PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL146
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H1115
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL584
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT251
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR200
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS458
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR135
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Gymnosperms (2889)
Current lineage filter: Gymnosperms. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits2889
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Ginkgo biloba
Abies alba
Gnetum montanum
Pinus taeda
Taxus chinensis
Welwitschia mirabilis
Lineage Summary
Gymnosperms
2889
Module Gene List
Reset
GeneSpeciesProtein ID
Gmon22G0008610 gnetum_montanum Gmon22G0008610
GmonSuper-Scaffold_2392:::fragment_10003010 gnetum_montanum GmonSuper-Scaffold_2392:::fragment_10003010
GmonSuper-Scaffold_2392:::fragment_10003030 gnetum_montanum GmonSuper-Scaffold_2392:::fragment_10003030
GmonSuper-Scaffold_2392:::fragment_10003040 gnetum_montanum GmonSuper-Scaffold_2392:::fragment_10003040
GmonSuper-Scaffold_2392:::fragment_10003050 gnetum_montanum GmonSuper-Scaffold_2392:::fragment_10003050
GmonSuper-Scaffold_2392:::fragment_10003060 gnetum_montanum GmonSuper-Scaffold_2392:::fragment_10003060
GmonSuper-Scaffold_2392:::fragment_4:::debris0003090 gnetum_montanum GmonSuper-Scaffold_2392:::fragment_4:::debris0003090
GmonSuper-Scaffold_2392:::fragment_50003110 gnetum_montanum GmonSuper-Scaffold_2392:::fragment_50003110
GmonSuper-Scaffold_2392:::fragment_50003130 gnetum_montanum GmonSuper-Scaffold_2392:::fragment_50003130
GmonSuper-Scaffold_2597:::fragment_10003710 gnetum_montanum GmonSuper-Scaffold_2597:::fragment_10003710
GmonSuper-Scaffold_2597:::fragment_10003760 gnetum_montanum GmonSuper-Scaffold_2597:::fragment_10003760
GmonSuper-Scaffold_2597:::fragment_10003820 gnetum_montanum GmonSuper-Scaffold_2597:::fragment_10003820
GmonSuper-Scaffold_2597:::fragment_2:::debris0003830 gnetum_montanum GmonSuper-Scaffold_2597:::fragment_2:::debris0003830
GmonSuper-Scaffold_2597:::fragment_2:::debris0003840 gnetum_montanum GmonSuper-Scaffold_2597:::fragment_2:::debris0003840
GmonSuper-Scaffold_31450005180 gnetum_montanum GmonSuper-Scaffold_31450005180
GmonSuper-Scaffold_31450005190 gnetum_montanum GmonSuper-Scaffold_31450005190
GmonSuper-Scaffold_35330006140 gnetum_montanum GmonSuper-Scaffold_35330006140
GmonSuper-Scaffold_35330006150 gnetum_montanum GmonSuper-Scaffold_35330006150
GmonSuper-Scaffold_35330006160 gnetum_montanum GmonSuper-Scaffold_35330006160
GmonSuper-Scaffold_3545:::fragment_10006200 gnetum_montanum GmonSuper-Scaffold_3545:::fragment_10006200
GmonSuper-Scaffold_3545:::fragment_10006270 gnetum_montanum GmonSuper-Scaffold_3545:::fragment_10006270
GmonSuper-Scaffold_3668:::fragment_10006450 gnetum_montanum GmonSuper-Scaffold_3668:::fragment_10006450
GmonSuper-Scaffold_37040006730 gnetum_montanum GmonSuper-Scaffold_37040006730
GmonSuper-Scaffold_3865:::fragment_30007050 gnetum_montanum GmonSuper-Scaffold_3865:::fragment_30007050
GmonSuper-Scaffold_4183:::fragment_10007450 gnetum_montanum GmonSuper-Scaffold_4183:::fragment_10007450
GmonSuper-Scaffold_455:::fragment_10008160 gnetum_montanum GmonSuper-Scaffold_455:::fragment_10008160
GmonSuper-Scaffold_493330008660 gnetum_montanum GmonSuper-Scaffold_493330008660
GmonSuper-Scaffold_8890010550 gnetum_montanum GmonSuper-Scaffold_8890010550
GmonSuper-Scaffold_933:::fragment_10010780 gnetum_montanum GmonSuper-Scaffold_933:::fragment_10010780
GmonfragScaff_scaffold_13240011390 gnetum_montanum GmonfragScaff_scaffold_13240011390