNAYSEDRNGQEVLILDVCRYDRMFDRDRRGPGGVIPTLDRWTINL
ATGAVASERRDDRSQEFPRINETLLGSKHRFGYTVGVQGGFVDSGRSKMLSALYKHDFSTGSSMVAPLDPELLLGEMSFV
PRPAADSASLAEDDGILIGYGYHRGRDEGQLVLLDAQTCESVATRIWEDVTMQIPQGEVSVLLGPSGTGKSVFLKSLIGL
LRPERGSIIVDGTDITECSAKELYDIRTLFGVMFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLDLVGLTGD
EKKFPGEISGGMRKRAGLARSLVLDPQIILCDEPDSGLDPVRTAYLSQLLIDINAQIDCTILIVTHNINIARTVPDNMGM
LFRRKLVMFGPREVLLTSDEPVVKQFLNGRRIGPIGMSEEKDEATMAEEQAHIEAGHHDGGTDEVEGVPPQVTATPGMPE
RKAAARRQARVRENLHLLPKQAQEAILESFEADKAGAAKNKSYDDAHPRHRDEDPDTASIPTQRARVRCWKECILAVSRQ
SKETPQSSTSSNSSVPGAPDRVSFAKLREPLEVPGLLDVQTDSFEWLIGAPRWREIAAARGDEKPTGGLEEVLYELSPIE
DFSGSMSLSFSDPRFDEVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVS
QLVRSPGVYFDDTIDKSTEKVLHSVKVIPSRGAWLEFDIDKRDTVGVRIDRKRRQAVTVLLKALGWTNEQIRERFGFSEI
MMQTLERDPTQNSDEALLEIYRRLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKINKKLGLSARPAETSSTTLTEE
DVVATVEYLVRLHEGQASMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQT
LINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHASHYGRMCPIETPEGPNIGL
IGSLSVYARVNPFGFIETPYRKVTDGVVTDEIQYLTADEEDRHVVAQANSPIDETGRFEEDRVLVRRKGGEVEYVSSAEV
DYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSESPLVGTGMELRAAIDAGDVVVADKAGVIEEVSAD
YITVMADDGSRHTYRMRKFARSNHGTCANQRPIVDAGERVESGQVIADGPCTDNGEMALGKNLLVAIMPWEGHNYEDAII
LSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTP
EERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDDDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIG
KILPVEDMPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGWVAKAGWNIEGSPEWAAALPEDLHTSQPDSIVATPVFDG
AKEAELQGLLASTLPNRDGDVMVNADGKANLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGG
KAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEGKG
SYVLDVNFFDELRIGLATAEDIRNWSFGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERC
GVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITAVDDEMRHNELSTLEAEMVVE
RKAIEDQRDSDLEARAQKLEADLAELEAEGAKADARRKVRDGGEREMRQLRDRAQRELDRLEEIWTTFTKLAPKQLIVDE
NLYREIIDRYGEYFTGAMGAESIQKLIENFDIDAEAEILRDVIKNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVP
VIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRP
LKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVER
QRPQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPQLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARIL
