PlantSME Plant secondary metabolism enzyme database
Terpenoid portable pathway

Terpenoid portable pathway

Category：Terpenoid pathway

Terpenoid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Terpenoid Reaction Route
MVA/MEP precursor branches to triterpenoid scaffolds, terpene scaffolds, and tailoring. Terpenoids draw IPP/DMAPP from MVA and MEP branches before prenyl extension and TPS branching; SQS/SQE/OSC form a triterpenoid/sterol precursor layer whose overlap with the steroid library is expected.
6 curated steps/modules
MVA And MEP Precursor Supply
01
Substrate
Acetyl-CoA
C23H38N7O17P3S
CH3-C(=O)-SCoA
Acetyl-CoA to IPP through the mevalonate branch
AACT337 HMGS2158 HMGR3794 MVK1409 PMK1501 MVD1588
Product
Isopentenyl diphosphate
C5H12O7P2
CH2=C(CH3)-CH2-CH2-OPP
The MVA branch supplies isoprene units for sesquiterpenoid, triterpenoid, and sterol-related metabolism.
02
Substrate
Pyruvate + glyceraldehyde-3-phosphate
C3 + C3 phosphates
CH3-CO-COO- + OHC-CHOH-CH2O-P
Pyruvate/G3P to IPP/DMAPP through the MEP branch
DXS4421 DXR1551 MCT/IspD1192 CMK/IspE1150 MDS/IspF1197 HDS/IspG1612 HDR/IspH1720
Product
IPP/DMAPP
C5H12O7P2
C5 isoprenyl diphosphates
The MEP branch mainly supplies precursors for monoterpenes, diterpenes, and plastidial terpenoids.
Prenyl Extension, Scaffold Formation, And Tailoring
03
Substrate
IPP/DMAPP
C5H12O7P2
C5 isoprenyl diphosphates
Isomerization and prenyl diphosphate extension
IDI1579 GPPS135 FPPS5839 GGPPS100
Product
GPP/FPP/GGPP
C10/C15/C20 diphosphates
prenyl-(C5)n-OPP
IDI and prenyltransferases generate GPP/FPP/GGPP substrates for TPS enzymes.
04
Substrate
FPP/squalene/2,3-oxidosqualene
C15/C30 precursors
linear isoprenoid precursor
Triterpenoid/sterol precursor scaffold formation
SQS/FDFT1 SQE OSC
Product
Triterpenoid/sterol precursor scaffolds
C30 scaffolds
cyclized triterpenoid scaffold
SQS, SQE, and OSC-family enzymes convert FPP-derived linear triterpenoid precursors into oxidosqualene cyclization products, forming a shared upstream layer for triterpenoid and sterol contexts.
05
Substrate
Prenyl diphosphates
C10/C15/C20
allylic polyisoprenyl-OPP
Terpene scaffold cyclization/rearrangement
TPS36208
Product
Terpene scaffolds
C10/C15/C20 hydrocarbons
cyclic/acyclic isoprenoid skeletons
TPS enzymes form terpene carbon scaffolds and act as central diversification points.
06
Substrate
Terpene scaffolds
C10-C20
isoprenoid hydrocarbon/oxygenated skeleton
Oxidation, glycosylation, and acylation tailoring
CYP7113248 CYP7646690 UGT123661 BAHD149019
Product
Tailored terpenoids
oxygenated/glycosylated/acylated terpenoids
terpene-OH / terpene-O-Glc / terpene-O-acyl
CYP/UGT/BAHD tailoring shapes polarity, storage form, and functional diversity of terpenoid products.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Algae (1439) Bryophytes (21449) Lycophytes/Ferns (1122) Gymnosperms (4211) Basal angiosperms (7276) Monocots (74873) Eudicots (289599)
Algae
Hits1439
Bryophytes
Hits21449
Lycophytes/Ferns
Hits1122
Gymnosperms
Hits4211
Basal angiosperms
Hits7276
Monocots
Hits74873
Eudicots
Hits289599
Species Distribution
Hordeum vulgare
Triticum turgidum
Aegilops tauschii
Triticum aestivum
Prunus domestica
Fragaria ananassa
Pogostemon cablin
Avena sativa
Diospyros kaki
Papaver setigerum
Lineage Summary
Algae
1439
Bryophytes
21449
Lycophytes/Ferns
1122
Gymnosperms
4211
Basal angiosperms
7276
Monocots
74873
Eudicots
289599
Module Gene List
GeneSpeciesProtein ID
Aalbaalba5_s000496350249110.1 abies_alba Aalbaalba5_s000496350249110.1
Aalbaalba5_s000496660249310.1 abies_alba Aalbaalba5_s000496660249310.1
Aalbaalba5_s000513590255320.1 abies_alba Aalbaalba5_s000513590255320.1
Aalbaalba5_s000513590255320.2 abies_alba Aalbaalba5_s000513590255320.2
Aalbaalba5_s000523610259280.1 abies_alba Aalbaalba5_s000523610259280.1
Aalbaalba5_s000530160261680.1 abies_alba Aalbaalba5_s000530160261680.1
Aalbaalba5_s000546670267650.1 abies_alba Aalbaalba5_s000546670267650.1
Aalbaalba5_s000546670267650.2 abies_alba Aalbaalba5_s000546670267650.2
Aalbaalba5_s000551020269210.1 abies_alba Aalbaalba5_s000551020269210.1
Aalbaalba5_s000551520269360.1 abies_alba Aalbaalba5_s000551520269360.1
Aalbaalba5_s000555790270850.1 abies_alba Aalbaalba5_s000555790270850.1
Aalbaalba5_s000566610274690.1 abies_alba Aalbaalba5_s000566610274690.1
Aalbaalba5_s000568430275240.1 abies_alba Aalbaalba5_s000568430275240.1
Aalbaalba5_s000577940278530.1 abies_alba Aalbaalba5_s000577940278530.1
Aalbaalba5_s000587590281740.1 abies_alba Aalbaalba5_s000587590281740.1
Aalbaalba5_s000587590281740.2 abies_alba Aalbaalba5_s000587590281740.2
Aalbaalba5_s000603310287330.1 abies_alba Aalbaalba5_s000603310287330.1
Aalbaalba5_s000619220292280.1 abies_alba Aalbaalba5_s000619220292280.1
Aalbaalba5_s000632190296930.1 abies_alba Aalbaalba5_s000632190296930.1
Aalbaalba5_s000673940310290.1 abies_alba Aalbaalba5_s000673940310290.1
Aalbaalba5_s000677620311420.1 abies_alba Aalbaalba5_s000677620311420.1
Aalbaalba5_s000689950315250.1 abies_alba Aalbaalba5_s000689950315250.1
Aalbaalba5_s000705990320400.1 abies_alba Aalbaalba5_s000705990320400.1
Aalbaalba5_s000706280320520.1 abies_alba Aalbaalba5_s000706280320520.1
Aalbaalba5_s000709150321250.1 abies_alba Aalbaalba5_s000709150321250.1
Aalbaalba5_s000709150321260.1 abies_alba Aalbaalba5_s000709150321260.1
Aalbaalba5_s000732680328310.1 abies_alba Aalbaalba5_s000732680328310.1
Aalbaalba5_s000746540332460.1 abies_alba Aalbaalba5_s000746540332460.1
Aalbaalba5_s000753980334680.1 abies_alba Aalbaalba5_s000753980334680.1
Aalbaalba5_s000753980334680.2 abies_alba Aalbaalba5_s000753980334680.2