PlantSME Plant secondary metabolism enzyme database
Phenylpropanoid portable pathway

Phenylpropanoid portable pathway

Category：Phenylpropanoid pathway

Phenylpropanoid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Phenylpropanoid Reaction Route
Entry backbone to monolignol/lignin branches. Substrates, products, and condensed structural formulae show representative conversions; resolved reactions are shown as single enzymes, whereas multi-enzyme branches are shown as curated modules. Member counts come from public annotations.
6 curated steps/modules
Entry Backbone And Lignin Direction
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination to form the phenylpropene acid scaffold
PAL1910
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL commits the amino-acid substrate to phenylpropanoid metabolism.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Para-hydroxylation of the aromatic ring
C4H401
Product
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A introduces the 4-hydroxyl group for downstream CoA activation.
03
Substrate
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation and activation
4CL3434
Product
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL converts the free acid into a thioester used by condensation, acyltransfer, and reduction reactions.
04
Substrate
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Hydroxylation, acyl transfer, and methylation
HCT1920 C3'H/CYP98A1929 CSE2414 CCoAOMT382
Product
Feruloyl-CoA-type intermediates
C31H40N7O19P3S
3-MeO-4-HO-C6H3-CH=CH-C(=O)-SCoA
This segment remodels the p-coumaroyl scaffold into caffeoyl/feruloyl-type intermediates.
05
Substrate
Hydroxycinnamoyl-CoA
C30-31 CoA thioesters
Ar-CH=CH-C(=O)-SCoA
Reduction and S/G monolignol formation
CCR2707 CAD2978 F5H/CYP84A171 COMT1825
Product
Coniferyl/sinapyl alcohol
C10H12O3 / C11H14O4
Ar-CH=CH-CH2OH
CCR/CAD and related steps route CoA thioesters toward monolignol monomers.
06
Substrate
Monolignols
C9-C11 phenylpropanoids
Ar-CH=CH-CH2OH
Oxidative coupling and polymerization
LAC3730 POD14559
Product
Lignin polymer
(C9 unit)n
[Ar-C3]n ether/C-C polymer
LAC/POD oxidatively couple monolignols into lignin polymers.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Bryophytes (38360)
Current lineage filter: Bryophytes. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits38360
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Bryum knowltonii
Anthoceros agrestis Oxford
Anthoceros punctatus
Buxbaumia aphylla
Calliergon cordifolium
Archidium alternifolium
Funaria hygrometrica
Andreaea rupestris
Acrobolbus urvilleanus
Bryoxiphium norvegicum
Lineage Summary
Bryophytes
38360
Module Gene List
Reset
GeneSpeciesProtein ID
Asubscaffold_90271540 aerobryopsis_subdivergens Asubscaffold_90271540
Asubscaffold_90271860 aerobryopsis_subdivergens Asubscaffold_90271860
Asubscaffold_90273160 aerobryopsis_subdivergens Asubscaffold_90273160
Asubscaffold_90274460 aerobryopsis_subdivergens Asubscaffold_90274460
Asubscaffold_90279270 aerobryopsis_subdivergens Asubscaffold_90279270
Asubscaffold_90280750 aerobryopsis_subdivergens Asubscaffold_90280750
Arupctg000278_np121212120001860 andreaea_rupestris Arupctg000278_np121212120001860
Arupctg000506_np121212120007440 andreaea_rupestris Arupctg000506_np121212120007440
Arupctg000563_np121212120007910 andreaea_rupestris Arupctg000563_np121212120007910
Arupctg000563_np121212120007920 andreaea_rupestris Arupctg000563_np121212120007920
Arupctg000563_np121212120008430 andreaea_rupestris Arupctg000563_np121212120008430
Arupctg000563_np121212120008650 andreaea_rupestris Arupctg000563_np121212120008650
Arupctg000564_np121212120009040 andreaea_rupestris Arupctg000564_np121212120009040
Arupctg000565_np121212120009420 andreaea_rupestris Arupctg000565_np121212120009420
Arupctg000565_np121212120009430 andreaea_rupestris Arupctg000565_np121212120009430
Arupctg000580_np121212120010870 andreaea_rupestris Arupctg000580_np121212120010870
Arupctg000580_np121212120011430 andreaea_rupestris Arupctg000580_np121212120011430
Arupctg000581_np121212120011510 andreaea_rupestris Arupctg000581_np121212120011510
Arupctg000598_np121212120013160 andreaea_rupestris Arupctg000598_np121212120013160
Arupctg000602_np121212120014020 andreaea_rupestris Arupctg000602_np121212120014020
Arupctg000602_np121212120014030 andreaea_rupestris Arupctg000602_np121212120014030
Arupctg000602_np121212120014050 andreaea_rupestris Arupctg000602_np121212120014050
Arupctg000603_np121212120014420 andreaea_rupestris Arupctg000603_np121212120014420
Arupctg000611_np121212120017250 andreaea_rupestris Arupctg000611_np121212120017250
Arupctg000614_np121212120017580 andreaea_rupestris Arupctg000614_np121212120017580
Arupctg000615_np121212120017800 andreaea_rupestris Arupctg000615_np121212120017800
Arupctg000626_np121212120019660 andreaea_rupestris Arupctg000626_np121212120019660
Arupctg000626_np121212120019790 andreaea_rupestris Arupctg000626_np121212120019790
Arupctg000627_np121212120020170 andreaea_rupestris Arupctg000627_np121212120020170
Arupctg000633_np121212120021630 andreaea_rupestris Arupctg000633_np121212120021630