MLSSNNILSPASGRPLAMPRLDMVTGLYFLTTEIAGDKGEYTPAAKDQPESGVYSSPAEAIMAMDRGSLSVRAKIKVRLT
QLRPPAEIEAAQFGESGWRPGDAWVAETTLGRVLFNELLPVAYPFVDKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKD
AGFHWATRSGVTVSMADVLVPPNKAEILDAYEARADKVEKQFQRGALNHDERNEALVEIWKEATDEVGNALEAHYPEDNP
IITIVKSGATGNLTQTRTLAGMKGLVTNPKGEFIPRPIKSSFREGLTVLEYFINTHGARKGLADTALRTADSGYLTRRLV
DVSQDVIVRETDCGTERGILVELAEAGPDGTLIRDPHIETSAYARTLGADATDEAGNVIVARGEDLGDPQIEALLAAGVT
QVKVRSVLTCTTGTGVCATCYGRSMATGKLVDIGEAVGIVAAQSIGEPGTQLTMRTFHQGGVGEDITGGLPRVQELFEAR
VPRGKAPIADVSGRVRLEDGERFYKITIIPDDGGEEVVYDKLSKRQRLRVFKHEDGSERLLSDGDHVEVGQQLMEGSADP
HEVLRVQGPREVQIHLTKEVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGSLIERASFEAENRRVVAESG
EPAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAINCRSDKLQGLKENVIIGKLIPAGTGINRYRNIQVQPTEEA
RAAAYTIPSYEDQYYSPDFGQATGAAVPLDDYGYSDYRPQDPLATAAAENADVVQIFLGNPQSWKAPKPREDAAQLKAAA
LPIYVHAPYLINVASANNRVRIPSRKILQQTCDAAADIGAAAVIVHGGHVAEDTDLDEGFLRWRKALDRLETTVPVYLEN
TAGGDHAMARHFDIIARLWDHIGDAGVGFCLDTCHAWAAGEGLIDAVDRITAITGKIDLVHCNDSKDSAGSGRDRHANFG
TGQIDPELLVAVVKAADAPPKPPSGFVDGASIHAIGVSGQDRVYRLHKPTGLNGPASLVVVLHGGFGSAEQAERSYGWDQ
LADSSKFVVAYPDGVRRAWNVNGGGCCGKPAREHIDDVAFITAAVADISKHIGIDASRVYVTGMSNGGIMSYTLACDTTV
FAAIGPVAGTQLDPCRSPHPISVMAIHGTADPNIPYGGGEGHGFAHINGPAVPELNTLWRKIDQCQPPTETTDGQKKCNI
DGMPDTHVVSNQVPPLEDHNPASSPVLIEALIREGGQWGLDEVTAVGAISGARQTQRWGELAQRNRPILRTHDRFGNRID
EVEFDPAYHELMRTAIEHGLHAAPWADDRPGAHVVRAAKTGVWTAEPGHMCPISMTYAVVPALRFNSELAPIYEPLLTSR
EYDPELKLAITKVGITAGMSMTEKQGGSDVRAGNSAATPNGDGTYSLVGHKWFTSAPMCDIFLVLAQAPGGLSCFFLPRV
LPDGSLNRMRLQRLKDKLGNNANASSEVEYDGATAWLVGEEGRGVPTIIEMVNLTRLDCTLGSATSMRTGLTQAVHHAQH
RKAFGEYLIDQPLMRNVLADLAVEAEAATMVAMRMAGATDNAVRGDDTETLLRRIGLAASKYWVCKRATPHAAEAMECLG
GNGYVEESGMPRLYREAPLMGIWEGSGNVSALDTLRAMATRPECIEVLFAELAKSAGQDVRLDRHVEQLRPQLGDLETIQ
YRARKVAEDICLALQGSLLVRHGHPAVAEAFLATRLEGQWGGAFGTMPAGLDLAPIIERALVTDRVARITFNRPDKGNAI
IADTPLELSALVERADLDPNVHVILVSGRGEGFCAGFDLSAYADRTGSAGGTGAYSGTSLDGKTQAVNHLPNQPWDPMID
YQMMSRFVRGFSSLLYADKPTVAKIHGYCVAGGTDIALHADQVIAASDAKIGYPPTRVWGVPAAGMWAHRLGDQRAKRLL
LTGDCITGAQAAEWGLAVEAPDPDDLDERTERLVERIAAVPVNQLIMVKLALNSALLQQGVATSRMVSTVFDGVARHTPE
GHAAADLIRLTGDFDIKEATLRVALTRMVSAGDLVRSADGYRLADRLLARQRRQDDAMRPQLRPWRGSWTTLIVTSVGTD
ARTRAALRTTLQQKRFGELREGVWMRPDNLELDLDSDIGNRVRIVQAHDDDPAELAGQLWDLPAWARTGRRLLSDMSDAV
