PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL146
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H1115
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL584
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT251
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR200
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS458
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR135
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Gymnosperms (2889)
Current lineage filter: Gymnosperms. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits2889
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Ginkgo biloba
Abies alba
Gnetum montanum
Pinus taeda
Taxus chinensis
Welwitschia mirabilis
Lineage Summary
Gymnosperms
2889
Module Gene List
Reset
GeneSpeciesProtein ID
Aalbaalba5_s000071830052900.1 abies_alba Aalbaalba5_s000071830052900.1
Aalbaalba5_s000073800054340.1 abies_alba Aalbaalba5_s000073800054340.1
Aalbaalba5_s000080780058580.1 abies_alba Aalbaalba5_s000080780058580.1
Aalbaalba5_s000082300059740.1 abies_alba Aalbaalba5_s000082300059740.1
Aalbaalba5_s000095920067950.1 abies_alba Aalbaalba5_s000095920067950.1
Aalbaalba5_s000101410071070.1 abies_alba Aalbaalba5_s000101410071070.1
Aalbaalba5_s000103510072320.1 abies_alba Aalbaalba5_s000103510072320.1
Aalbaalba5_s000105190072980.1 abies_alba Aalbaalba5_s000105190072980.1
Aalbaalba5_s000106630073770.1 abies_alba Aalbaalba5_s000106630073770.1
Aalbaalba5_s000108480074750.1 abies_alba Aalbaalba5_s000108480074750.1
Aalbaalba5_s000111500076220.1 abies_alba Aalbaalba5_s000111500076220.1
Aalbaalba5_s000113380077120.1 abies_alba Aalbaalba5_s000113380077120.1
Aalbaalba5_s000116630078960.1 abies_alba Aalbaalba5_s000116630078960.1
Aalbaalba5_s000118550079880.1 abies_alba Aalbaalba5_s000118550079880.1
Aalbaalba5_s000128790085610.1 abies_alba Aalbaalba5_s000128790085610.1
Aalbaalba5_s000133190087800.1 abies_alba Aalbaalba5_s000133190087800.1
Aalbaalba5_s000133240087830.1 abies_alba Aalbaalba5_s000133240087830.1
Aalbaalba5_s000133240087850.1 abies_alba Aalbaalba5_s000133240087850.1
Aalbaalba5_s000147040094900.1 abies_alba Aalbaalba5_s000147040094900.1
Aalbaalba5_s000173100108430.1 abies_alba Aalbaalba5_s000173100108430.1
Aalbaalba5_s000177310110550.1 abies_alba Aalbaalba5_s000177310110550.1
Aalbaalba5_s000180240112030.1 abies_alba Aalbaalba5_s000180240112030.1
Aalbaalba5_s000185910115110.1 abies_alba Aalbaalba5_s000185910115110.1
Aalbaalba5_s000191720118250.1 abies_alba Aalbaalba5_s000191720118250.1
Aalbaalba5_s000194020119230.1 abies_alba Aalbaalba5_s000194020119230.1
Aalbaalba5_s000201820122950.1 abies_alba Aalbaalba5_s000201820122950.1
Aalbaalba5_s000202610123360.1 abies_alba Aalbaalba5_s000202610123360.1
Aalbaalba5_s000207370125560.1 abies_alba Aalbaalba5_s000207370125560.1
Aalbaalba5_s000207800125740.1 abies_alba Aalbaalba5_s000207800125740.1
Aalbaalba5_s000219310130620.1 abies_alba Aalbaalba5_s000219310130620.1