PlantSME Plant secondary metabolism enzyme database
Phenylpropanoid portable pathway

Phenylpropanoid portable pathway

Category：Phenylpropanoid pathway

Phenylpropanoid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Phenylpropanoid Reaction Route
Entry backbone to monolignol/lignin branches. Substrates, products, and condensed structural formulae show representative conversions; resolved reactions are shown as single enzymes, whereas multi-enzyme branches are shown as curated modules. Member counts come from public annotations.
6 curated steps/modules
Entry Backbone And Lignin Direction
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination to form the phenylpropene acid scaffold
PAL196
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL commits the amino-acid substrate to phenylpropanoid metabolism.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Para-hydroxylation of the aromatic ring
C4H193
Product
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A introduces the 4-hydroxyl group for downstream CoA activation.
03
Substrate
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation and activation
4CL771
Product
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL converts the free acid into a thioester used by condensation, acyltransfer, and reduction reactions.
04
Substrate
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Hydroxylation, acyl transfer, and methylation
HCT676 C3'H/CYP98A400 CSE681 CCoAOMT130
Product
Feruloyl-CoA-type intermediates
C31H40N7O19P3S
3-MeO-4-HO-C6H3-CH=CH-C(=O)-SCoA
This segment remodels the p-coumaroyl scaffold into caffeoyl/feruloyl-type intermediates.
05
Substrate
Hydroxycinnamoyl-CoA
C30-31 CoA thioesters
Ar-CH=CH-C(=O)-SCoA
Reduction and S/G monolignol formation
CCR505 CAD711 F5H/CYP84A83 COMT604
Product
Coniferyl/sinapyl alcohol
C10H12O3 / C11H14O4
Ar-CH=CH-CH2OH
CCR/CAD and related steps route CoA thioesters toward monolignol monomers.
06
Substrate
Monolignols
C9-C11 phenylpropanoids
Ar-CH=CH-CH2OH
Oxidative coupling and polymerization
LAC945 POD2554
Product
Lignin polymer
(C9 unit)n
[Ar-C3]n ether/C-C polymer
LAC/POD oxidatively couple monolignols into lignin polymers.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Basal angiosperms (8449)
Current lineage filter: Basal angiosperms. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits8449
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Brasenia schreberi
Annona cherimola
Cinnamomum kanehirae
Chloranthus sessilifolius
Amborella trichopoda
Aristolochia contorta
Cinnamomum camphora
Piper nigrum
Liriodendron chinense
Piper longum
Lineage Summary
Basal angiosperms
8449
Module Gene List
Reset
GeneSpeciesProtein ID
annona_cherimola_Anche102Scf0030g0000430.1 annona_cherimola annona_cherimola_Anche102Scf0030g0000430.1
annona_cherimola_Anche102Scf0035g0000200.1 annona_cherimola annona_cherimola_Anche102Scf0035g0000200.1
annona_cherimola_Anche102Scf0037g0000210.1 annona_cherimola annona_cherimola_Anche102Scf0037g0000210.1
annona_cherimola_Anche102Scf0042g0000190.1 annona_cherimola annona_cherimola_Anche102Scf0042g0000190.1
annona_cherimola_Anche102Scf0059g0000080.1 annona_cherimola annona_cherimola_Anche102Scf0059g0000080.1
annona_cherimola_Anche102Scf0066g0000140.1 annona_cherimola annona_cherimola_Anche102Scf0066g0000140.1
annona_cherimola_Anche102Scf0080g0000070.1 annona_cherimola annona_cherimola_Anche102Scf0080g0000070.1
annona_cherimola_Anche102Scf0086g0000070.1 annona_cherimola annona_cherimola_Anche102Scf0086g0000070.1
annona_cherimola_Anche102Scf0088g0000030.1 annona_cherimola annona_cherimola_Anche102Scf0088g0000030.1
annona_cherimola_Anche102Scf0088g0000040.1 annona_cherimola annona_cherimola_Anche102Scf0088g0000040.1
annona_cherimola_Anche102Scf0110g0000080.1 annona_cherimola annona_cherimola_Anche102Scf0110g0000080.1
annona_cherimola_Anche102Scf0111g0000060.1 annona_cherimola annona_cherimola_Anche102Scf0111g0000060.1
annona_cherimola_Anche102Scf0157g0000010.1 annona_cherimola annona_cherimola_Anche102Scf0157g0000010.1
annona_cherimola_Anche102Scf0158g0000010.1 annona_cherimola annona_cherimola_Anche102Scf0158g0000010.1
annona_cherimola_Anche102Scf0184g0000020.1 annona_cherimola annona_cherimola_Anche102Scf0184g0000020.1
annona_cherimola_Anche102Scf0233g0000030.1 annona_cherimola annona_cherimola_Anche102Scf0233g0000030.1
annona_cherimola_Anche102Scf0260g0000040.1 annona_cherimola annona_cherimola_Anche102Scf0260g0000040.1
annona_cherimola_Anche102Scf0295g0000050.1 annona_cherimola annona_cherimola_Anche102Scf0295g0000050.1
annona_cherimola_Anche102Scf0398g0000010.1 annona_cherimola annona_cherimola_Anche102Scf0398g0000010.1
annona_cherimola_Anche102Scf0479g0000090.1 annona_cherimola annona_cherimola_Anche102Scf0479g0000090.1
annona_cherimola_Anche102Scf0762g0000020.1 annona_cherimola annona_cherimola_Anche102Scf0762g0000020.1
annona_cherimola_Anche102Scf0774g0000030.1 annona_cherimola annona_cherimola_Anche102Scf0774g0000030.1
annona_cherimola_Anche102Scf0829g0000010.1 annona_cherimola annona_cherimola_Anche102Scf0829g0000010.1
annona_cherimola_Anche102Scf0859g0000010.1 annona_cherimola annona_cherimola_Anche102Scf0859g0000010.1
annona_cherimola_Anche102Scf0935g0000030.1 annona_cherimola annona_cherimola_Anche102Scf0935g0000030.1
annona_cherimola_Anche102Scf0954g0000010.1 annona_cherimola annona_cherimola_Anche102Scf0954g0000010.1
EVM0000026.mRNA1 aristolochia_contorta EVM0000026.mRNA1
EVM0000088.mRNA1 aristolochia_contorta EVM0000088.mRNA1
EVM0000123.mRNA1 aristolochia_contorta EVM0000123.mRNA1
EVM0000250.mRNA1 aristolochia_contorta EVM0000250.mRNA1