PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL78
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H351
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL317
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT2109
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR1101
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS281
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR403
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Algae (4640)
Current lineage filter: Algae. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits4640
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Chara braunii
Botryococcus braunii
Chromochloris zofingiensis
Chlamydomonas reinhardtii
Cyanophora paradoxa
Dunaliella salina
Caulerpa lentillifera
Chlamydomonas schloesseri
Chlorokybus atmophyticus
Takakia lepidozioides
Lineage Summary
Algae
4640
Module Gene List
Reset
GeneSpeciesProtein ID
TlepHiC_scaffold_50212090 takakia_lepidozioides TlepHiC_scaffold_50212090
TlepHiC_scaffold_50214610 takakia_lepidozioides TlepHiC_scaffold_50214610
TlepHiC_scaffold_50215560 takakia_lepidozioides TlepHiC_scaffold_50215560
TlepHiC_scaffold_50215570 takakia_lepidozioides TlepHiC_scaffold_50215570
TlepHiC_scaffold_50215590 takakia_lepidozioides TlepHiC_scaffold_50215590
TlepHiC_scaffold_50215600 takakia_lepidozioides TlepHiC_scaffold_50215600
TlepHiC_scaffold_50215740 takakia_lepidozioides TlepHiC_scaffold_50215740
TlepHiC_scaffold_50215860 takakia_lepidozioides TlepHiC_scaffold_50215860
TlepHiC_scaffold_50215870 takakia_lepidozioides TlepHiC_scaffold_50215870
TlepHiC_scaffold_50216290 takakia_lepidozioides TlepHiC_scaffold_50216290
TlepHiC_scaffold_50219810 takakia_lepidozioides TlepHiC_scaffold_50219810
TlepHiC_scaffold_60222240 takakia_lepidozioides TlepHiC_scaffold_60222240
TlepHiC_scaffold_60222260 takakia_lepidozioides TlepHiC_scaffold_60222260
TlepHiC_scaffold_60223320 takakia_lepidozioides TlepHiC_scaffold_60223320
TlepHiC_scaffold_60223410 takakia_lepidozioides TlepHiC_scaffold_60223410
TlepHiC_scaffold_60223540 takakia_lepidozioides TlepHiC_scaffold_60223540
TlepHiC_scaffold_60223560 takakia_lepidozioides TlepHiC_scaffold_60223560
TlepHiC_scaffold_60223700 takakia_lepidozioides TlepHiC_scaffold_60223700
TlepHiC_scaffold_60223710 takakia_lepidozioides TlepHiC_scaffold_60223710
TlepHiC_scaffold_60223720 takakia_lepidozioides TlepHiC_scaffold_60223720
TlepHiC_scaffold_60223950 takakia_lepidozioides TlepHiC_scaffold_60223950
TlepHiC_scaffold_60223970 takakia_lepidozioides TlepHiC_scaffold_60223970
TlepHiC_scaffold_60225900 takakia_lepidozioides TlepHiC_scaffold_60225900
TlepHiC_scaffold_60228260 takakia_lepidozioides TlepHiC_scaffold_60228260
TlepHiC_scaffold_60228560 takakia_lepidozioides TlepHiC_scaffold_60228560
TlepHiC_scaffold_60235360 takakia_lepidozioides TlepHiC_scaffold_60235360
TlepHiC_scaffold_60241690 takakia_lepidozioides TlepHiC_scaffold_60241690
TlepHiC_scaffold_60242050 takakia_lepidozioides TlepHiC_scaffold_60242050
TlepHiC_scaffold_60249090 takakia_lepidozioides TlepHiC_scaffold_60249090
PNH04869.1_tsocial tetrabaena_socialis PNH04869.1_tsocial