PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL78
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H351
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL317
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT2109
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR1101
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS281
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR403
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Algae (4640)
Current lineage filter: Algae. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits4640
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Chara braunii
Botryococcus braunii
Chromochloris zofingiensis
Chlamydomonas reinhardtii
Cyanophora paradoxa
Dunaliella salina
Caulerpa lentillifera
Chlamydomonas schloesseri
Chlorokybus atmophyticus
Takakia lepidozioides
Lineage Summary
Algae
4640
Module Gene List
Reset
GeneSpeciesProtein ID
PNH05873.1_tsocial tetrabaena_socialis PNH05873.1_tsocial
PNH06824.1_tsocial tetrabaena_socialis PNH06824.1_tsocial
PNH07737.1_tsocial tetrabaena_socialis PNH07737.1_tsocial
PNH07830.1_tsocial tetrabaena_socialis PNH07830.1_tsocial
PNH09370.1_tsocial tetrabaena_socialis PNH09370.1_tsocial
jgi|Ulvmu1|1355|UM011_0083.1 ulva_mutabilis jgi|Ulvmu1|1355|UM011_0083.1
jgi|Ulvmu1|3790|UM179_0004.1 ulva_mutabilis jgi|Ulvmu1|3790|UM179_0004.1
jgi|Ulvmu1|7279|UM035_0067.1 ulva_mutabilis jgi|Ulvmu1|7279|UM035_0067.1
jgi|Ulvmu1|7680|UM038_0111.1 ulva_mutabilis jgi|Ulvmu1|7680|UM038_0111.1
jgi|Ulvmu1|9114|UM005_0209.1 ulva_mutabilis jgi|Ulvmu1|9114|UM005_0209.1
jgi|Ulvmu1|9119|UM005_0214.1 ulva_mutabilis jgi|Ulvmu1|9119|UM005_0214.1
Vcarscaffold_10004110.1 volvox_carteri Vcarscaffold_10004110.1
Vcarscaffold_10008050.1 volvox_carteri Vcarscaffold_10008050.1
Vcarscaffold_150034600.1 volvox_carteri Vcarscaffold_150034600.1
Vcarscaffold_650124680.1 volvox_carteri Vcarscaffold_650124680.1
Aprocontig_KL6620790001260.1 auxenochlorella_protothecoides Aprocontig_KL6620790001260.1
Aprocontig_KL6620820002860.1 auxenochlorella_protothecoides Aprocontig_KL6620820002860.1
Aprocontig_KL6620850004550.1 auxenochlorella_protothecoides Aprocontig_KL6620850004550.1
Aprocontig_KL6620890005450.1 auxenochlorella_protothecoides Aprocontig_KL6620890005450.1
Aprocontig_KL6620890007150.1 auxenochlorella_protothecoides Aprocontig_KL6620890007150.1
Aprocontig_KL6620900008330.1 auxenochlorella_protothecoides Aprocontig_KL6620900008330.1
Aprocontig_KL6620920009190.1 auxenochlorella_protothecoides Aprocontig_KL6620920009190.1
Aprocontig_KL6621000011980.1 auxenochlorella_protothecoides Aprocontig_KL6621000011980.1
Aprocontig_KL6621000012160.1 auxenochlorella_protothecoides Aprocontig_KL6621000012160.1
Aprocontig_KL6621000012170.1 auxenochlorella_protothecoides Aprocontig_KL6621000012170.1
Aprocontig_KL6621020014150.1 auxenochlorella_protothecoides Aprocontig_KL6621020014150.1
Aprocontig_KL6621040015000.1 auxenochlorella_protothecoides Aprocontig_KL6621040015000.1
Aprocontig_KL6621040015040.1 auxenochlorella_protothecoides Aprocontig_KL6621040015040.1
Aprocontig_KL6621060016250.1 auxenochlorella_protothecoides Aprocontig_KL6621060016250.1
Aprocontig_KL6621070018140.1 auxenochlorella_protothecoides Aprocontig_KL6621070018140.1