PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL3395
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H24785
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL7977
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT6058
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR3646
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS9170
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR2900
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Monocots (57931)
Current lineage filter: Monocots. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits57931
Eudicots
Hits0
Species Distribution
Aegilops tauschii
Avena sativa
Eragrostis nindensis
Cenchrus fungigraminus
Bothriochloa decipiens
Digitaria exilis
Echinochloa oryzicola
Eleusine coracana
Brachypodium hybridum
Daemonorops jenkinsiana
Lineage Summary
Monocots
57931
Module Gene List
Reset
GeneSpeciesProtein ID
acorus_gramineus_AGRA_17805 acorus_gramineus acorus_gramineus_AGRA_17805
acorus_gramineus_AGRA_17806 acorus_gramineus acorus_gramineus_AGRA_17806
acorus_gramineus_AGRA_17948 acorus_gramineus acorus_gramineus_AGRA_17948
acorus_gramineus_AGRA_17985 acorus_gramineus acorus_gramineus_AGRA_17985
acorus_gramineus_AGRA_17986 acorus_gramineus acorus_gramineus_AGRA_17986
acorus_gramineus_AGRA_17988 acorus_gramineus acorus_gramineus_AGRA_17988
acorus_gramineus_AGRA_17989 acorus_gramineus acorus_gramineus_AGRA_17989
acorus_gramineus_AGRA_17990 acorus_gramineus acorus_gramineus_AGRA_17990
acorus_gramineus_AGRA_17991 acorus_gramineus acorus_gramineus_AGRA_17991
acorus_gramineus_AGRA_17994 acorus_gramineus acorus_gramineus_AGRA_17994
acorus_gramineus_AGRA_17995 acorus_gramineus acorus_gramineus_AGRA_17995
acorus_gramineus_AGRA_18074 acorus_gramineus acorus_gramineus_AGRA_18074
acorus_gramineus_AGRA_18075 acorus_gramineus acorus_gramineus_AGRA_18075
acorus_gramineus_AGRA_18111 acorus_gramineus acorus_gramineus_AGRA_18111
acorus_gramineus_AGRA_18362 acorus_gramineus acorus_gramineus_AGRA_18362
acorus_gramineus_AGRA_18370 acorus_gramineus acorus_gramineus_AGRA_18370
acorus_gramineus_AGRA_18371 acorus_gramineus acorus_gramineus_AGRA_18371
acorus_gramineus_AGRA_18404 acorus_gramineus acorus_gramineus_AGRA_18404
acorus_gramineus_AGRA_18428 acorus_gramineus acorus_gramineus_AGRA_18428
acorus_gramineus_AGRA_18429 acorus_gramineus acorus_gramineus_AGRA_18429
acorus_gramineus_AGRA_18437 acorus_gramineus acorus_gramineus_AGRA_18437
acorus_gramineus_AGRA_18640 acorus_gramineus acorus_gramineus_AGRA_18640
acorus_gramineus_AGRA_18683 acorus_gramineus acorus_gramineus_AGRA_18683
acorus_gramineus_AGRA_18935 acorus_gramineus acorus_gramineus_AGRA_18935
acorus_gramineus_AGRA_19078 acorus_gramineus acorus_gramineus_AGRA_19078
acorus_gramineus_AGRA_19146 acorus_gramineus acorus_gramineus_AGRA_19146
acorus_gramineus_AGRA_19148 acorus_gramineus acorus_gramineus_AGRA_19148
acorus_gramineus_AGRA_19149 acorus_gramineus acorus_gramineus_AGRA_19149
acorus_gramineus_AGRA_19150 acorus_gramineus acorus_gramineus_AGRA_19150
acorus_gramineus_AGRA_19151 acorus_gramineus acorus_gramineus_AGRA_19151