DIPDRFVTAAAMRQGPVTTVIIDRPGARNAVNGPTAAALFEAFDEFDRDDSASVAVLWGDHGTFCAGADLKAFGTPDANA
VHRTGPGPMGPSRMVLSKPVVAAVSGYAVAGGLELALWCDMRVAEEDAVFGVFCRRWGVPLIDGGTVRLPRLIGQSRAMD
LILTGRAVEATEALAIGLANRVVPKGQSREAAEQLALELSALPQQCLRSDRLSALHQWGLSEADALDHEFASIARVAAEA
NEECSTGLGDGVAAAEVVDLGLAVLVADGVVESDDVELGVDLVDSDLVVGAADAHRCAGALDRQRVVGADVVGEPLDGVA
PLLPLWAQPAIANVATAAAAKLSRPELYVRMPLTPDVADAIGHAELTPTVPDHRIAVLVEDRLVGAVDGDVVNDVVGDHG
VARSLHRYRPAGPERIDGVAGADHQQRRAIAVDGLLDALTGDVGIAILGRHTRSSGSAGEGDRDDAGRNGAAGDRPFHRG
FLSPRRAICWKEPTCSAEPESPAGRAGGARSGTRTARLSREIIVNAALTFLDREGWDALTINALATQLGTKGPSLYNHVD
SLEDLRRTVRIRVIDDIIGMLNRVGEGRARDDAVLVMASAYRSYAHHHPGRYSAFTRMPLGVGDDPEYTAATRAAATPVI
AVLSSYGLDLEQAFYAALEFWSAMHGFVLLEMTGVMDDIDTDSVFSDMVLRLAAAGPQGSPRQGREGQDRGPQGQPAAPR
GVHPRIHHDAEEAELGAPEGRACEADHGCRGHRLHPGRGSQPAGALDGAGARRSCEGPARCAVQDHPWLAGHPGCQVPQA
GPQPLRRQEGEELMPRKGPAPKRPLVNDPVYGSQLVTQLVNKVLLDGKKSVAERIVYGALEQAREKTGTDPVVTLKRAMD
NVKPALEVRSRRVGGATYQVPVEKDVLTDLTKVRNIGIMAHIDAGKTTTTERILYYTGISYKIGEVHDGAATMDWMEQEQ
ERGITITSAATTCFWNDNQINIIDTPGHVDFTVEVERSLRVLDGAVAVFDGKEGVEPQSEQVWRQADKYDVPRICFVNKM
DKIGADFYFSVKTMEDRLGANVIPIQLPVGSEGDFEGIVDLVEMKAKVWRGETKLGETYETIDIPAELQEKADEYREKLL
EAVAETDETLLEKHFGGEELTIDEIKAALRKLTISSEAYLVLCGSAFKNKGVQPMLDAVIDYLPSPLDVPPAEGHVPGKE
DELITRNPSTDEPFSALAFKVATHPFFGKLTYVRVYSGKVDSGSQVINATKGKKERLGKLFQMHSNKENPVETASAGHIY
AVIGLKDTTTGDTLCDPNDQIVLESMTFPDPVIEVAIEPKTKSDQEKLSLSIQKLAEEDPTFKVHQDNETGQTVIGGMGE
LHLDILVDRMRREFKVEANVGKPQVAYKETIKRAVDKVEFTHKKQTGGSGQFAKVLVSLEPFSGEDGATYEFENKVTGGR
IPREYIPSVDAGAQDAMQYGVLAGYPLVNVKLTLLDGAYHDVDSSEMAFKIAGSQVMKKAAAQAQPVILEPIMAVEVTTP
EDYMGDVIGDLNSRRGQIQAMEERSGARVVKAHVPLSEMFGYVGDLRSKTQGRANYSMVFDSYAEEDTEVAKAKFERTKP
HVNIGTIGHVDHGKTTLTAAITKVLHDKYPALNESRAFDQIDNAPEERQRGITINISHVEYQTEKRHYAHVDAPGHADYI
KNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKSDMVDDEELLELVELEVRELLAAQEFDEDAPV
IQVSALKALEGDPKWVESVEKLMDAVDESIPDPVRETDLPFLMPVEDVFTITGRGTVVTGRVERGVINVNEEVEIVGIKP
TSAKTTVTGVEMFRKLLDQGQAGDNVGLLLRGIKREDVERGQVVVKPGTTTPHTDFEGSVYILSKDEGGRHTPFFNNYRP
QFYFRTTDVTGVVTLPEGTEMVMPGDNTEISVKLIQPVAMDDGLRFAIREGGRTVGAGRVTKIINTTALTRKGGRRLRYA
LARPAMRCPAPSIFSTTGFLMLARYLKAQLLVLVCGGLVGPIFLITYFVLPGMMGNQFDSIDSSISSTIQQSTSWLLWVG
AFITIADVFVALWLANRGAQSSAKMAALQQTGVMTTAQISGMAETGMRINDHPVVNLDLHIAGPGFDFTDRKRVTVDFAK
QAIVTARKLVVLVDPTTHSYEIDWQASALLGGVVPAQITVSEDNKTYDLSGQAGPLMEILQIYKANNLPFGGTVDIRNYP
