PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL200
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H2695
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL772
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT558
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR365
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS1035
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR304
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Basal angiosperms (5929)
Current lineage filter: Basal angiosperms. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits5929
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Annona cherimola
Brasenia schreberi
Cinnamomum kanehirae
Chloranthus sessilifolius
Aristolochia contorta
Cinnamomum camphora
Amborella trichopoda
Piper nigrum
Liriodendron chinense
Saururus chinensis
Lineage Summary
Basal angiosperms
5929
Module Gene List
Reset
GeneSpeciesProtein ID
NcolGWHAAYW000000070125510.1 nymphaea_colorata NcolGWHAAYW000000070125510.1
NcolGWHAAYW000000070125520.1 nymphaea_colorata NcolGWHAAYW000000070125520.1
NcolGWHAAYW000000070125530.1 nymphaea_colorata NcolGWHAAYW000000070125530.1
NcolGWHAAYW000000070125580.1 nymphaea_colorata NcolGWHAAYW000000070125580.1
NcolGWHAAYW000000070125600.1 nymphaea_colorata NcolGWHAAYW000000070125600.1
NcolGWHAAYW000000070125990.1 nymphaea_colorata NcolGWHAAYW000000070125990.1
NcolGWHAAYW000000070131620.1 nymphaea_colorata NcolGWHAAYW000000070131620.1
NcolGWHAAYW000000080138520.1 nymphaea_colorata NcolGWHAAYW000000080138520.1
NcolGWHAAYW000000080143650.1 nymphaea_colorata NcolGWHAAYW000000080143650.1
NcolGWHAAYW000000080143660.1 nymphaea_colorata NcolGWHAAYW000000080143660.1
NcolGWHAAYW000000080143670.1 nymphaea_colorata NcolGWHAAYW000000080143670.1
NcolGWHAAYW000000080145370.1 nymphaea_colorata NcolGWHAAYW000000080145370.1
NcolGWHAAYW000000080145370.2 nymphaea_colorata NcolGWHAAYW000000080145370.2
NcolGWHAAYW000000080145370.3 nymphaea_colorata NcolGWHAAYW000000080145370.3
NcolGWHAAYW000000080146960.1 nymphaea_colorata NcolGWHAAYW000000080146960.1
NcolGWHAAYW000000080146970.1 nymphaea_colorata NcolGWHAAYW000000080146970.1
NcolGWHAAYW000000090153150.1 nymphaea_colorata NcolGWHAAYW000000090153150.1
NcolGWHAAYW000000090154290.1 nymphaea_colorata NcolGWHAAYW000000090154290.1
NcolGWHAAYW000000090155000.1 nymphaea_colorata NcolGWHAAYW000000090155000.1
NcolGWHAAYW000000090160920.1 nymphaea_colorata NcolGWHAAYW000000090160920.1
NcolGWHAAYW000000090162910.1 nymphaea_colorata NcolGWHAAYW000000090162910.1
NcolGWHAAYW000000090163610.1 nymphaea_colorata NcolGWHAAYW000000090163610.1
NcolGWHAAYW000000090163610.2 nymphaea_colorata NcolGWHAAYW000000090163610.2
NcolGWHAAYW000000090163610.3 nymphaea_colorata NcolGWHAAYW000000090163610.3
NcolGWHAAYW000000090163620.1 nymphaea_colorata NcolGWHAAYW000000090163620.1
NcolGWHAAYW000000090163630.1 nymphaea_colorata NcolGWHAAYW000000090163630.1
NcolGWHAAYW000000090163630.2 nymphaea_colorata NcolGWHAAYW000000090163630.2
NcolGWHAAYW000000090163630.3 nymphaea_colorata NcolGWHAAYW000000090163630.3
NcolGWHAAYW000000090163630.4 nymphaea_colorata NcolGWHAAYW000000090163630.4
NcolGWHAAYW000000090163630.5 nymphaea_colorata NcolGWHAAYW000000090163630.5