Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT176 SQE36 CAS940

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT3184 SMO1/SMO265 CPI131 CYP51G111 FK84 HYD135 DWF7146 DWF5174 DWF115

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET251 DWF4/CYP90B122 CPD/CYP90A121 ROT3/CYP90C11 CYP90D1 BR6OX1/CYP85A14 BR6OX2/CYP85A2

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Algae (1896)

Current lineage filter: Algae. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chromochloris zofingiensis

Penium margaritaceum

Botryococcus braunii

Chlamydomonas reinhardtii

Chlamydomonas schloesseri

Cyanophora paradoxa

Chlorokybus atmophyticus

Dunaliella salina

Takakia lepidozioides

Lineage Summary

Algae

1896

Module Gene List

Gene	Species	Protein ID
Bathy15g00040	bathycoccus_prasinos	Bathy15g00040
Bathy15g01850	bathycoccus_prasinos	Bathy15g01850
Bbrascaffold_1080007390.1	botryococcus_braunii	Bbrascaffold_1080007390.1
Bbrascaffold_1250019310.1	botryococcus_braunii	Bbrascaffold_1250019310.1
Bbrascaffold_1330023850.1	botryococcus_braunii	Bbrascaffold_1330023850.1
Bbrascaffold_1380027030.1	botryococcus_braunii	Bbrascaffold_1380027030.1
Bbrascaffold_1410030210.1	botryococcus_braunii	Bbrascaffold_1410030210.1
Bbrascaffold_1440032220.1	botryococcus_braunii	Bbrascaffold_1440032220.1
Bbrascaffold_1440032230.1	botryococcus_braunii	Bbrascaffold_1440032230.1
Bbrascaffold_145_10033100.1	botryococcus_braunii	Bbrascaffold_145_10033100.1
Bbrascaffold_145_20033740.1	botryococcus_braunii	Bbrascaffold_145_20033740.1
Bbrascaffold_150038250.1	botryococcus_braunii	Bbrascaffold_150038250.1
Bbrascaffold_1630050620.1	botryococcus_braunii	Bbrascaffold_1630050620.1
Bbrascaffold_1690056830.1	botryococcus_braunii	Bbrascaffold_1690056830.1
Bbrascaffold_1810068230.1	botryococcus_braunii	Bbrascaffold_1810068230.1
Bbrascaffold_1810068250.1	botryococcus_braunii	Bbrascaffold_1810068250.1
Bbrascaffold_1810068280.1	botryococcus_braunii	Bbrascaffold_1810068280.1
Bbrascaffold_182_20069000.1	botryococcus_braunii	Bbrascaffold_182_20069000.1
Bbrascaffold_182_20069000.2	botryococcus_braunii	Bbrascaffold_182_20069000.2
Bbrascaffold_182_20069000.3	botryococcus_braunii	Bbrascaffold_182_20069000.3
Bbrascaffold_182_30070070.1	botryococcus_braunii	Bbrascaffold_182_30070070.1
Bbrascaffold_182_30070070.2	botryococcus_braunii	Bbrascaffold_182_30070070.2
Bbrascaffold_182_30070070.3	botryococcus_braunii	Bbrascaffold_182_30070070.3
Bbrascaffold_1860073980.1	botryococcus_braunii	Bbrascaffold_1860073980.1
Bbrascaffold_1970079670.1	botryococcus_braunii	Bbrascaffold_1970079670.1
Bbrascaffold_20080140.1	botryococcus_braunii	Bbrascaffold_20080140.1
Bbrascaffold_2380097470.1	botryococcus_braunii	Bbrascaffold_2380097470.1
Bbrascaffold_2780107570.1	botryococcus_braunii	Bbrascaffold_2780107570.1
Bbrascaffold_290109980.1	botryococcus_braunii	Bbrascaffold_290109980.1
Bbrascaffold_290109990.1	botryococcus_braunii	Bbrascaffold_290109990.1