AVRQQVLAVVRRAGADQHPAPVGGGVSDRLEELQKLHASGAISDAEAHAARLAREGADIIALDICAPVSDTITYAAATPE
DLTETVRAVEAEGRKILARQVDTRDDAAVRQLVADGVEEFGRLDILIANAGVLSWGRVWELTDEQWDSVISVNLTGTFQT
VRAVVPAMIDAGNGGAIVVVSSSAGLKATPGNGHYSASKHGLTGLTNSLAIELGEYGIRVNSIHPYSVETPMIEPDLMMQ
VFGKHPHFIHSFGPMPLQPHGFMGAAEVSDVVVWLVSDAAGTLTGAQIPDAAVGQSQAELLAGAERGVDVDTGPQPSPTH
LQHAAADQPVQPHVQMLPELRCTLLEFAAGQHRHHGAADCRRERVAAERRAVLAGVQHSEDVTIGHHRRQRNHATAQCLA
EQIDVGHHGPVIAGECPPVVVRDHNIGQTGGHPFDVGAPLAGDLECALDRLGTAVHRQHHVLVAQRRKTRAEQAQGFGVE
CPADQRHPVELGMRGRGDLRVAVPEVHRRVGGQAVQLDTDRFETCFAQLPGEADGGGGVDYVASVRDGVQAERVGVGGVD
DDRIGEQGLQVRTGHVGEGRGIVGDRRVIEHGQRGVEVVEARIDQFEADHPPIEDPGDLAVCPQIGAEAVAGQDVVAHRQ
QVALAFVDVTCLPGPETLRRQPRSVGGRFRFALSVFEACDRRGAVDDQPTVGGVDHVGQTRDRIDQIDAVSQLDVDVLEL
LPLRQRGRRVDGSRSVHPGIDRVGDLEELRWSHYVVPNAGLALGGLTARCGFDFREGRHKTTNGMIRVSVVPGGMMNRMD
DLDELILAELGQHARATFAEIGERVRLSAPAVKRRVDRMLESGVIQGFTTVIDRNAVGWKTEAYVQVFCHGRISPSELRR
AWVDIPEVVSAATVTGTPDAILRVLARDMPHLEDALERIRTSAAVERSESIVVLSNLIDRSRAQGSGDNGIVIVGGGLAA
TRTAEQLRRANFEGPITIVSDEVHLPYDRPPLSKEVLRSEVDDVTLKPREFYDEQNITVRLGSAATGVDPGAQTVTLDDG
STLGYDELVIATGLVPRRIAAFPDLEGIRVLRSFDESLALREHASEAHRAVVIGAGFIGCEVAASLRRMGVDVVLVEPQP
APLAAVLGEQIGGLVARLHRDEGVDVRTDVGVADVRGDKHVETVEFTDGTEVNADLVVVGIGSRPATDWLEGSGIEVDNG
VICDAAGRTSAPHVWALGDVASWRDARGHQVRVEHWSNVADQARAVVPAMLGQEAPSTVVVPYFWSDQYDVKIQCLGEPV
ATDTVHIVEDDGRKFLAYYERDGAVSGVVGGGMPGKRKVLPHNRMPQHGEGAVDEPEPRHRFGGIAAVQGGRHLTGDADR
AVQPVEPGRLVGPDVAQQRHLALGAGGVQRGDVVAVAFDDAQLGSRRQVATPGVFDGHRRISRTPVTPRMEIPVMVGPQI
QPGAAADLEKSYRQTESVGQRQQAADQRGGAADLVGLRRLVERSTQILDMIRGGLQDVGPGRLAVPFPADTGIPASQRGG
PAVERQPTAAHRRAACPDQHRPAAHSGAGGERRSLPTESRSSMRSSETRCDGRYRRPVRRRRRSPPRTRVRRTTRSRHPR
CAPAWWSGGGRPVAAAAPSAPPFHSGTRCHILTEILTTSTRLVETRPNERQRHGAEPADRHRNRARHRDPGRRGVHRRDV
RGLLTVSAPTQGLDGPPASSAGGRTEFDLDAAWRLHPQVAVRPESFGALLYHFGTRKLSFLKNRTILTVVQSLDQFSDVR
AALGAAGVEDSQLDPYVHALGVLAGSHMVFEHGLDAPICLTWELTYACNLSCVHCLSSSGKRDPRELSTQQCKDIIDELE
RMQVFYVNIGGGEPTVRPDFWELVDYATAHHVGVKFSTNGVRITPEVATRLAASDYVDVQISLDGATAEVNDAVRGTGSF
AMAIRALENVAAAGFKDAKISVVVTRHNVDQLDEFASLASRYGATLRITRLRPSGRGADVWDELHPTSDQQVQLYDWLVA
KGDRVLTGDSFFHLSGLGEPGALAGLNMCGAGRVVCLIDPIGDVYACPFAIHDRFLAGNVLSDGGFDTVWKDAPLFRELR
EPQSAGACGSCGHYDSCRGGCMAAKFFTGLPLDGPDPECVQGYGVPALAQERDKPRPAGDHSHGKRKSGPVPLTLTVPSR
STPRKLCNESPQRAKKRLPKSSYSALVSASEKGVTVSDNVEAFGELGFAPHVVGALEKRDLATTIMGQEISLPVIISPTG
