PlantSME Plant secondary metabolism enzyme database
Phenylpropanoid portable pathway

Phenylpropanoid portable pathway

Category：Phenylpropanoid pathway

Phenylpropanoid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Phenylpropanoid Reaction Route
Entry backbone to monolignol/lignin branches. Substrates, products, and condensed structural formulae show representative conversions; resolved reactions are shown as single enzymes, whereas multi-enzyme branches are shown as curated modules. Member counts come from public annotations.
6 curated steps/modules
Entry Backbone And Lignin Direction
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination to form the phenylpropene acid scaffold
PAL3220
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL commits the amino-acid substrate to phenylpropanoid metabolism.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Para-hydroxylation of the aromatic ring
C4H1888
Product
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A introduces the 4-hydroxyl group for downstream CoA activation.
03
Substrate
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation and activation
4CL7953
Product
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL converts the free acid into a thioester used by condensation, acyltransfer, and reduction reactions.
04
Substrate
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Hydroxylation, acyl transfer, and methylation
HCT7570 C3'H/CYP98A4224 CSE7936 CCoAOMT1158
Product
Feruloyl-CoA-type intermediates
C31H40N7O19P3S
3-MeO-4-HO-C6H3-CH=CH-C(=O)-SCoA
This segment remodels the p-coumaroyl scaffold into caffeoyl/feruloyl-type intermediates.
05
Substrate
Hydroxycinnamoyl-CoA
C30-31 CoA thioesters
Ar-CH=CH-C(=O)-SCoA
Reduction and S/G monolignol formation
CCR4523 CAD5707 F5H/CYP84A709 COMT4327
Product
Coniferyl/sinapyl alcohol
C10H12O3 / C11H14O4
Ar-CH=CH-CH2OH
CCR/CAD and related steps route CoA thioesters toward monolignol monomers.
06
Substrate
Monolignols
C9-C11 phenylpropanoids
Ar-CH=CH-CH2OH
Oxidative coupling and polymerization
LAC9545 POD33718
Product
Lignin polymer
(C9 unit)n
[Ar-C3]n ether/C-C polymer
LAC/POD oxidatively couple monolignols into lignin polymers.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Monocots (92478)
Current lineage filter: Monocots. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits92478
Eudicots
Hits0
Species Distribution
Aegilops tauschii
Avena sativa
Triticum turgidum
Cenchrus fungigraminus
Eragrostis nindensis
Hordeum vulgare
Triticum aestivum
Bothriochloa decipiens
Brachypodium hybridum
Digitaria exilis
Lineage Summary
Monocots
92478
Module Gene List
Reset
GeneSpeciesProtein ID
acorus_gramineus_AGRA_00920 acorus_gramineus acorus_gramineus_AGRA_00920
acorus_gramineus_AGRA_01122 acorus_gramineus acorus_gramineus_AGRA_01122
acorus_gramineus_AGRA_01162 acorus_gramineus acorus_gramineus_AGRA_01162
acorus_gramineus_AGRA_01165 acorus_gramineus acorus_gramineus_AGRA_01165
acorus_gramineus_AGRA_01352 acorus_gramineus acorus_gramineus_AGRA_01352
acorus_gramineus_AGRA_01361 acorus_gramineus acorus_gramineus_AGRA_01361
acorus_gramineus_AGRA_01398 acorus_gramineus acorus_gramineus_AGRA_01398
acorus_gramineus_AGRA_01420 acorus_gramineus acorus_gramineus_AGRA_01420
acorus_gramineus_AGRA_01583 acorus_gramineus acorus_gramineus_AGRA_01583
acorus_gramineus_AGRA_01585 acorus_gramineus acorus_gramineus_AGRA_01585
acorus_gramineus_AGRA_01731 acorus_gramineus acorus_gramineus_AGRA_01731
acorus_gramineus_AGRA_01782 acorus_gramineus acorus_gramineus_AGRA_01782
acorus_gramineus_AGRA_02037 acorus_gramineus acorus_gramineus_AGRA_02037
acorus_gramineus_AGRA_02093 acorus_gramineus acorus_gramineus_AGRA_02093
acorus_gramineus_AGRA_02522 acorus_gramineus acorus_gramineus_AGRA_02522
acorus_gramineus_AGRA_02525 acorus_gramineus acorus_gramineus_AGRA_02525
acorus_gramineus_AGRA_02649 acorus_gramineus acorus_gramineus_AGRA_02649
acorus_gramineus_AGRA_02685 acorus_gramineus acorus_gramineus_AGRA_02685
acorus_gramineus_AGRA_02686 acorus_gramineus acorus_gramineus_AGRA_02686
acorus_gramineus_AGRA_02724 acorus_gramineus acorus_gramineus_AGRA_02724
acorus_gramineus_AGRA_02735 acorus_gramineus acorus_gramineus_AGRA_02735
acorus_gramineus_AGRA_02765 acorus_gramineus acorus_gramineus_AGRA_02765
acorus_gramineus_AGRA_02791 acorus_gramineus acorus_gramineus_AGRA_02791
acorus_gramineus_AGRA_02792 acorus_gramineus acorus_gramineus_AGRA_02792
acorus_gramineus_AGRA_02793 acorus_gramineus acorus_gramineus_AGRA_02793
acorus_gramineus_AGRA_02802 acorus_gramineus acorus_gramineus_AGRA_02802
acorus_gramineus_AGRA_02803 acorus_gramineus acorus_gramineus_AGRA_02803
acorus_gramineus_AGRA_02807 acorus_gramineus acorus_gramineus_AGRA_02807
acorus_gramineus_AGRA_02810 acorus_gramineus acorus_gramineus_AGRA_02810
acorus_gramineus_AGRA_02861 acorus_gramineus acorus_gramineus_AGRA_02861