Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
actinidia_zhejiangensis_GWHPCBQB087027	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB087027
actinidia_zhejiangensis_GWHPCBQB087072	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB087072
actinidia_zhejiangensis_GWHPCBQB088658	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB088658
actinidia_zhejiangensis_GWHPCBQB089013	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB089013
actinidia_zhejiangensis_GWHPCBQB089428	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB089428
actinidia_zhejiangensis_GWHPCBQB089560	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB089560
actinidia_zhejiangensis_GWHPCBQB089561	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB089561
actinidia_zhejiangensis_GWHPCBQB091220	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB091220
actinidia_zhejiangensis_GWHPCBQB092454	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB092454
actinidia_zhejiangensis_GWHPCBQB094035	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB094035
actinidia_zhejiangensis_GWHPCBQB094152	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB094152
actinidia_zhejiangensis_GWHPCBQB094153	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB094153
actinidia_zhejiangensis_GWHPCBQB094933	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB094933
actinidia_zhejiangensis_GWHPCBQB095409	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB095409
actinidia_zhejiangensis_GWHPCBQB095676	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB095676
actinidia_zhejiangensis_GWHPCBQB096516	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB096516
actinidia_zhejiangensis_GWHPCBQB096669	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB096669
actinidia_zhejiangensis_GWHPCBQB096674	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB096674
actinidia_zhejiangensis_GWHPCBQB096675	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB096675
actinidia_zhejiangensis_GWHPCBQB096676	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB096676
actinidia_zhejiangensis_GWHPCBQB096677	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB096677
actinidia_zhejiangensis_GWHPCBQB096679	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB096679
actinidia_zhejiangensis_GWHPCBQB096680	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB096680
actinidia_zhejiangensis_GWHPCBQB096684	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB096684
actinidia_zhejiangensis_GWHPCBQB096686	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB096686
actinidia_zhejiangensis_GWHPCBQB096791	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB096791
actinidia_zhejiangensis_GWHPCBQB096792	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB096792
actinidia_zhejiangensis_GWHPCBQB097136	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB097136
actinidia_zhejiangensis_GWHPCBQB098015	actinidia_zhejiangensis	actinidia_zhejiangensis_GWHPCBQB098015
Acor01G0003950.1	aegiceras_corniculatum	Acor01G0003950.1