VQAVDPDGEVAVARAAAARGTAMGLSSFASKPIEDVIAANPKLFFQVYWSGGRDVIAARVERARQAGAVGLIVTTDWSFS
HGRDWGSPKIPEQMNLRTMLRMSPEVITRPGWLWRFGKTLRPPDLRVPNLAGRGEAGPPFFAAYGEWMTTPPPTWADIAW
LRELWGGPFMLKGVMRIDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAVAEAVGDQVEVLLDGGIRRGSDVVKAL
ALGARAVMIGRAHLWGLAAAGQPGVENVLDIMHSGINSALMALGRASVHDLNRDDVLVPDGFTRTLGAPAGDASSLERAA
GKTFSIAPTTNARQVNSSYHHRVVVQPDLGGSTSSQLQSMPIGLAIPVGSTEQHGPHLPLDTDTRIASAVATAATAELSA
DPELMWLAAPAIAYGASGEHQSFAGTISIGTDALTTLLVEFGRSATCWAQRLLFVNGHGGNVGALDRAVALLRSEGRDVA
WSPCVVAGGDAHAGHTETSLLLHISPADVRTDRWRAGNSSPLAELLPSMRSGGVAAVSEVGVLGDPTTATAADGERMLDE
MVDRRVRVLGQGSALLGGSPTRILRLAPAAQDMLADGRLKVRDAVSAELARTLLDATVAHPRPAGGPSHRDVTIVIPVRD
NASGVRRLVASLRGLHVVIVDDGSSTPIRPEDFVGAHTDIDIIRHPQSRGPAAARNTGLAACKTGYVAFLDSDVVPRRGW
LEALLGHFCDPTVALVAPRIVGLAQTDHLVARYEAVRSSLDLGQREAPVIPYTSVSYVPSAAIICRTTALREIDGFDETM
RSGEDVDLCWRLVEAGARLRYEPIAQVAHDHRTDVRDWVARKAFYGGSAAPLSVRHPDKIAPLMISGWALAAWTLMAFGS
SFGYLASLFVAGLTGRRVAKSMQGTETQIWDVVMVAARSLWSAALQLASAICRHYWPVALLAALLFRSCRRVVVVAAVVD
GVVDWANRRDVADDDARPIGLLTYLLLKRIDDLAYGLGLCDVLIIGAGSAGSVVANRLSANPNRSVTILEAGPGLSDPAL
HAETGNGLRLPIGAVSPLVERYQTRLTDEPARHMTIMRGATVGGSGAVNGGYFCRGLPRDFDDFGVPGWGWSDVIDHYRA
IETDLDFTGPAHGQSGPIMVGRTREIVGSTATFVDAARRHGFDWLPDLNDVADADALPSGVGAVPLNIVDGTRIGPGAAF
LLPALDRPNLTLLTQTRAVGLRLSRGRATGVDAVGAAGAVTLTADRIVLCAGAIESAHLLMLSGVGDEAMLRAAGVKMVA
RLPVGMAFSDHPEWVLPTTWAVATRRPVLEVVLSTPDDVEIRPYTGGFVAMVGDGTPGHPDWPHLGVALMRPKARGRITL
VSGDPLVPPLIEHHYDREPVDIAALRAGCRLAREIAAPTTEVGESAWSTSQHLCGTAPMGGADDPGAVVDHQCRVHGIDG
LWVIDGSEVVRIADKTDPRPARSRARLLEAATALLRAGGPSAVTVDAVTRGANVARATLYRHFPSGNDLLAAAFGSLIPP
APMPSNEGSLRDRLIALVLAFGQSIAERPGMAMAMSWLALGRDLEQLPESPRARTSDSPAVTTLRERIAQQYAAPFDAIF
DSSDAAVLGDINRSRAIALLIGPVVLGRLSTLPDFDYRECARAAVDGFLHVLETADERRRDQLRIPVQFNRFESREQLGE
EAVHLHPGQCRAQTEVHPVAERQVLVGVASHVESKRVGEHLFVPVAGDVGQINRLAFGDRYAANRGVGGGGAHELLDRRH
PADHLLDGQWHQIKVVGQPFSLIRVLDQGLQPAGDRGAGGVVARGGDDHVIRDGVDVGQRFAVDSGVGDRRGQVVGRMLA
ARRGQCGEVAEEVEQDLELLLECGATFELVVVAAEQFLRQRQHPGEVRLRQAQQRHDHVQRVIHGDLLHEIALVARSQHL
VDVDLGQFVDANLQRAHCLGAEPVRADRANHAVLGVVHVDQGAQPHAGLQLLTRHVVGLCGGQQRTRLVDEEVVGPLDVQ
DVGVLGDRPERPVGRVVDQRDRCVGAQMGQRRMQPRFVGIRRRIRENCCGLVRDRCAHLPTHLPGCCLVSIRSPRRRRVW
AALLVTALLAGACGQDAGVKPRKAEPAFAGPLDGGVVRTAMGSIRGQVAADYRVFQSIPYATPPVGPLRWQLPRPPARWP
GMLDATKSGPQCMQDTGLKPGVGKPTSENCLTLNVWTPPRAQHGEKRPVMVWIHGGGFVQGSGDIYHSRWLAAKGHIIVV
