PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL1925
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H8972
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL3447
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT2437
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR2553
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS3381
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR1984
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Bryophytes (24699)
Current lineage filter: Bryophytes. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits24699
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Anthoceros agrestis Oxford
Bryum knowltonii
Anthoceros punctatus
Archidium alternifolium
Calliergon cordifolium
Buxbaumia aphylla
Fossombronia
Bryoxiphium norvegicum
Funaria hygrometrica
Acrobolbus urvilleanus
Lineage Summary
Bryophytes
24699
Module Gene List
Reset
GeneSpeciesProtein ID
AagrOXFutg000002l0009200.4 anthoceros_agrestis_oxford AagrOXFutg000002l0009200.4
AagrOXFutg000002l0009890.1 anthoceros_agrestis_oxford AagrOXFutg000002l0009890.1
AagrOXFutg000002l0009890.2 anthoceros_agrestis_oxford AagrOXFutg000002l0009890.2
AagrOXFutg000002l0009890.3 anthoceros_agrestis_oxford AagrOXFutg000002l0009890.3
AagrOXFutg000002l0009890.4 anthoceros_agrestis_oxford AagrOXFutg000002l0009890.4
AagrOXFutg000002l0010340.1 anthoceros_agrestis_oxford AagrOXFutg000002l0010340.1
AagrOXFutg000002l0010380.1 anthoceros_agrestis_oxford AagrOXFutg000002l0010380.1
AagrOXFutg000002l0011270.1 anthoceros_agrestis_oxford AagrOXFutg000002l0011270.1
AagrOXFutg000002l0011480.1 anthoceros_agrestis_oxford AagrOXFutg000002l0011480.1
AagrOXFutg000002l0011760.1 anthoceros_agrestis_oxford AagrOXFutg000002l0011760.1
AagrOXFutg000002l0011770.1 anthoceros_agrestis_oxford AagrOXFutg000002l0011770.1
AagrOXFutg000002l0011790.1 anthoceros_agrestis_oxford AagrOXFutg000002l0011790.1
AagrOXFutg000002l0011800.1 anthoceros_agrestis_oxford AagrOXFutg000002l0011800.1
AagrOXFutg000003l0012280.1 anthoceros_agrestis_oxford AagrOXFutg000003l0012280.1
AagrOXFutg000003l0012570.1 anthoceros_agrestis_oxford AagrOXFutg000003l0012570.1
AagrOXFutg000003l0012570.2 anthoceros_agrestis_oxford AagrOXFutg000003l0012570.2
AagrOXFutg000003l0012570.3 anthoceros_agrestis_oxford AagrOXFutg000003l0012570.3
AagrOXFutg000003l0012570.4 anthoceros_agrestis_oxford AagrOXFutg000003l0012570.4
AagrOXFutg000003l0012570.5 anthoceros_agrestis_oxford AagrOXFutg000003l0012570.5
AagrOXFutg000003l0012570.6 anthoceros_agrestis_oxford AagrOXFutg000003l0012570.6
AagrOXFutg000003l0012580.1 anthoceros_agrestis_oxford AagrOXFutg000003l0012580.1
AagrOXFutg000003l0012580.2 anthoceros_agrestis_oxford AagrOXFutg000003l0012580.2
AagrOXFutg000003l0012880.1 anthoceros_agrestis_oxford AagrOXFutg000003l0012880.1
AagrOXFutg000003l0012880.2 anthoceros_agrestis_oxford AagrOXFutg000003l0012880.2
AagrOXFutg000003l0012880.3 anthoceros_agrestis_oxford AagrOXFutg000003l0012880.3
AagrOXFutg000003l0012990.1 anthoceros_agrestis_oxford AagrOXFutg000003l0012990.1
AagrOXFutg000003l0014340.1 anthoceros_agrestis_oxford AagrOXFutg000003l0014340.1
AagrOXFutg000003l0014940.1 anthoceros_agrestis_oxford AagrOXFutg000003l0014940.1
AagrOXFutg000003l0015030.1 anthoceros_agrestis_oxford AagrOXFutg000003l0015030.1
AagrOXFutg000003l0015270.1 anthoceros_agrestis_oxford AagrOXFutg000003l0015270.1