PlantSME Plant secondary metabolism enzyme database
Flavonoid portable pathway

Flavonoid portable pathway

Category：Flavonoid pathway

Flavonoid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Flavonoid Reaction Route
Phenylpropanoid entry, flavonoid scaffold, and anthocyanin branches. The flavonoid pathway is branched; this view arranges the main scaffold and common branches into a readable representative route without forcing all branches into one linear pathway.
9 curated steps/modules
From Phenylpropanoid Entry To Flavonoid Scaffold
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination to the cinnamate entry point
PAL3389
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL commits L-phenylalanine to the phenylpropanoid entry route that supplies the flavonoid acyl donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Para-hydroxylation of cinnamate
C4H1799
Product
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A hydroxylates cinnamate to p-coumarate, a required phenylpropanoid step toward the flavonoid donor.
03
Substrate
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the flavonoid acyl donor
4CL7972
Product
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL activates p-coumarate to p-coumaroyl-CoA for CHS-mediated flavonoid scaffold formation.
04
Substrate
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
Malonyl-CoA
C24H38N7O19P3S
HOOC-CH2-C(=O)-SCoA
Condensation of the C6-C3-C6 scaffold
CHS3396
Product
Naringenin chalcone
C15H12O5
HO-Ar-CO-CH=CH-Ar-(OH)2
CHS condenses one p-coumaroyl-CoA with three malonyl-CoA units to form a chalcone scaffold.
05
Substrate
Naringenin chalcone
C15H12O5
HO-Ar-CO-CH=CH-Ar-(OH)2
Chalcone cyclization
CHI2403
Product
Naringenin
C15H12O5
flavanone C6-C3-C6 ring
CHI converts the open-chain chalcone into the flavanone core.
06
Substrate
Naringenin
C15H12O5
flavanone C6-C3-C6 ring
C-ring 3-hydroxylation to dihydroflavonols
F3H3152
Product
Dihydrokaempferol
C15H12O6
dihydroflavonol C-ring
F3H is a 2-oxoglutarate-dependent dioxygenase that converts flavanones into the dihydroflavonol pool.
07
Substrate
Flavanones/dihydroflavonols
C15H12O5-6
C6-C3-C6 oxygen heterocycle
B-ring hydroxylation shapes flavonoid hydroxylation patterns
F3'H/CYP75B2154 F3'5'H/CYP75A309
Product
B-ring hydroxylated flavonoid intermediates
C15H12O6-7
3'/3'5'-hydroxylated flavonoids
CYP75B/F3'H and CYP75A/F3'5'H alter B-ring hydroxylation and generate precursors for quercetin- and myricetin-type branches.
Flavone, Anthocyanin, And Proanthocyanidin Branches
08
Substrate
Flavanones/dihydroflavonols
C15 flavonoids
C6-C3-C6 oxygen heterocycle
Flavone, isoflavonoid, and flavonol branches
FNS91 IFS75 IFR1953 FLS11
Product
Flavones/isoflavones/flavonols
C15H10O5-7
oxidized C6-C3-C6 flavonoids
Branch enzymes route shared intermediates into distinct flavonoid subclasses.
09
Substrate
Dihydroflavonols
C15H12O6-7
dihydroflavonol C-ring
Anthocyanin and proanthocyanidin direction
DFR1276 ANS/LDOX1560 UFGT21465 ANR425
Product
Anthocyanin glycosides/proanthocyanidins
C15 glycosides/polymers
flavylium-glycoside / flavan-3-ol polymer
DFR/ANS/UFGT/ANR route the dihydroflavonol pool toward pigments and condensed tannins.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Monocots (51430)
Current lineage filter: Monocots. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits51430
Eudicots
Hits0
Species Distribution
Aegilops tauschii
Avena sativa
Triticum turgidum
Eragrostis nindensis
Cenchrus fungigraminus
Triticum aestivum
Hordeum vulgare
Digitaria exilis
Bothriochloa decipiens
Rhynchospora pubera
Lineage Summary
Monocots
51430
Module Gene List
Reset
GeneSpeciesProtein ID
acorus_gramineus_AGRA_17326 acorus_gramineus acorus_gramineus_AGRA_17326
acorus_gramineus_AGRA_17427 acorus_gramineus acorus_gramineus_AGRA_17427
acorus_gramineus_AGRA_17439 acorus_gramineus acorus_gramineus_AGRA_17439
acorus_gramineus_AGRA_17454 acorus_gramineus acorus_gramineus_AGRA_17454
acorus_gramineus_AGRA_17483 acorus_gramineus acorus_gramineus_AGRA_17483
acorus_gramineus_AGRA_17484 acorus_gramineus acorus_gramineus_AGRA_17484
acorus_gramineus_AGRA_17670 acorus_gramineus acorus_gramineus_AGRA_17670
acorus_gramineus_AGRA_18074 acorus_gramineus acorus_gramineus_AGRA_18074
acorus_gramineus_AGRA_18075 acorus_gramineus acorus_gramineus_AGRA_18075
acorus_gramineus_AGRA_18690 acorus_gramineus acorus_gramineus_AGRA_18690
acorus_gramineus_AGRA_18911 acorus_gramineus acorus_gramineus_AGRA_18911
acorus_gramineus_AGRA_18935 acorus_gramineus acorus_gramineus_AGRA_18935
acorus_gramineus_AGRA_18938 acorus_gramineus acorus_gramineus_AGRA_18938
acorus_gramineus_AGRA_18939 acorus_gramineus acorus_gramineus_AGRA_18939
acorus_gramineus_AGRA_18940 acorus_gramineus acorus_gramineus_AGRA_18940
acorus_gramineus_AGRA_19310 acorus_gramineus acorus_gramineus_AGRA_19310
acorus_gramineus_AGRA_19325 acorus_gramineus acorus_gramineus_AGRA_19325
acorus_gramineus_AGRA_19373 acorus_gramineus acorus_gramineus_AGRA_19373
acorus_gramineus_AGRA_19439 acorus_gramineus acorus_gramineus_AGRA_19439
acorus_gramineus_AGRA_19516 acorus_gramineus acorus_gramineus_AGRA_19516
acorus_gramineus_AGRA_19953 acorus_gramineus acorus_gramineus_AGRA_19953
acorus_gramineus_AGRA_20376 acorus_gramineus acorus_gramineus_AGRA_20376
acorus_gramineus_AGRA_20628 acorus_gramineus acorus_gramineus_AGRA_20628
acorus_gramineus_AGRA_20629 acorus_gramineus acorus_gramineus_AGRA_20629
acorus_gramineus_AGRA_20828 acorus_gramineus acorus_gramineus_AGRA_20828
acorus_gramineus_AGRA_21012 acorus_gramineus acorus_gramineus_AGRA_21012
acorus_gramineus_AGRA_21013 acorus_gramineus acorus_gramineus_AGRA_21013
acorus_gramineus_AGRA_21014 acorus_gramineus acorus_gramineus_AGRA_21014
acorus_gramineus_AGRA_21015 acorus_gramineus acorus_gramineus_AGRA_21015
acorus_gramineus_AGRA_21016 acorus_gramineus acorus_gramineus_AGRA_21016