TVNYRLGALGFLAHPSLGPAGAIGNYGLADQQAALRWVRDNIAAFGGDPKKVTIAGESAGGMSVCDHLIAPGSAGLFRAA
IIQSAPCQAQTDLEFGQRQSVDYAIAAGCRNPATTARCLRALPATRLERPPWYYFLGDSDALSGPVTGTPTLPDNPVAAF
AAGGAARVPVLMGVNHDEFTLFAALRAARLKRGVSPGEYPRVLADIFGDDSGPVLEHYSPDRFGGDVSLAYSAAATDGVF
ACTTDRLADSLSRGAPVYAYEFNDPRAPAPDFLRHAPFPAGASHSLELRYLFSMGGAPPLDRAQQILSDQMMSYWSHFVT
NGTPKVAGLPDWPAQDGDPEHNYWMSLRPGGSQAVSTPDPRGFAEKWAAAWNLRDVEAVLSHFHDDVVFTSPVAAGVVPD
SGGVVSGKMALREYWCAALAAVPDLHFDLVGVYTGVSTLVINYRNQNGGLVNEVLEFDGERVVVDEEPLGHPHLGQSRFH
PDHVRQHRGEVRPSWRPTLLWSKKCLSETTRALRDRFGPYRDLGHTVRVALSRVHAWPGVRPAPTTGASGPILERDQFRS
RTRLREGDTPDRGGRWTKTGELRAMARKGILGTKLGMTQVFDENNRVVPVTVVKAGPNVVTRIRTPEVDGYSAVQLAYGE
ISPRKITKPLAGQYAAAGVNPRRHLAEFRLDDEAAAADYEVGQELTAEIFAAGTYVDVTGTSKGKGFAGTMKRHGFKGQG
ASHGAQAVHRRPGSIGGCATPARVFKGTRMSGRMGHDRVTTQNLLVHLVDAENGVLLIKGAVPGRTGGLVVAIKIDVKTP
AGATEGSVELPAALFDAPANIALLHQVVTAQLAAKRQGTHATKTRGEVSGGGRKPYRQKGTGRARQGSTRAPQFTGGGVV
HGPQPRDYSQRTPKKMIAAALRGALSDRARNGRIHAVTELVSGQTPSTKSAKAFLGSLTEGKQVLVVIGRSDETGAKSVR
NLPGFGLMATVTDPRDIILAPVISEKSYGLIDDNVYTFLVHPDSNKTQIKIAIEKIFAVKVSAVNTANRQGKRKRTRAGF
GQRKSTKRAIVTLAPGSKPIELFGNTAVSDFAEITRSTPEKSLIKPLHGKGGRNAHGRITTRHKGGGHKRAYRVIDFRRN
DKDGVNAKVAHIEYDPNRTANIALLHFLDGEKRYIIAPQGLSQGDVVESGANADIKPGNNLPLRNIPAGTLVHAVELRPG
GGAKLARSAGSSIQLLGKEGTYASLRMPSGEIRRVDVRCRATVGEVGNAEQANINWGKAGRMRWKGKRPTVRGVVMNPVD
HPHGGGEGKTSGGRHPVSPWGTHQGRPEGEAAMSTATEFPSATAVARFVRVSPTKARRVIDLVRGKSVTEALDILRWAPQ
AASEPVAKVIASAAANAQNNNGLDPATLVVATVYADGGPTAKRIRPRAQGRAFRIRKRTSHITVIVESRPSKESRGAQSA
SAARARRAQASKAAGGLRLVGQKINPHGFRLGITTEWKSRWYADKQYADYIKEDVAIRKLLSTGLERAGIADVEIERTRD
RVRVDIHTARPGIVIGRRGTEADRIRTDLEKLTGKQVQLNILEVKNPESTAQLVAQGVAEQLSNRVAFRRAMRKAIQSAM
RQPNVKGIRVQCSGRLGGAEMSRSEFYREGRVPLHTLRADIDYGLYEAKTTFGRIGVKVWIYKGDIVGGKRELVAPSAGA
ERPRRERPSGTRPRRSGSAGTTATSTEAGRAASSAEETTTAAPTEAPAVEAQTGSRALRAQLPQRADRPGSIDPCDPQAA
DQGTHRYPRGSVLMAVGTSPGELRELNDDELIEKLREFKEELFNLRFQMATGQLANNRRLRTAKKAAPAKTAAPAKDASA
KGPKHTPATPKPRGRRKTRIGYVVSDKMQKTIVVELEDRMRHPLYGKIIRTTKKITDGQADRAEARDGRAQHTEVLPQRG
LAADDASDDRQHQQHRGRHPDELVQSAGEVREAVADRDADRNGYQHHRDDAEELVELQWNETSFAEKPGQGEGQDRGYRD
DGQHRVDRREREIERQVAVREMTDDVRQHSTRGRRHQHQPDGQVGRQAQPLGDQQAERGQDQRLTDQRNQQWAPYRRSPA
EVVDGQREPEGEHDCADDQRQEPRWLSCRKSSPSEVRLRPVLRRETSTRVGYVANQPFPCARDQTIEGVAVMTLRVVPEG
LAAACSGVEALTARLAAAHAVAAPLITGVIPPAADPVSLSSAAEFSVRGELHAAVAAQGVEELGRAGVGVGESGVSYASA
