PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL3395
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H24785
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL7977
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT6058
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR3646
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS9170
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR2900
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Monocots (57931)
Current lineage filter: Monocots. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits57931
Eudicots
Hits0
Species Distribution
Aegilops tauschii
Avena sativa
Eragrostis nindensis
Cenchrus fungigraminus
Bothriochloa decipiens
Digitaria exilis
Echinochloa oryzicola
Eleusine coracana
Brachypodium hybridum
Daemonorops jenkinsiana
Lineage Summary
Monocots
57931
Module Gene List
Reset
GeneSpeciesProtein ID
acorus_gramineus_AGRA_08627 acorus_gramineus acorus_gramineus_AGRA_08627
acorus_gramineus_AGRA_08628 acorus_gramineus acorus_gramineus_AGRA_08628
acorus_gramineus_AGRA_08629 acorus_gramineus acorus_gramineus_AGRA_08629
acorus_gramineus_AGRA_08631 acorus_gramineus acorus_gramineus_AGRA_08631
acorus_gramineus_AGRA_08633 acorus_gramineus acorus_gramineus_AGRA_08633
acorus_gramineus_AGRA_08669 acorus_gramineus acorus_gramineus_AGRA_08669
acorus_gramineus_AGRA_08670 acorus_gramineus acorus_gramineus_AGRA_08670
acorus_gramineus_AGRA_08671 acorus_gramineus acorus_gramineus_AGRA_08671
acorus_gramineus_AGRA_08672 acorus_gramineus acorus_gramineus_AGRA_08672
acorus_gramineus_AGRA_08673 acorus_gramineus acorus_gramineus_AGRA_08673
acorus_gramineus_AGRA_08674 acorus_gramineus acorus_gramineus_AGRA_08674
acorus_gramineus_AGRA_08675 acorus_gramineus acorus_gramineus_AGRA_08675
acorus_gramineus_AGRA_08718 acorus_gramineus acorus_gramineus_AGRA_08718
acorus_gramineus_AGRA_09040 acorus_gramineus acorus_gramineus_AGRA_09040
acorus_gramineus_AGRA_09249 acorus_gramineus acorus_gramineus_AGRA_09249
acorus_gramineus_AGRA_09307 acorus_gramineus acorus_gramineus_AGRA_09307
acorus_gramineus_AGRA_09343 acorus_gramineus acorus_gramineus_AGRA_09343
acorus_gramineus_AGRA_09405 acorus_gramineus acorus_gramineus_AGRA_09405
acorus_gramineus_AGRA_09503 acorus_gramineus acorus_gramineus_AGRA_09503
acorus_gramineus_AGRA_09529 acorus_gramineus acorus_gramineus_AGRA_09529
acorus_gramineus_AGRA_09562 acorus_gramineus acorus_gramineus_AGRA_09562
acorus_gramineus_AGRA_09590 acorus_gramineus acorus_gramineus_AGRA_09590
acorus_gramineus_AGRA_10020 acorus_gramineus acorus_gramineus_AGRA_10020
acorus_gramineus_AGRA_10335 acorus_gramineus acorus_gramineus_AGRA_10335
acorus_gramineus_AGRA_10683 acorus_gramineus acorus_gramineus_AGRA_10683
acorus_gramineus_AGRA_10684 acorus_gramineus acorus_gramineus_AGRA_10684
acorus_gramineus_AGRA_10730 acorus_gramineus acorus_gramineus_AGRA_10730
acorus_gramineus_AGRA_10731 acorus_gramineus acorus_gramineus_AGRA_10731
acorus_gramineus_AGRA_10732 acorus_gramineus acorus_gramineus_AGRA_10732
acorus_gramineus_AGRA_10735 acorus_gramineus acorus_gramineus_AGRA_10735