Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
acer_truncatum_Atru.chr12.1336	acer_truncatum	acer_truncatum_Atru.chr12.1336
acer_truncatum_Atru.chr12.1337	acer_truncatum	acer_truncatum_Atru.chr12.1337
acer_truncatum_Atru.chr12.1357	acer_truncatum	acer_truncatum_Atru.chr12.1357
acer_truncatum_Atru.chr12.1430	acer_truncatum	acer_truncatum_Atru.chr12.1430
acer_truncatum_Atru.chr12.1431	acer_truncatum	acer_truncatum_Atru.chr12.1431
acer_truncatum_Atru.chr12.1435	acer_truncatum	acer_truncatum_Atru.chr12.1435
acer_truncatum_Atru.chr12.1446	acer_truncatum	acer_truncatum_Atru.chr12.1446
acer_truncatum_Atru.chr12.1469	acer_truncatum	acer_truncatum_Atru.chr12.1469
acer_truncatum_Atru.chr12.1752	acer_truncatum	acer_truncatum_Atru.chr12.1752
acer_truncatum_Atru.chr12.1762	acer_truncatum	acer_truncatum_Atru.chr12.1762
acer_truncatum_Atru.chr12.1825	acer_truncatum	acer_truncatum_Atru.chr12.1825
acer_truncatum_Atru.chr12.1860	acer_truncatum	acer_truncatum_Atru.chr12.1860
acer_truncatum_Atru.chr12.1866	acer_truncatum	acer_truncatum_Atru.chr12.1866
acer_truncatum_Atru.chr12.456	acer_truncatum	acer_truncatum_Atru.chr12.456
acer_truncatum_Atru.chr12.478	acer_truncatum	acer_truncatum_Atru.chr12.478
acer_truncatum_Atru.chr12.726	acer_truncatum	acer_truncatum_Atru.chr12.726
acer_truncatum_Atru.chr12.727	acer_truncatum	acer_truncatum_Atru.chr12.727
acer_truncatum_Atru.chr13.214	acer_truncatum	acer_truncatum_Atru.chr13.214
acer_truncatum_Atru.chr13.2267.2	acer_truncatum	acer_truncatum_Atru.chr13.2267.2
acer_truncatum_Atru.chr13.851	acer_truncatum	acer_truncatum_Atru.chr13.851
acer_truncatum_Atru.chr13.853	acer_truncatum	acer_truncatum_Atru.chr13.853
acer_truncatum_Atru.chr13.878	acer_truncatum	acer_truncatum_Atru.chr13.878
acer_truncatum_Atru.chr2.1566	acer_truncatum	acer_truncatum_Atru.chr2.1566
acer_truncatum_Atru.chr2.2133	acer_truncatum	acer_truncatum_Atru.chr2.2133
acer_truncatum_Atru.chr2.2134	acer_truncatum	acer_truncatum_Atru.chr2.2134
acer_truncatum_Atru.chr2.2138_Atru.chr2.2139_Atru.chr2.2141	acer_truncatum	acer_truncatum_Atru.chr2.2138_Atru.chr2.2139_Atru.chr2.2141
acer_truncatum_Atru.chr2.2140	acer_truncatum	acer_truncatum_Atru.chr2.2140
acer_truncatum_Atru.chr2.2144	acer_truncatum	acer_truncatum_Atru.chr2.2144
acer_truncatum_Atru.chr2.245	acer_truncatum	acer_truncatum_Atru.chr2.245
acer_truncatum_Atru.chr2.249	acer_truncatum	acer_truncatum_Atru.chr2.249