DAAASSAYFAAGPSAESFLAANAPFLAWLNQASSDSAAAAAQHETLAAAHTAALAAMPTLPELATNHVVHGALVATNFFG
INTIPIALNEADYARMWIQAAATMGTYQAVAGSAVAATPVTEPAPPILKSDSQTAAAPADTTTETPLDQLIVQFLQARGI
TWDPTAGTINGLPYSSYTNPLTTLYWVKNTVTLVQDLENFAQLLATNPQAALASLTPANIVAFLVAHPVVAAAIAASSAT
TVLPAAAAAAVASVAAVVGLIDPSLFQPFLPPLPPIAALPILPSVASTPLAAATVAPTAPAPSAPAAPAGSTATGSAPAP
PSPPPATAHGLPLPYPIFTGGGPPIGFDSGTKSSVSSSARLKAPAESAGAAAASAARKRSRKRRAQQAHKYDYADATMNY
GVISDPSEPPLPSTAASDSGGGPLGFAGTRAEHTDAAAHLDARPVLAVRCDVGREFGTWVYSASGILGGHNESEARMASE
FNGKIELDIRDSEPDWGPYAAPTASEGAPNVLYLVWDDTGIATWDCFGGLVEMPAMSRIAERGVRLSQFHTTALCSPTRA
SLLTGRNATTVGMAMIEEFTEGFPNSNGRIPFETALLSEVLAEQGYNTYCVGKWHLTPLEESNLAATRRHWPTSRGFERF
YGFMGGETDQWYPDLVYDNHQVSPPATPEDGYHLSKDIADKTIEFIRDSKVIAPDKPWFSYVCPGAGHAPHHVFREWADR
YAGKFDMGYERYREIVLEQQKSLGIVPQDTELSPVNPYLDVKGPNGEPWPLQDTVRPWDSLTDEEKKLFSRFAEVFAGFL
SYTDAQIGRILNYLEESGQLDNTIIVVISDNGASGEGGPNGSVNEGKFFNGYIDTVEESMKVFDHIGGPETYNHYPIGWA
MAFNTPYKLYKRYASHEGGIADTAIVSWPKGIAAHGEIRDNYVNVCDVTPTVYDLLGVEPPAAVRGVPQKPLDGVSFKAA
LDDSSAATGKETQFYTMLGTRGIWHDGWFANTVHAATPAGWGHFDADRWELFHIEADRSQCHDLAAEHPDKLEELKALWF
SEAAKYNGLPLSDLNLFETLTRQRPYLSGERNSYVYYPDCADVATGAAVEIRGRSFAVLADVTVDSTGAEGVLFKHGGAH
GGYVLFVQDGRLHFVYNFLGERQQEVASSAAVPLGRHVFGVRYERTGTVENSHTPLGDVTLFIDDATVGTLAGVQSHPGT
FGLAGAGITVGRNGGSAVSSRYKSPFVFSGGTIAQPFRVTELSPRVLWAALAAVGVLSGCVRSIDGTAAWTGVSSAPAAP
TTGNAAPAPGIETTIPDHIPPNALLCFPGPAEGGIGTVAQVVAHAAPRLTVTVPDGWSSEPGHEDVALSLSGPDGMTGLV
TIAATKLDPARAFSDYAATLAHSKSDFHVETLGAKFCGYSSQKLVGTFGGPSSTVEFADRLTHIWTNTDQYLVAIHLEGP
EDTPGFYAEEAPIHTVRVDAFAIERHPVTNAQFAEFAHATGYVTVAEQAIDPALYPGADPAELQPGAMVFRPTSGPVDLR
DWRQWWAWVPGACWRHPFGPGSDIADRADHPVIQVAYPDAAAYARWAGRRLPTEAEWEYAARGGLAATYAWGEQEKPDGV
TMANTWQGSFPYRNDGWAGTSPVGSFPPNGFGLFDMIGNVWEWTTTQFSAHHRLDQPPKSCCAPTGPADPSIAQTLKGGS
HLCAPEYCHRYRPAARSPQSQDTATTHIGFRCVSDLRALDRHADLRVGVLRADDLVGRHHDRIHVVLTGVVERREVEHQV
VALADDLGAGDGDRARGVLHRGGGAVVAFGAGSGAALEILAGALGPDAGGGRLQRGDRRVVPAGDVAVEDACHGLGVEHQ
EVDRQVVGDGQRAENHRQVPRLGAPAALLGGGGLVVAERDVRSDEIALAGKEVGDTGARTVGGVVQAVAGAGLAVGADES
LHRVGLCGGATGRDRRLAATGHDFARTPSAVSAPTPDRDRRRPRIVIGVAILMAVVAAYGLSLYGVHLLQKSEGPLPPLD
LSQAAADETVVQIRLEELKPTTNRLTVNVLIYPGESLEDKRFDELNTDIAVRLYPPNDLGDLKYPAGKAPAQVSTTIQAY
GDPGAWPFDSYRSEPISADVFVGNGAERKRLPARVQVTGAMDGWDATTKLNSDSSETGSHNTSNVVVTLHRAKGPLIFDL
GIILVLISLPTLALVVAIPMAMGRRKFVPPFATWSGDRVIQQESRLKVADNTGAKEILCIRVLGGSSRRYAGIGDVIVAT
