PlantSME Plant secondary metabolism enzyme database
Phenylpropanoid portable pathway

Phenylpropanoid portable pathway

Category：Phenylpropanoid pathway

Phenylpropanoid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Phenylpropanoid Reaction Route
Entry backbone to monolignol/lignin branches. Substrates, products, and condensed structural formulae show representative conversions; resolved reactions are shown as single enzymes, whereas multi-enzyme branches are shown as curated modules. Member counts come from public annotations.
6 curated steps/modules
Entry Backbone And Lignin Direction
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination to form the phenylpropene acid scaffold
PAL3220
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL commits the amino-acid substrate to phenylpropanoid metabolism.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Para-hydroxylation of the aromatic ring
C4H1888
Product
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A introduces the 4-hydroxyl group for downstream CoA activation.
03
Substrate
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation and activation
4CL7953
Product
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL converts the free acid into a thioester used by condensation, acyltransfer, and reduction reactions.
04
Substrate
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Hydroxylation, acyl transfer, and methylation
HCT7570 C3'H/CYP98A4224 CSE7936 CCoAOMT1158
Product
Feruloyl-CoA-type intermediates
C31H40N7O19P3S
3-MeO-4-HO-C6H3-CH=CH-C(=O)-SCoA
This segment remodels the p-coumaroyl scaffold into caffeoyl/feruloyl-type intermediates.
05
Substrate
Hydroxycinnamoyl-CoA
C30-31 CoA thioesters
Ar-CH=CH-C(=O)-SCoA
Reduction and S/G monolignol formation
CCR4523 CAD5707 F5H/CYP84A709 COMT4327
Product
Coniferyl/sinapyl alcohol
C10H12O3 / C11H14O4
Ar-CH=CH-CH2OH
CCR/CAD and related steps route CoA thioesters toward monolignol monomers.
06
Substrate
Monolignols
C9-C11 phenylpropanoids
Ar-CH=CH-CH2OH
Oxidative coupling and polymerization
LAC9545 POD33718
Product
Lignin polymer
(C9 unit)n
[Ar-C3]n ether/C-C polymer
LAC/POD oxidatively couple monolignols into lignin polymers.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Monocots (92478)
Current lineage filter: Monocots. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits92478
Eudicots
Hits0
Species Distribution
Aegilops tauschii
Avena sativa
Triticum turgidum
Cenchrus fungigraminus
Eragrostis nindensis
Hordeum vulgare
Triticum aestivum
Bothriochloa decipiens
Brachypodium hybridum
Digitaria exilis
Lineage Summary
Monocots
92478
Module Gene List
Reset
GeneSpeciesProtein ID
acorus_gramineus_AGRA_18404 acorus_gramineus acorus_gramineus_AGRA_18404
acorus_gramineus_AGRA_18437 acorus_gramineus acorus_gramineus_AGRA_18437
acorus_gramineus_AGRA_18531 acorus_gramineus acorus_gramineus_AGRA_18531
acorus_gramineus_AGRA_18935 acorus_gramineus acorus_gramineus_AGRA_18935
acorus_gramineus_AGRA_18981 acorus_gramineus acorus_gramineus_AGRA_18981
acorus_gramineus_AGRA_18992 acorus_gramineus acorus_gramineus_AGRA_18992
acorus_gramineus_AGRA_19058 acorus_gramineus acorus_gramineus_AGRA_19058
acorus_gramineus_AGRA_19091 acorus_gramineus acorus_gramineus_AGRA_19091
acorus_gramineus_AGRA_19238 acorus_gramineus acorus_gramineus_AGRA_19238
acorus_gramineus_AGRA_19297 acorus_gramineus acorus_gramineus_AGRA_19297
acorus_gramineus_AGRA_19310 acorus_gramineus acorus_gramineus_AGRA_19310
acorus_gramineus_AGRA_19325 acorus_gramineus acorus_gramineus_AGRA_19325
acorus_gramineus_AGRA_19386 acorus_gramineus acorus_gramineus_AGRA_19386
acorus_gramineus_AGRA_19429 acorus_gramineus acorus_gramineus_AGRA_19429
acorus_gramineus_AGRA_19439 acorus_gramineus acorus_gramineus_AGRA_19439
acorus_gramineus_AGRA_19446 acorus_gramineus acorus_gramineus_AGRA_19446
acorus_gramineus_AGRA_19516 acorus_gramineus acorus_gramineus_AGRA_19516
acorus_gramineus_AGRA_19554 acorus_gramineus acorus_gramineus_AGRA_19554
acorus_gramineus_AGRA_19578 acorus_gramineus acorus_gramineus_AGRA_19578
acorus_gramineus_AGRA_19749 acorus_gramineus acorus_gramineus_AGRA_19749
acorus_gramineus_AGRA_19750 acorus_gramineus acorus_gramineus_AGRA_19750
acorus_gramineus_AGRA_19751 acorus_gramineus acorus_gramineus_AGRA_19751
acorus_gramineus_AGRA_19764 acorus_gramineus acorus_gramineus_AGRA_19764
acorus_gramineus_AGRA_19769 acorus_gramineus acorus_gramineus_AGRA_19769
acorus_gramineus_AGRA_19890 acorus_gramineus acorus_gramineus_AGRA_19890
acorus_gramineus_AGRA_19912 acorus_gramineus acorus_gramineus_AGRA_19912
acorus_gramineus_AGRA_19925 acorus_gramineus acorus_gramineus_AGRA_19925
acorus_gramineus_AGRA_19949 acorus_gramineus acorus_gramineus_AGRA_19949
acorus_gramineus_AGRA_19953 acorus_gramineus acorus_gramineus_AGRA_19953
acorus_gramineus_AGRA_20010 acorus_gramineus acorus_gramineus_AGRA_20010