PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL146
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H1115
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL584
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT251
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR200
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS458
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR135
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Gymnosperms (2889)
Current lineage filter: Gymnosperms. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits2889
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Ginkgo biloba
Abies alba
Gnetum montanum
Pinus taeda
Taxus chinensis
Welwitschia mirabilis
Lineage Summary
Gymnosperms
2889
Module Gene List
Reset
GeneSpeciesProtein ID
Aalbaalba5_s002425880657270.1 abies_alba Aalbaalba5_s002425880657270.1
Aalbaalba5_s002462010661780.1 abies_alba Aalbaalba5_s002462010661780.1
Aalbaalba5_s002493540664930.1 abies_alba Aalbaalba5_s002493540664930.1
Aalbaalba5_s002505380666270.1 abies_alba Aalbaalba5_s002505380666270.1
Aalbaalba5_s002515370667360.1 abies_alba Aalbaalba5_s002515370667360.1
Aalbaalba5_s002553570672000.1 abies_alba Aalbaalba5_s002553570672000.1
Aalbaalba5_s002824410699500.1 abies_alba Aalbaalba5_s002824410699500.1
Aalbaalba5_s002826550699770.1 abies_alba Aalbaalba5_s002826550699770.1
Aalbaalba5_s002954550711360.1 abies_alba Aalbaalba5_s002954550711360.1
Aalbaalba5_s003113330724620.1 abies_alba Aalbaalba5_s003113330724620.1
Aalbaalba5_s003188490730760.1 abies_alba Aalbaalba5_s003188490730760.1
Aalbaalba5_s003194790731170.1 abies_alba Aalbaalba5_s003194790731170.1
Aalbaalba5_s003305710739710.1 abies_alba Aalbaalba5_s003305710739710.1
Aalbaalba5_s003314240740370.1 abies_alba Aalbaalba5_s003314240740370.1
Aalbaalba5_s003385330745300.1 abies_alba Aalbaalba5_s003385330745300.1
Aalbaalba5_s003406890746880.1 abies_alba Aalbaalba5_s003406890746880.1
Aalbaalba5_s003497020752740.1 abies_alba Aalbaalba5_s003497020752740.1
Aalbaalba5_s003718010766610.1 abies_alba Aalbaalba5_s003718010766610.1
Aalbaalba5_s003814060772560.1 abies_alba Aalbaalba5_s003814060772560.1
Aalbaalba5_s003958990780150.1 abies_alba Aalbaalba5_s003958990780150.1
Aalbaalba5_s004032460784540.1 abies_alba Aalbaalba5_s004032460784540.1
Aalbaalba5_s004270170797470.1 abies_alba Aalbaalba5_s004270170797470.1
Aalbaalba5_s004301480799140.1 abies_alba Aalbaalba5_s004301480799140.1
Aalbaalba5_s004842190822600.1 abies_alba Aalbaalba5_s004842190822600.1
Aalbaalba5_s004882680824470.1 abies_alba Aalbaalba5_s004882680824470.1
Aalbaalba5_s004884800824610.1 abies_alba Aalbaalba5_s004884800824610.1
Aalbaalba5_s004922000825930.1 abies_alba Aalbaalba5_s004922000825930.1
Aalbaalba5_s004990370829070.1 abies_alba Aalbaalba5_s004990370829070.1
Aalbaalba5_s005106700833560.1 abies_alba Aalbaalba5_s005106700833560.1
Aalbaalba5_s005160220835410.1 abies_alba Aalbaalba5_s005160220835410.1