PlantSME Plant secondary metabolism enzyme database
Flavonoid portable pathway

Flavonoid portable pathway

Category：Flavonoid pathway

Flavonoid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Flavonoid Reaction Route
Phenylpropanoid entry, flavonoid scaffold, and anthocyanin branches. The flavonoid pathway is branched; this view arranges the main scaffold and common branches into a readable representative route without forcing all branches into one linear pathway.
9 curated steps/modules
From Phenylpropanoid Entry To Flavonoid Scaffold
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination to the cinnamate entry point
PAL7015
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL commits L-phenylalanine to the phenylpropanoid entry route that supplies the flavonoid acyl donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Para-hydroxylation of cinnamate
C4H464
Product
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A hydroxylates cinnamate to p-coumarate, a required phenylpropanoid step toward the flavonoid donor.
03
Substrate
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the flavonoid acyl donor
4CL25907
Product
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL activates p-coumarate to p-coumaroyl-CoA for CHS-mediated flavonoid scaffold formation.
04
Substrate
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
Malonyl-CoA
C24H38N7O19P3S
HOOC-CH2-C(=O)-SCoA
Condensation of the C6-C3-C6 scaffold
CHS11738
Product
Naringenin chalcone
C15H12O5
HO-Ar-CO-CH=CH-Ar-(OH)2
CHS condenses one p-coumaroyl-CoA with three malonyl-CoA units to form a chalcone scaffold.
05
Substrate
Naringenin chalcone
C15H12O5
HO-Ar-CO-CH=CH-Ar-(OH)2
Chalcone cyclization
CHI3089
Product
Naringenin
C15H12O5
flavanone C6-C3-C6 ring
CHI converts the open-chain chalcone into the flavanone core.
06
Substrate
Naringenin
C15H12O5
flavanone C6-C3-C6 ring
C-ring 3-hydroxylation to dihydroflavonols
F3H4697
Product
Dihydrokaempferol
C15H12O6
dihydroflavonol C-ring
F3H is a 2-oxoglutarate-dependent dioxygenase that converts flavanones into the dihydroflavonol pool.
07
Substrate
Flavanones/dihydroflavonols
C15H12O5-6
C6-C3-C6 oxygen heterocycle
B-ring hydroxylation shapes flavonoid hydroxylation patterns
F3'H/CYP75B1332 F3'5'H/CYP75A247
Product
B-ring hydroxylated flavonoid intermediates
C15H12O6-7
3'/3'5'-hydroxylated flavonoids
CYP75B/F3'H and CYP75A/F3'5'H alter B-ring hydroxylation and generate precursors for quercetin- and myricetin-type branches.
Flavone, Anthocyanin, And Proanthocyanidin Branches
08
Substrate
Flavanones/dihydroflavonols
C15 flavonoids
C6-C3-C6 oxygen heterocycle
Flavone, isoflavonoid, and flavonol branches
FNS359 IFS541 IFR11814 FLS124
Product
Flavones/isoflavones/flavonols
C15H10O5-7
oxidized C6-C3-C6 flavonoids
Branch enzymes route shared intermediates into distinct flavonoid subclasses.
09
Substrate
Dihydroflavonols
C15H12O6-7
dihydroflavonol C-ring
Anthocyanin and proanthocyanidin direction
DFR1310 ANS/LDOX1019 UFGT106747 ANR1183
Product
Anthocyanin glycosides/proanthocyanidins
C15 glycosides/polymers
flavylium-glycoside / flavan-3-ol polymer
DFR/ANS/UFGT/ANR route the dihydroflavonol pool toward pigments and condensed tannins.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Algae (327) Bryophytes (11036) Lycophytes/Ferns (622) Gymnosperms (2088) Basal angiosperms (2815) Monocots (36340) Eudicots (124277)
Algae
Hits327
Bryophytes
Hits11036
Lycophytes/Ferns
Hits622
Gymnosperms
Hits2088
Basal angiosperms
Hits2815
Monocots
Hits36340
Eudicots
Hits124277
Species Distribution
Triticum turgidum
Triticum aestivum
Hordeum vulgare
Aegilops tauschii
Rhynchospora pubera
Avena sativa
Fragaria ananassa
Eragrostis nindensis
Pinus taeda
Diospyros kaki
Lineage Summary
Algae
327
Bryophytes
11036
Lycophytes/Ferns
622
Gymnosperms
2088
Basal angiosperms
2815
Monocots
36340
Eudicots
124277
Module Gene List
GeneSpeciesProtein ID
actinidia_zhejiangensis_GWHPCBQB080793 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB080793
actinidia_zhejiangensis_GWHPCBQB082201 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB082201
actinidia_zhejiangensis_GWHPCBQB082651 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB082651
actinidia_zhejiangensis_GWHPCBQB082725 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB082725
actinidia_zhejiangensis_GWHPCBQB083093 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083093
actinidia_zhejiangensis_GWHPCBQB083151 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083151
actinidia_zhejiangensis_GWHPCBQB083318 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083318
actinidia_zhejiangensis_GWHPCBQB083359 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083359
actinidia_zhejiangensis_GWHPCBQB083447 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083447
actinidia_zhejiangensis_GWHPCBQB083503 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083503
actinidia_zhejiangensis_GWHPCBQB083728 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083728
actinidia_zhejiangensis_GWHPCBQB083730 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083730
actinidia_zhejiangensis_GWHPCBQB083731 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083731
actinidia_zhejiangensis_GWHPCBQB083732 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083732
actinidia_zhejiangensis_GWHPCBQB083733 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083733
actinidia_zhejiangensis_GWHPCBQB083735 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083735
actinidia_zhejiangensis_GWHPCBQB083833 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB083833
actinidia_zhejiangensis_GWHPCBQB084120 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB084120
actinidia_zhejiangensis_GWHPCBQB084121 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB084121
actinidia_zhejiangensis_GWHPCBQB084326 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB084326
actinidia_zhejiangensis_GWHPCBQB084407 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB084407
actinidia_zhejiangensis_GWHPCBQB084408 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB084408
actinidia_zhejiangensis_GWHPCBQB084464 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB084464
actinidia_zhejiangensis_GWHPCBQB084909 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB084909
actinidia_zhejiangensis_GWHPCBQB085135 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB085135
actinidia_zhejiangensis_GWHPCBQB085136 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB085136
actinidia_zhejiangensis_GWHPCBQB085137 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB085137
actinidia_zhejiangensis_GWHPCBQB085338 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB085338
actinidia_zhejiangensis_GWHPCBQB085464 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB085464
actinidia_zhejiangensis_GWHPCBQB085529 actinidia_zhejiangensis actinidia_zhejiangensis_GWHPCBQB085529