PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL200
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H2695
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL772
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT558
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR365
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS1035
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR304
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Basal angiosperms (5929)
Current lineage filter: Basal angiosperms. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits5929
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Annona cherimola
Brasenia schreberi
Cinnamomum kanehirae
Chloranthus sessilifolius
Aristolochia contorta
Cinnamomum camphora
Amborella trichopoda
Piper nigrum
Liriodendron chinense
Saururus chinensis
Lineage Summary
Basal angiosperms
5929
Module Gene List
Reset
GeneSpeciesProtein ID
annona_cherimola_Anche102Scf0004g0000150.1 annona_cherimola annona_cherimola_Anche102Scf0004g0000150.1
annona_cherimola_Anche102Scf0004g0000180.1 annona_cherimola annona_cherimola_Anche102Scf0004g0000180.1
annona_cherimola_Anche102Scf0004g0002290.1 annona_cherimola annona_cherimola_Anche102Scf0004g0002290.1
annona_cherimola_Anche102Scf0005g0002110.1 annona_cherimola annona_cherimola_Anche102Scf0005g0002110.1
annona_cherimola_Anche102Scf0006g0000020.1 annona_cherimola annona_cherimola_Anche102Scf0006g0000020.1
annona_cherimola_Anche102Scf0007g0000950.1 annona_cherimola annona_cherimola_Anche102Scf0007g0000950.1
annona_cherimola_Anche102Scf0007g0000960.1 annona_cherimola annona_cherimola_Anche102Scf0007g0000960.1
annona_cherimola_Anche102Scf0007g0000980.1 annona_cherimola annona_cherimola_Anche102Scf0007g0000980.1
annona_cherimola_Anche102Scf0008g0000820.1 annona_cherimola annona_cherimola_Anche102Scf0008g0000820.1
annona_cherimola_Anche102Scf0009g0000890.1 annona_cherimola annona_cherimola_Anche102Scf0009g0000890.1
annona_cherimola_Anche102Scf0009g0000940.1 annona_cherimola annona_cherimola_Anche102Scf0009g0000940.1
annona_cherimola_Anche102Scf0009g0000950.1 annona_cherimola annona_cherimola_Anche102Scf0009g0000950.1
annona_cherimola_Anche102Scf0009g0000970.1 annona_cherimola annona_cherimola_Anche102Scf0009g0000970.1
annona_cherimola_Anche102Scf0010g0001390.1 annona_cherimola annona_cherimola_Anche102Scf0010g0001390.1
annona_cherimola_Anche102Scf0014g0000710.1 annona_cherimola annona_cherimola_Anche102Scf0014g0000710.1
annona_cherimola_Anche102Scf0015g0000460.1 annona_cherimola annona_cherimola_Anche102Scf0015g0000460.1
annona_cherimola_Anche102Scf0016g0000290.1 annona_cherimola annona_cherimola_Anche102Scf0016g0000290.1
annona_cherimola_Anche102Scf0016g0000300.1 annona_cherimola annona_cherimola_Anche102Scf0016g0000300.1
annona_cherimola_Anche102Scf0016g0000330.1 annona_cherimola annona_cherimola_Anche102Scf0016g0000330.1
annona_cherimola_Anche102Scf0016g0000380.1 annona_cherimola annona_cherimola_Anche102Scf0016g0000380.1
annona_cherimola_Anche102Scf0016g0000410.1 annona_cherimola annona_cherimola_Anche102Scf0016g0000410.1
annona_cherimola_Anche102Scf0023g0000060.1 annona_cherimola annona_cherimola_Anche102Scf0023g0000060.1
annona_cherimola_Anche102Scf0024g0000850.1 annona_cherimola annona_cherimola_Anche102Scf0024g0000850.1
annona_cherimola_Anche102Scf0028g0000430.1 annona_cherimola annona_cherimola_Anche102Scf0028g0000430.1
annona_cherimola_Anche102Scf0030g0000430.1 annona_cherimola annona_cherimola_Anche102Scf0030g0000430.1
annona_cherimola_Anche102Scf0037g0000210.1 annona_cherimola annona_cherimola_Anche102Scf0037g0000210.1
annona_cherimola_Anche102Scf0042g0000190.1 annona_cherimola annona_cherimola_Anche102Scf0042g0000190.1
annona_cherimola_Anche102Scf0062g0000120.1 annona_cherimola annona_cherimola_Anche102Scf0062g0000120.1
annona_cherimola_Anche102Scf0080g0000070.1 annona_cherimola annona_cherimola_Anche102Scf0080g0000070.1
annona_cherimola_Anche102Scf0088g0000020.1 annona_cherimola annona_cherimola_Anche102Scf0088g0000020.1