Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
angelica_sinensis_AS11G01834-RA	angelica_sinensis	angelica_sinensis_AS11G01834-RA
angelica_sinensis_AS11G01835-RA	angelica_sinensis	angelica_sinensis_AS11G01835-RA
angelica_sinensis_ASUnG00386-RA	angelica_sinensis	angelica_sinensis_ASUnG00386-RA
angelica_sinensis_ASUnG00604-RA	angelica_sinensis	angelica_sinensis_ASUnG00604-RA
angelica_sinensis_ASUnG02444-RA	angelica_sinensis	angelica_sinensis_ASUnG02444-RA
angelica_sinensis_ASUnG02853-RA	angelica_sinensis	angelica_sinensis_ASUnG02853-RA
angelica_sinensis_ASUnG02857-RA	angelica_sinensis	angelica_sinensis_ASUnG02857-RA
angelica_sinensis_ASUnG03396-RA	angelica_sinensis	angelica_sinensis_ASUnG03396-RA
angelica_sinensis_ASUnG03400-RA	angelica_sinensis	angelica_sinensis_ASUnG03400-RA
angelica_sinensis_ASUnG03765-RA	angelica_sinensis	angelica_sinensis_ASUnG03765-RA
angelica_sinensis_ASUnG04169-RA	angelica_sinensis	angelica_sinensis_ASUnG04169-RA
anisodus_acutangulus_KAJ8526826.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8526826.1
anisodus_acutangulus_KAJ8526828.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8526828.1
anisodus_acutangulus_KAJ8527076.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8527076.1
anisodus_acutangulus_KAJ8527898.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8527898.1
anisodus_acutangulus_KAJ8529199.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8529199.1
anisodus_acutangulus_KAJ8529200.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8529200.1
anisodus_acutangulus_KAJ8529666.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8529666.1
anisodus_acutangulus_KAJ8529667.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8529667.1
anisodus_acutangulus_KAJ8529925.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8529925.1
anisodus_acutangulus_KAJ8530100.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8530100.1
anisodus_acutangulus_KAJ8530101.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8530101.1
anisodus_acutangulus_KAJ8530103.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8530103.1
anisodus_acutangulus_KAJ8530219.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8530219.1
anisodus_acutangulus_KAJ8530308.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8530308.1
anisodus_acutangulus_KAJ8531094.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8531094.1
anisodus_acutangulus_KAJ8531244.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8531244.1
anisodus_acutangulus_KAJ8531603.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8531603.1
anisodus_acutangulus_KAJ8532071.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8532071.1
anisodus_acutangulus_KAJ8532073.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8532073.1