PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL1925
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H8972
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL3447
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT2437
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR2553
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS3381
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR1984
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Bryophytes (24699)
Current lineage filter: Bryophytes. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits24699
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Anthoceros agrestis Oxford
Bryum knowltonii
Anthoceros punctatus
Archidium alternifolium
Calliergon cordifolium
Buxbaumia aphylla
Fossombronia
Bryoxiphium norvegicum
Funaria hygrometrica
Acrobolbus urvilleanus
Lineage Summary
Bryophytes
24699
Module Gene List
Reset
GeneSpeciesProtein ID
Arupctg001524_np121212120179100 andreaea_rupestris Arupctg001524_np121212120179100
Arupctg001543_np121212120180970 andreaea_rupestris Arupctg001543_np121212120180970
Arupctg001562_np121212120183310 andreaea_rupestris Arupctg001562_np121212120183310
Arupctg001584_np121212120184800 andreaea_rupestris Arupctg001584_np121212120184800
Arupctg001603_np121212120188300 andreaea_rupestris Arupctg001603_np121212120188300
Arupctg001615_np121212120189140 andreaea_rupestris Arupctg001615_np121212120189140
Arupctg001617_np121212120190270 andreaea_rupestris Arupctg001617_np121212120190270
Arupctg001620_np121212120191570 andreaea_rupestris Arupctg001620_np121212120191570
Arupctg001638_np121212120196200 andreaea_rupestris Arupctg001638_np121212120196200
Arupctg001638_np121212120196210 andreaea_rupestris Arupctg001638_np121212120196210
Arupctg001638_np121212120196230 andreaea_rupestris Arupctg001638_np121212120196230
Arupctg001638_np121212120196240 andreaea_rupestris Arupctg001638_np121212120196240
Arupctg001638_np121212120196250 andreaea_rupestris Arupctg001638_np121212120196250
Arupctg001638_np121212120196270 andreaea_rupestris Arupctg001638_np121212120196270
Arupctg001638_np121212120196280 andreaea_rupestris Arupctg001638_np121212120196280
Arupctg001657_np121212120198880 andreaea_rupestris Arupctg001657_np121212120198880
Arupctg001662_np121212120200650 andreaea_rupestris Arupctg001662_np121212120200650
Arupctg001664_np121212120202170 andreaea_rupestris Arupctg001664_np121212120202170
Arupctg001677_np121212120206240 andreaea_rupestris Arupctg001677_np121212120206240
Arupctg001687_np121212120207950 andreaea_rupestris Arupctg001687_np121212120207950
Arupctg001704_np121212120209210 andreaea_rupestris Arupctg001704_np121212120209210
Arupctg001725_np121212120209450 andreaea_rupestris Arupctg001725_np121212120209450
Arupctg001742_np121212120212390 andreaea_rupestris Arupctg001742_np121212120212390
Arupctg001782_np121212120215370 andreaea_rupestris Arupctg001782_np121212120215370
Arupctg001792_np121212120216390 andreaea_rupestris Arupctg001792_np121212120216390
Arupctg001792_np121212120216400 andreaea_rupestris Arupctg001792_np121212120216400
Arupctg001799_np121212120219650 andreaea_rupestris Arupctg001799_np121212120219650
Arupctg001799_np121212120220830 andreaea_rupestris Arupctg001799_np121212120220830
Arupctg001820_np121212120223970 andreaea_rupestris Arupctg001820_np121212120223970
Arupctg001824_np121212120225080 andreaea_rupestris Arupctg001824_np121212120225080