PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL78
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H351
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL317
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT2109
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR1101
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS281
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR403
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Algae (4640)
Current lineage filter: Algae. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits4640
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Chara braunii
Botryococcus braunii
Chromochloris zofingiensis
Chlamydomonas reinhardtii
Cyanophora paradoxa
Dunaliella salina
Caulerpa lentillifera
Chlamydomonas schloesseri
Chlorokybus atmophyticus
Takakia lepidozioides
Lineage Summary
Algae
4640
Module Gene List
Reset
GeneSpeciesProtein ID
TlepHiC_scaffold_40145280 takakia_lepidozioides TlepHiC_scaffold_40145280
TlepHiC_scaffold_40145960 takakia_lepidozioides TlepHiC_scaffold_40145960
TlepHiC_scaffold_40154740 takakia_lepidozioides TlepHiC_scaffold_40154740
TlepHiC_scaffold_40155930 takakia_lepidozioides TlepHiC_scaffold_40155930
TlepHiC_scaffold_40156000 takakia_lepidozioides TlepHiC_scaffold_40156000
TlepHiC_scaffold_40156140 takakia_lepidozioides TlepHiC_scaffold_40156140
TlepHiC_scaffold_40156360 takakia_lepidozioides TlepHiC_scaffold_40156360
TlepHiC_scaffold_40159090 takakia_lepidozioides TlepHiC_scaffold_40159090
TlepHiC_scaffold_40161770 takakia_lepidozioides TlepHiC_scaffold_40161770
TlepHiC_scaffold_40163570 takakia_lepidozioides TlepHiC_scaffold_40163570
TlepHiC_scaffold_40164100 takakia_lepidozioides TlepHiC_scaffold_40164100
TlepHiC_scaffold_40165840 takakia_lepidozioides TlepHiC_scaffold_40165840
TlepHiC_scaffold_40168080 takakia_lepidozioides TlepHiC_scaffold_40168080
TlepHiC_scaffold_40169970 takakia_lepidozioides TlepHiC_scaffold_40169970
TlepHiC_scaffold_40172720 takakia_lepidozioides TlepHiC_scaffold_40172720
TlepHiC_scaffold_50179380 takakia_lepidozioides TlepHiC_scaffold_50179380
TlepHiC_scaffold_50184330 takakia_lepidozioides TlepHiC_scaffold_50184330
TlepHiC_scaffold_50184340 takakia_lepidozioides TlepHiC_scaffold_50184340
TlepHiC_scaffold_50194310 takakia_lepidozioides TlepHiC_scaffold_50194310
TlepHiC_scaffold_50194330 takakia_lepidozioides TlepHiC_scaffold_50194330
TlepHiC_scaffold_50195480 takakia_lepidozioides TlepHiC_scaffold_50195480
TlepHiC_scaffold_50195940 takakia_lepidozioides TlepHiC_scaffold_50195940
TlepHiC_scaffold_50201730 takakia_lepidozioides TlepHiC_scaffold_50201730
TlepHiC_scaffold_50204010 takakia_lepidozioides TlepHiC_scaffold_50204010
TlepHiC_scaffold_50206270 takakia_lepidozioides TlepHiC_scaffold_50206270
TlepHiC_scaffold_50207460 takakia_lepidozioides TlepHiC_scaffold_50207460
TlepHiC_scaffold_50211060 takakia_lepidozioides TlepHiC_scaffold_50211060
TlepHiC_scaffold_50211110 takakia_lepidozioides TlepHiC_scaffold_50211110
TlepHiC_scaffold_50211250 takakia_lepidozioides TlepHiC_scaffold_50211250
TlepHiC_scaffold_50211990 takakia_lepidozioides TlepHiC_scaffold_50211990