VKDAIPGGNVKRGDVVKAVVVRTVKERRRPDGSYIKFDENAAVIIKPDNDPRGRQPDQEAHRDLVERARRAVRRHRHAGS
PHPRLQRDGGRLRRRRHPDRLPGRRGDRQAGSDLQAQRQGHRGMTTTEQEKVQPRLKARYRDEIRDALNKEFAYANVMQI
PGVVKVVVNMGVGDAARDAKLINGAVNDLALITGQKPEIRKATKSIAQFKLREGMPIGARVTLRGDRMWEFLDRLISISL
PRIRDFRGLGSKQFDGRGNYTFGLTEQSVFHEIDVDNIDRPRGSACVRWRMRVNCPVWRRAAGNRQQQNITPTRKERSDE
EEQRSMTMTDPIADFLTRLRNANSAYHDEVTLPHSKLKANIAEILKREGYITDYQTEDARVGKALKVQLKYGPSRERSIA
GLRRVSKPGLRVYAKSTNLPRVLGGLGVAIISTSSGLLTDRQAARQGVGGEQPIQIPSGVEVAIDGQQVSVKGPKGTLDL
KVSEPITVARNEDGAIVVNRPNDDRHSRSLHGLSRTLVSNLVVGVTQGYTIKMEIFGVGYRVQAKGSNLEFALGYSHPVL
IDAPEGVTFAVETPTKFSISGIDKQKVGQIAANIRRLRKSDPYKGKGIRYEGEQIRRKKPHAQNVSAVRRRQRLRRHARL
RKKISGTAERPRLVVHRSSRHIHVQLVDDLTGTTLAAASSIEADVRGVDGDKKAHSVRVGQLIAERAKAAGVDERKDRIM
AEQPAGSAGPTNEGRDDRRDNRDNRGRRDGGGRGGRDRDGDKSNYLERVVTINRVSKVVKGGRRFSFTALVIVGDGNGMV
GVGYGKAKEVPAAIAKGVEEARKGFFRVPLIGGTVVHPVQGEAAAGVVLLRPASPGTGVIAGGAVRAVLECAGVRDVLAK
SLGSDNAINVVHATVAALKLLQRPEEVAARRGLPLEDVAPAGMLRARRESEALAASATRSKGKTAGRGTKGTKARKNVPA
TFEGGQMPIHMRLPKLKGFRNRFRTEYEVVNVGDLNRLFPEGGSVGLDELVAKGAVRKNTLVKVLGDGKLTVKVDITAHK
FSGSAREKITAAGAVGPGHRACRAYAVGGGDLDGADLLPVVVLHGVDVVGQVDASPGESARIQHRHRQPGRHRVQVQHRL
GARPAVHMRNQIAIDRRRQSDVQVEAEWGGDLVGEEPAQRAAGRIGVPDQLGFIPAQRERVIAVPAARRPGRGLRGQHRR
QLVLVAEVGQQQRRVQSRQPGLMRQQLAHRHIRFARLREVGPIVGDPGVVVNQSARGCERDRKRGNTFGRREHVDLGVAL
PRLLGDAVAVATPQVDHLDAVTVDRDRGADVAMRGEVRTEGIGDLAVTLVGVALDEIRWCCDLAAHHVHPRLDGIFFRNH
GHMRYHRQTDIACSHKTKKEEALRQRRMRLFDSAQLWNDFRGKTFHLLAVFGDGPTDRVEQNRLGARIDNRPQAPDDIVD
RARHRHVVDGRHLTVDAVQPVEHSLASPRRVVVDHQIDPLADREMCWVPALFGQFPAHAQDRLGELRRGRRARAEKCIAV
AHRAGQSLGRLTAEPDRRMRPLYGFGHNRQIVDLSEAAVEGDARLVRPCRLHQLQAFGEAADEGVGVDPECGELAPAAAR
RHPDIEPAVAEPVDRGCGVGQQFERRDQRRRADHLLDHPAALEAELLGPGQIFADTGRVEAGHIELMDRDRELHLINLRF
AHRVDTARHHGVPDGCVLELDLRAAPPEAGGLDPLAIITGGGRPLLLREAVAALHRAAEDSRVAGLIARVELPAAAAGPV
QELREAIAAFTAVKPSLAWAETYPGTLSYYLASAFGEVWMQPSGTVGLVGFATNALFLRDALDKAGIEAQFVARGEYKSA
ANLFTQDRYTDAHREADTRLLESLRGQVWQAIAESRNVGQDAVDGLADRAPLLRDVALESGLIDRVGFRDEAYARIAELA
NGENDSSIDADGDGAPPRLFLTRYARSTGPSIPGRGPKATIAIVTVAGPIVSGRGGSRVPFGSSNAGGDTIAAALREAAH
DDSVSAIVLRVDSPGGSVTASETIWREVAKARERGKPVVASMGAVAASGGYYVSMHADAIVANPGTITGSIGVVTGKLVA
RDLKDRLGVGSDAVRTNANADAWSINAPFTPEQQAQVEAEADLFYTDFVERVADGRNLSVDAVDAVARGRVWTGADALEH
GLVDELGGLRAAIRKAKVLAGLDEDDKVRVVSYPGSSVWDYVRPRSSSQPAAASLPDALGKLITQSVVGIIEDAERSLTG
ASVLWMGQSRY