PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL1925
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H8972
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL3447
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT2437
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR2553
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS3381
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR1984
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Bryophytes (24699)
Current lineage filter: Bryophytes. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits24699
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Anthoceros agrestis Oxford
Bryum knowltonii
Anthoceros punctatus
Archidium alternifolium
Calliergon cordifolium
Buxbaumia aphylla
Fossombronia
Bryoxiphium norvegicum
Funaria hygrometrica
Acrobolbus urvilleanus
Lineage Summary
Bryophytes
24699
Module Gene List
Reset
GeneSpeciesProtein ID
Arupctg000906_np121212120084990 andreaea_rupestris Arupctg000906_np121212120084990
Arupctg000906_np121212120085000 andreaea_rupestris Arupctg000906_np121212120085000
Arupctg000906_np121212120085010 andreaea_rupestris Arupctg000906_np121212120085010
Arupctg000906_np121212120085020 andreaea_rupestris Arupctg000906_np121212120085020
Arupctg000933_np121212120090010 andreaea_rupestris Arupctg000933_np121212120090010
Arupctg000976_np121212120094820 andreaea_rupestris Arupctg000976_np121212120094820
Arupctg000976_np121212120094830 andreaea_rupestris Arupctg000976_np121212120094830
Arupctg000984_np121212120096600 andreaea_rupestris Arupctg000984_np121212120096600
Arupctg000984_np121212120097290 andreaea_rupestris Arupctg000984_np121212120097290
Arupctg000990_np121212120097980 andreaea_rupestris Arupctg000990_np121212120097980
Arupctg001017_np121212120100660 andreaea_rupestris Arupctg001017_np121212120100660
Arupctg001099_np121212120110290 andreaea_rupestris Arupctg001099_np121212120110290
Arupctg001099_np121212120111110 andreaea_rupestris Arupctg001099_np121212120111110
Arupctg001105_np121212120111550 andreaea_rupestris Arupctg001105_np121212120111550
Arupctg001105_np121212120111660 andreaea_rupestris Arupctg001105_np121212120111660
Arupctg001105_np121212120111760 andreaea_rupestris Arupctg001105_np121212120111760
Arupctg001107_np121212120112190 andreaea_rupestris Arupctg001107_np121212120112190
Arupctg001107_np121212120112200 andreaea_rupestris Arupctg001107_np121212120112200
Arupctg001110_np121212120113840 andreaea_rupestris Arupctg001110_np121212120113840
Arupctg001112_np121212120114690 andreaea_rupestris Arupctg001112_np121212120114690
Arupctg001142_np121212120116230 andreaea_rupestris Arupctg001142_np121212120116230
Arupctg001148_np121212120118790 andreaea_rupestris Arupctg001148_np121212120118790
Arupctg001168_np121212120119280 andreaea_rupestris Arupctg001168_np121212120119280
Arupctg001173_np121212120120740 andreaea_rupestris Arupctg001173_np121212120120740
Arupctg001185_np121212120122520 andreaea_rupestris Arupctg001185_np121212120122520
Arupctg001185_np121212120122530 andreaea_rupestris Arupctg001185_np121212120122530
Arupctg001185_np121212120122540 andreaea_rupestris Arupctg001185_np121212120122540
Arupctg001215_np121212120124920 andreaea_rupestris Arupctg001215_np121212120124920
Arupctg001274_np121212120131390 andreaea_rupestris Arupctg001274_np121212120131390
Arupctg001283_np121212120133350 andreaea_rupestris Arupctg001283_np121212120133350