PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL146
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H1115
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL584
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT251
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR200
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS458
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR135
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Gymnosperms (2889)
Current lineage filter: Gymnosperms. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits2889
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Ginkgo biloba
Abies alba
Gnetum montanum
Pinus taeda
Taxus chinensis
Welwitschia mirabilis
Lineage Summary
Gymnosperms
2889
Module Gene List
Reset
GeneSpeciesProtein ID
GmonfragScaff_scaffold_21410012130 gnetum_montanum GmonfragScaff_scaffold_21410012130
GmonfragScaff_scaffold_21410012140 gnetum_montanum GmonfragScaff_scaffold_21410012140
GmonfragScaff_scaffold_21410012150 gnetum_montanum GmonfragScaff_scaffold_21410012150
GmonfragScaff_scaffold_21410012160 gnetum_montanum GmonfragScaff_scaffold_21410012160
GmonfragScaff_scaffold_2366_obj0012380 gnetum_montanum GmonfragScaff_scaffold_2366_obj0012380
GmonfragScaff_scaffold_2980012900 gnetum_montanum GmonfragScaff_scaffold_2980012900
GmonfragScaff_scaffold_33300013230 gnetum_montanum GmonfragScaff_scaffold_33300013230
GmonfragScaff_scaffold_33940013390 gnetum_montanum GmonfragScaff_scaffold_33940013390
GmonfragScaff_scaffold_3821_obj0013640 gnetum_montanum GmonfragScaff_scaffold_3821_obj0013640
GmonfragScaff_scaffold_4362_obj0014170 gnetum_montanum GmonfragScaff_scaffold_4362_obj0014170
GmonfragScaff_scaffold_50610014660 gnetum_montanum GmonfragScaff_scaffold_50610014660
GmonfragScaff_scaffold_53950014910 gnetum_montanum GmonfragScaff_scaffold_53950014910
Gmonoriginal_scaffold_1222230017820 gnetum_montanum Gmonoriginal_scaffold_1222230017820
Gmonoriginal_scaffold_1260440018240 gnetum_montanum Gmonoriginal_scaffold_1260440018240
Gmonoriginal_scaffold_142560018450 gnetum_montanum Gmonoriginal_scaffold_142560018450
Gmonoriginal_scaffold_258480019600 gnetum_montanum Gmonoriginal_scaffold_258480019600
Gmonoriginal_scaffold_268430019760 gnetum_montanum Gmonoriginal_scaffold_268430019760
Gmonoriginal_scaffold_334770020400 gnetum_montanum Gmonoriginal_scaffold_334770020400
Gmonoriginal_scaffold_395660021130 gnetum_montanum Gmonoriginal_scaffold_395660021130
Gmonoriginal_scaffold_491400022180 gnetum_montanum Gmonoriginal_scaffold_491400022180
Gmonoriginal_scaffold_491400022190 gnetum_montanum Gmonoriginal_scaffold_491400022190
Gmonoriginal_scaffold_568160023260 gnetum_montanum Gmonoriginal_scaffold_568160023260
Gmonoriginal_scaffold_583460023450 gnetum_montanum Gmonoriginal_scaffold_583460023450
Gmonoriginal_scaffold_586780023470 gnetum_montanum Gmonoriginal_scaffold_586780023470
Gmonoriginal_scaffold_607270023760 gnetum_montanum Gmonoriginal_scaffold_607270023760
Gmonoriginal_scaffold_675710024420 gnetum_montanum Gmonoriginal_scaffold_675710024420
Gmonoriginal_scaffold_675710024430 gnetum_montanum Gmonoriginal_scaffold_675710024430
Gmonoriginal_scaffold_751530025480 gnetum_montanum Gmonoriginal_scaffold_751530025480
Gmonoriginal_scaffold_791620025900 gnetum_montanum Gmonoriginal_scaffold_791620025900
Gmonoriginal_scaffold_813870026110 gnetum_montanum Gmonoriginal_scaffold_813870026110