PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL200
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H2695
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL772
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT558
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR365
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS1035
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR304
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Basal angiosperms (5929)
Current lineage filter: Basal angiosperms. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits5929
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Annona cherimola
Brasenia schreberi
Cinnamomum kanehirae
Chloranthus sessilifolius
Aristolochia contorta
Cinnamomum camphora
Amborella trichopoda
Piper nigrum
Liriodendron chinense
Saururus chinensis
Lineage Summary
Basal angiosperms
5929
Module Gene List
Reset
GeneSpeciesProtein ID
cinnamomum_camphora_GWHPBGXC014279 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC014279
cinnamomum_camphora_GWHPBGXC014281 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC014281
cinnamomum_camphora_GWHPBGXC014438 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC014438
cinnamomum_camphora_GWHPBGXC014440 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC014440
cinnamomum_camphora_GWHPBGXC014443 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC014443
cinnamomum_camphora_GWHPBGXC014446 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC014446
cinnamomum_camphora_GWHPBGXC014693 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC014693
cinnamomum_camphora_GWHPBGXC014763 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC014763
cinnamomum_camphora_GWHPBGXC014880 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC014880
cinnamomum_camphora_GWHPBGXC015156 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC015156
cinnamomum_camphora_GWHPBGXC015572 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC015572
cinnamomum_camphora_GWHPBGXC015589 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC015589
cinnamomum_camphora_GWHPBGXC015826 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC015826
cinnamomum_camphora_GWHPBGXC015827 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC015827
cinnamomum_camphora_GWHPBGXC015973 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC015973
cinnamomum_camphora_GWHPBGXC015983 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC015983
cinnamomum_camphora_GWHPBGXC016271 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC016271
cinnamomum_camphora_GWHPBGXC016312 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC016312
cinnamomum_camphora_GWHPBGXC016436 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC016436
cinnamomum_camphora_GWHPBGXC017097 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC017097
cinnamomum_camphora_GWHPBGXC017098 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC017098
cinnamomum_camphora_GWHPBGXC017102 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC017102
cinnamomum_camphora_GWHPBGXC017113 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC017113
cinnamomum_camphora_GWHPBGXC017350 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC017350
cinnamomum_camphora_GWHPBGXC017393 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC017393
cinnamomum_camphora_GWHPBGXC017419 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC017419
cinnamomum_camphora_GWHPBGXC017435 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC017435
cinnamomum_camphora_GWHPBGXC017737 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC017737
cinnamomum_camphora_GWHPBGXC017889 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC017889
cinnamomum_camphora_GWHPBGXC018009 cinnamomum_camphora cinnamomum_camphora_GWHPBGXC018009