PlantSME Plant secondary metabolism enzyme database
Steroid portable pathway

Steroid portable pathway

Category：Steroid pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route
Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.
3 curated steps/modules
Sterol Scaffold Formation
01
Substrate
Farnesyl diphosphate
C15H28O7P2
C15 prenyl-OPP
Squalene synthesis, epoxidation, and cyclization
SQS/FDFT115 SQE6 CAS54
Product
Cycloartenol
C30H50O
tetracyclic sterol nucleus with cyclopropyl side
SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.
02
Substrate
Cycloartenol-series intermediates
C28-C30 sterols
tetracyclic sterol nucleus
Demethylation, reduction, and side-chain remodeling
SMT1/SMT2/SMT349 SMO1/SMO241 CPI15 CYP51G17 FK6 HYD16 DWF722 DWF53 DWF18
Product
Phytosterols
C28H48O / C29H50O
sterol nucleus-C8/C9 side chain
This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.
Brassinosteroid Branch
03
Substrate
Campesterol-like sterols
C28H48O
sterol nucleus-C8 side chain
Sterol hydroxylation/oxidation to brassinosteroids
DET216 DWF4/CYP90B17 CPD/CYP90A15 ROT3/CYP90C13 CYP90D1 BR6OX1/CYP85A1 BR6OX2/CYP85A2
Product
Brassinosteroids
C28 oxygenated lactones
polyhydroxylated steroid lactone
DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Lycophytes/Ferns (253)
Current lineage filter: Lycophytes/Ferns. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits253
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Azolla filiculoides
Isoetes taiwanensis
Selaginella moellendorffii
Salvinia cucullata
Lineage Summary
Lycophytes/Ferns
253
Module Gene List
Reset
GeneSpeciesProtein ID
ItaiItaiw_v1_scaffold_10047590.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_10047590.1
ItaiItaiw_v1_scaffold_10047600.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_10047600.1
ItaiItaiw_v1_scaffold_10052580.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_10052580.1
ItaiItaiw_v1_scaffold_10056920.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_10056920.1
ItaiItaiw_v1_scaffold_1040069650.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_1040069650.1
ItaiItaiw_v1_scaffold_1070072190.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_1070072190.1
ItaiItaiw_v1_scaffold_1120083390.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_1120083390.1
ItaiItaiw_v1_scaffold_1160085550.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_1160085550.1
ItaiItaiw_v1_scaffold_1160086260.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_1160086260.1
ItaiItaiw_v1_scaffold_120092470.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_120092470.1
ItaiItaiw_v1_scaffold_1220096470.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_1220096470.1
ItaiItaiw_v1_scaffold_1290099360.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_1290099360.1
ItaiItaiw_v1_scaffold_1300104390.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_1300104390.1
ItaiItaiw_v1_scaffold_130101850.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_130101850.1
ItaiItaiw_v1_scaffold_130104040.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_130104040.1
ItaiItaiw_v1_scaffold_1360107360.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_1360107360.1
ItaiItaiw_v1_scaffold_140110270.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_140110270.1
ItaiItaiw_v1_scaffold_140112310.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_140112310.1
ItaiItaiw_v1_scaffold_150120610.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_150120610.1
ItaiItaiw_v1_scaffold_160125540.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_160125540.1
ItaiItaiw_v1_scaffold_160129590.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_160129590.1
ItaiItaiw_v1_scaffold_170134070.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_170134070.1
ItaiItaiw_v1_scaffold_170134080.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_170134080.1
ItaiItaiw_v1_scaffold_190149220.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_190149220.1
ItaiItaiw_v1_scaffold_20153060.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_20153060.1
ItaiItaiw_v1_scaffold_20153080.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_20153080.1
ItaiItaiw_v1_scaffold_220175570.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_220175570.1
ItaiItaiw_v1_scaffold_230181570.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_230181570.1
ItaiItaiw_v1_scaffold_260199330.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_260199330.1
ItaiItaiw_v1_scaffold_290210880.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_290210880.1