PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL1925
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H8972
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL3447
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT2437
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR2553
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS3381
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR1984
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Bryophytes (24699)
Current lineage filter: Bryophytes. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits24699
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Anthoceros agrestis Oxford
Bryum knowltonii
Anthoceros punctatus
Archidium alternifolium
Calliergon cordifolium
Buxbaumia aphylla
Fossombronia
Bryoxiphium norvegicum
Funaria hygrometrica
Acrobolbus urvilleanus
Lineage Summary
Bryophytes
24699
Module Gene List
Reset
GeneSpeciesProtein ID
Arupctg001284_np121212120134620 andreaea_rupestris Arupctg001284_np121212120134620
Arupctg001285_np121212120134660 andreaea_rupestris Arupctg001285_np121212120134660
Arupctg001285_np121212120134790 andreaea_rupestris Arupctg001285_np121212120134790
Arupctg001285_np121212120136160 andreaea_rupestris Arupctg001285_np121212120136160
Arupctg001286_np121212120136360 andreaea_rupestris Arupctg001286_np121212120136360
Arupctg001298_np121212120137800 andreaea_rupestris Arupctg001298_np121212120137800
Arupctg001336_np121212120145980 andreaea_rupestris Arupctg001336_np121212120145980
Arupctg001336_np121212120145990 andreaea_rupestris Arupctg001336_np121212120145990
Arupctg001359_np121212120151810 andreaea_rupestris Arupctg001359_np121212120151810
Arupctg001359_np121212120151820 andreaea_rupestris Arupctg001359_np121212120151820
Arupctg001417_np121212120158580 andreaea_rupestris Arupctg001417_np121212120158580
Arupctg001417_np121212120159050 andreaea_rupestris Arupctg001417_np121212120159050
Arupctg001417_np121212120159060 andreaea_rupestris Arupctg001417_np121212120159060
Arupctg001420_np121212120160250 andreaea_rupestris Arupctg001420_np121212120160250
Arupctg001422_np121212120160990 andreaea_rupestris Arupctg001422_np121212120160990
Arupctg001443_np121212120162750 andreaea_rupestris Arupctg001443_np121212120162750
Arupctg001443_np121212120162770 andreaea_rupestris Arupctg001443_np121212120162770
Arupctg001454_np121212120166000 andreaea_rupestris Arupctg001454_np121212120166000
Arupctg001454_np121212120166010 andreaea_rupestris Arupctg001454_np121212120166010
Arupctg001455_np121212120166340 andreaea_rupestris Arupctg001455_np121212120166340
Arupctg001455_np121212120166990 andreaea_rupestris Arupctg001455_np121212120166990
Arupctg001459_np121212120167840 andreaea_rupestris Arupctg001459_np121212120167840
Arupctg001459_np121212120167920 andreaea_rupestris Arupctg001459_np121212120167920
Arupctg001459_np121212120167930 andreaea_rupestris Arupctg001459_np121212120167930
Arupctg001459_np121212120167980 andreaea_rupestris Arupctg001459_np121212120167980
Arupctg001489_np121212120171560 andreaea_rupestris Arupctg001489_np121212120171560
Arupctg001489_np121212120172420 andreaea_rupestris Arupctg001489_np121212120172420
Arupctg001490_np121212120173580 andreaea_rupestris Arupctg001490_np121212120173580
Arupctg001518_np121212120176320 andreaea_rupestris Arupctg001518_np121212120176320
Arupctg001519_np121212120176850 andreaea_rupestris Arupctg001519_np121212120176850