PlantSME Plant secondary metabolism enzyme database
Steroid portable pathway

Steroid portable pathway

Category：Steroid pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route
Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.
3 curated steps/modules
Sterol Scaffold Formation
01
Substrate
Farnesyl diphosphate
C15H28O7P2
C15 prenyl-OPP
Squalene synthesis, epoxidation, and cyclization
SQS/FDFT115 SQE6 CAS54
Product
Cycloartenol
C30H50O
tetracyclic sterol nucleus with cyclopropyl side
SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.
02
Substrate
Cycloartenol-series intermediates
C28-C30 sterols
tetracyclic sterol nucleus
Demethylation, reduction, and side-chain remodeling
SMT1/SMT2/SMT349 SMO1/SMO241 CPI15 CYP51G17 FK6 HYD16 DWF722 DWF53 DWF18
Product
Phytosterols
C28H48O / C29H50O
sterol nucleus-C8/C9 side chain
This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.
Brassinosteroid Branch
03
Substrate
Campesterol-like sterols
C28H48O
sterol nucleus-C8 side chain
Sterol hydroxylation/oxidation to brassinosteroids
DET216 DWF4/CYP90B17 CPD/CYP90A15 ROT3/CYP90C13 CYP90D1 BR6OX1/CYP85A1 BR6OX2/CYP85A2
Product
Brassinosteroids
C28 oxygenated lactones
polyhydroxylated steroid lactone
DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Lycophytes/Ferns (253)
Current lineage filter: Lycophytes/Ferns. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits253
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Azolla filiculoides
Isoetes taiwanensis
Selaginella moellendorffii
Salvinia cucullata
Lineage Summary
Lycophytes/Ferns
253
Module Gene List
Reset
GeneSpeciesProtein ID
ItaiItaiw_v1_scaffold_300225010.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_300225010.1
ItaiItaiw_v1_scaffold_30222510.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_30222510.1
ItaiItaiw_v1_scaffold_380255610.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_380255610.1
ItaiItaiw_v1_scaffold_400269760.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_400269760.1
ItaiItaiw_v1_scaffold_400269820.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_400269820.1
ItaiItaiw_v1_scaffold_40261940.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_40261940.1
ItaiItaiw_v1_scaffold_40265290.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_40265290.1
ItaiItaiw_v1_scaffold_40265780.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_40265780.1
ItaiItaiw_v1_scaffold_40267870.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_40267870.1
ItaiItaiw_v1_scaffold_40268650.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_40268650.1
ItaiItaiw_v1_scaffold_430279840.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_430279840.1
ItaiItaiw_v1_scaffold_460288980.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_460288980.1
ItaiItaiw_v1_scaffold_460289010.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_460289010.1
ItaiItaiw_v1_scaffold_480297190.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_480297190.1
ItaiItaiw_v1_scaffold_500310760.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_500310760.1
ItaiItaiw_v1_scaffold_50308480.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_50308480.1
ItaiItaiw_v1_scaffold_540321340.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_540321340.1
ItaiItaiw_v1_scaffold_590333400.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_590333400.1
ItaiItaiw_v1_scaffold_620344290.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_620344290.1
ItaiItaiw_v1_scaffold_620344950.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_620344950.1
ItaiItaiw_v1_scaffold_650352160.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_650352160.1
ItaiItaiw_v1_scaffold_680357390.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_680357390.1
ItaiItaiw_v1_scaffold_680357420.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_680357420.1
ItaiItaiw_v1_scaffold_690359080.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_690359080.1
ItaiItaiw_v1_scaffold_70364970.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_70364970.1
ItaiItaiw_v1_scaffold_720369620.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_720369620.1
ItaiItaiw_v1_scaffold_720369630.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_720369630.1
ItaiItaiw_v1_scaffold_720369730.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_720369730.1
ItaiItaiw_v1_scaffold_730373000.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_730373000.1
ItaiItaiw_v1_scaffold_770376810.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_770376810.1