PlantSME Plant secondary metabolism enzyme database
Steroid portable pathway

Steroid portable pathway

Category：Steroid pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route
Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.
3 curated steps/modules
Sterol Scaffold Formation
01
Substrate
Farnesyl diphosphate
C15H28O7P2
C15 prenyl-OPP
Squalene synthesis, epoxidation, and cyclization
SQS/FDFT115 SQE6 CAS54
Product
Cycloartenol
C30H50O
tetracyclic sterol nucleus with cyclopropyl side
SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.
02
Substrate
Cycloartenol-series intermediates
C28-C30 sterols
tetracyclic sterol nucleus
Demethylation, reduction, and side-chain remodeling
SMT1/SMT2/SMT349 SMO1/SMO241 CPI15 CYP51G17 FK6 HYD16 DWF722 DWF53 DWF18
Product
Phytosterols
C28H48O / C29H50O
sterol nucleus-C8/C9 side chain
This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.
Brassinosteroid Branch
03
Substrate
Campesterol-like sterols
C28H48O
sterol nucleus-C8 side chain
Sterol hydroxylation/oxidation to brassinosteroids
DET216 DWF4/CYP90B17 CPD/CYP90A15 ROT3/CYP90C13 CYP90D1 BR6OX1/CYP85A1 BR6OX2/CYP85A2
Product
Brassinosteroids
C28 oxygenated lactones
polyhydroxylated steroid lactone
DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Lycophytes/Ferns (253)
Current lineage filter: Lycophytes/Ferns. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits253
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Azolla filiculoides
Isoetes taiwanensis
Selaginella moellendorffii
Salvinia cucullata
Lineage Summary
Lycophytes/Ferns
253
Module Gene List
Reset
GeneSpeciesProtein ID
ItaiItaiw_v1_scaffold_790379120.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_790379120.1
ItaiItaiw_v1_scaffold_790379130.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_790379130.1
ItaiItaiw_v1_scaffold_860392310.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_860392310.1
ItaiItaiw_v1_scaffold_90397040.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_90397040.1
ItaiItaiw_v1_scaffold_910403490.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_910403490.1
ItaiItaiw_v1_scaffold_910403570.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_910403570.1
ItaiItaiw_v1_scaffold_920404870.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_920404870.1
ItaiItaiw_v1_scaffold_920405220.1 isoetes_taiwanensis ItaiItaiw_v1_scaffold_920405220.1
ScucSacu_v1.1_s00010001560 salvinia_cucullata ScucSacu_v1.1_s00010001560
ScucSacu_v1.1_s00030010650 salvinia_cucullata ScucSacu_v1.1_s00030010650
ScucSacu_v1.1_s00040014560 salvinia_cucullata ScucSacu_v1.1_s00040014560
ScucSacu_v1.1_s00050017720 salvinia_cucullata ScucSacu_v1.1_s00050017720
ScucSacu_v1.1_s00060018890 salvinia_cucullata ScucSacu_v1.1_s00060018890
ScucSacu_v1.1_s00080024470 salvinia_cucullata ScucSacu_v1.1_s00080024470
ScucSacu_v1.1_s00140038370 salvinia_cucullata ScucSacu_v1.1_s00140038370
ScucSacu_v1.1_s00210053620 salvinia_cucullata ScucSacu_v1.1_s00210053620
ScucSacu_v1.1_s00220055850 salvinia_cucullata ScucSacu_v1.1_s00220055850
ScucSacu_v1.1_s00320070430 salvinia_cucullata ScucSacu_v1.1_s00320070430
ScucSacu_v1.1_s00320070860 salvinia_cucullata ScucSacu_v1.1_s00320070860
ScucSacu_v1.1_s00370077660 salvinia_cucullata ScucSacu_v1.1_s00370077660
ScucSacu_v1.1_s00610102990 salvinia_cucullata ScucSacu_v1.1_s00610102990
ScucSacu_v1.1_s00630105380 salvinia_cucullata ScucSacu_v1.1_s00630105380
ScucSacu_v1.1_s00660109010 salvinia_cucullata ScucSacu_v1.1_s00660109010
ScucSacu_v1.1_s00680110410 salvinia_cucullata ScucSacu_v1.1_s00680110410
ScucSacu_v1.1_s00920129120 salvinia_cucullata ScucSacu_v1.1_s00920129120
ScucSacu_v1.1_s00950131450 salvinia_cucullata ScucSacu_v1.1_s00950131450
ScucSacu_v1.1_s01020136650 salvinia_cucullata ScucSacu_v1.1_s01020136650
ScucSacu_v1.1_s01140144050 salvinia_cucullata ScucSacu_v1.1_s01140144050
ScucSacu_v1.1_s01230148560 salvinia_cucullata ScucSacu_v1.1_s01230148560
ScucSacu_v1.1_s01280151340 salvinia_cucullata ScucSacu_v1.1_s01280151340