Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
ACeri29G0012680	actinidia_eriantha	ACeri29G0012680
ACeri29G0012920	actinidia_eriantha	ACeri29G0012920
ACeriChr000003880	actinidia_eriantha	ACeriChr000003880
actinidia_hemsleyana_GWHPCBQA000445	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA000445
actinidia_hemsleyana_GWHPCBQA001134	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA001134
actinidia_hemsleyana_GWHPCBQA001135	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA001135
actinidia_hemsleyana_GWHPCBQA001136	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA001136
actinidia_hemsleyana_GWHPCBQA002166	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA002166
actinidia_hemsleyana_GWHPCBQA002843	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA002843
actinidia_hemsleyana_GWHPCBQA003659	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA003659
actinidia_hemsleyana_GWHPCBQA004639	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA004639
actinidia_hemsleyana_GWHPCBQA004857	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA004857
actinidia_hemsleyana_GWHPCBQA004858	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA004858
actinidia_hemsleyana_GWHPCBQA005096	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA005096
actinidia_hemsleyana_GWHPCBQA005416	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA005416
actinidia_hemsleyana_GWHPCBQA006155	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA006155
actinidia_hemsleyana_GWHPCBQA006975	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA006975
actinidia_hemsleyana_GWHPCBQA007797	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA007797
actinidia_hemsleyana_GWHPCBQA008663	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA008663
actinidia_hemsleyana_GWHPCBQA008722	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA008722
actinidia_hemsleyana_GWHPCBQA008723	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA008723
actinidia_hemsleyana_GWHPCBQA008724	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA008724
actinidia_hemsleyana_GWHPCBQA009803	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA009803
actinidia_hemsleyana_GWHPCBQA009994	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA009994
actinidia_hemsleyana_GWHPCBQA010164	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA010164
actinidia_hemsleyana_GWHPCBQA010597	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA010597
actinidia_hemsleyana_GWHPCBQA010733	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA010733
actinidia_hemsleyana_GWHPCBQA011422	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA011422
actinidia_hemsleyana_GWHPCBQA012421	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA012421
actinidia_hemsleyana_GWHPCBQA012802	actinidia_hemsleyana	actinidia_hemsleyana_GWHPCBQA012802