PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL78
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H351
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL317
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT2109
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR1101
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS281
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR403
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Algae (4640)
Current lineage filter: Algae. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits4640
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Chara braunii
Botryococcus braunii
Chromochloris zofingiensis
Chlamydomonas reinhardtii
Cyanophora paradoxa
Dunaliella salina
Caulerpa lentillifera
Chlamydomonas schloesseri
Chlorokybus atmophyticus
Takakia lepidozioides
Lineage Summary
Algae
4640
Module Gene List
Reset
GeneSpeciesProtein ID
TlepHiC_scaffold_20050860 takakia_lepidozioides TlepHiC_scaffold_20050860
TlepHiC_scaffold_20051760 takakia_lepidozioides TlepHiC_scaffold_20051760
TlepHiC_scaffold_20051770 takakia_lepidozioides TlepHiC_scaffold_20051770
TlepHiC_scaffold_20051980 takakia_lepidozioides TlepHiC_scaffold_20051980
TlepHiC_scaffold_20052770 takakia_lepidozioides TlepHiC_scaffold_20052770
TlepHiC_scaffold_20055480 takakia_lepidozioides TlepHiC_scaffold_20055480
TlepHiC_scaffold_20056920 takakia_lepidozioides TlepHiC_scaffold_20056920
TlepHiC_scaffold_20058410 takakia_lepidozioides TlepHiC_scaffold_20058410
TlepHiC_scaffold_20073430 takakia_lepidozioides TlepHiC_scaffold_20073430
TlepHiC_scaffold_20075850 takakia_lepidozioides TlepHiC_scaffold_20075850
TlepHiC_scaffold_20075870 takakia_lepidozioides TlepHiC_scaffold_20075870
TlepHiC_scaffold_20080060 takakia_lepidozioides TlepHiC_scaffold_20080060
TlepHiC_scaffold_20085240 takakia_lepidozioides TlepHiC_scaffold_20085240
TlepHiC_scaffold_20087650 takakia_lepidozioides TlepHiC_scaffold_20087650
TlepHiC_scaffold_20090660 takakia_lepidozioides TlepHiC_scaffold_20090660
TlepHiC_scaffold_20091670 takakia_lepidozioides TlepHiC_scaffold_20091670
TlepHiC_scaffold_40103120 takakia_lepidozioides TlepHiC_scaffold_40103120
TlepHiC_scaffold_40108700 takakia_lepidozioides TlepHiC_scaffold_40108700
TlepHiC_scaffold_40108730 takakia_lepidozioides TlepHiC_scaffold_40108730
TlepHiC_scaffold_40110560 takakia_lepidozioides TlepHiC_scaffold_40110560
TlepHiC_scaffold_40110580 takakia_lepidozioides TlepHiC_scaffold_40110580
TlepHiC_scaffold_40112240 takakia_lepidozioides TlepHiC_scaffold_40112240
TlepHiC_scaffold_40116770 takakia_lepidozioides TlepHiC_scaffold_40116770
TlepHiC_scaffold_40117550 takakia_lepidozioides TlepHiC_scaffold_40117550
TlepHiC_scaffold_40120100 takakia_lepidozioides TlepHiC_scaffold_40120100
TlepHiC_scaffold_40120870 takakia_lepidozioides TlepHiC_scaffold_40120870
TlepHiC_scaffold_40122930 takakia_lepidozioides TlepHiC_scaffold_40122930
TlepHiC_scaffold_40122940 takakia_lepidozioides TlepHiC_scaffold_40122940
TlepHiC_scaffold_40135670 takakia_lepidozioides TlepHiC_scaffold_40135670
TlepHiC_scaffold_40136480 takakia_lepidozioides TlepHiC_scaffold_40136480