Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT1638 SQE185 CAS2570

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT31757 SMO1/SMO21119 CPI1170 CYP51G1313 FK164 HYD1184 DWF71136 DWF5419 DWF1227

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET2416 DWF4/CYP90B1314 CPD/CYP90A1201 ROT3/CYP90C173 CYP90D11 BR6OX1/CYP85A131 BR6OX2/CYP85A27

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Bryophytes (9925)

Current lineage filter: Bryophytes. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Anthoceros agrestis Oxford

Funaria hygrometrica

Buxbaumia aphylla

Anthoceros punctatus

Calliergon cordifolium

Archidium alternifolium

Lineage Summary

Module Gene List

Gene	Species	Protein ID
Arupctg000889_np121212120078570	andreaea_rupestris	Arupctg000889_np121212120078570
Arupctg000906_np121212120083910	andreaea_rupestris	Arupctg000906_np121212120083910
Arupctg000906_np121212120084680	andreaea_rupestris	Arupctg000906_np121212120084680
Arupctg000907_np121212120086400	andreaea_rupestris	Arupctg000907_np121212120086400
Arupctg000938_np121212120090330	andreaea_rupestris	Arupctg000938_np121212120090330
Arupctg000951_np121212120092500	andreaea_rupestris	Arupctg000951_np121212120092500
Arupctg001099_np121212120111110	andreaea_rupestris	Arupctg001099_np121212120111110
Arupctg001109_np121212120112720	andreaea_rupestris	Arupctg001109_np121212120112720
Arupctg001143_np121212120117740	andreaea_rupestris	Arupctg001143_np121212120117740
Arupctg001144_np121212120117920	andreaea_rupestris	Arupctg001144_np121212120117920
Arupctg001178_np121212120122110	andreaea_rupestris	Arupctg001178_np121212120122110
Arupctg001197_np121212120123490	andreaea_rupestris	Arupctg001197_np121212120123490
Arupctg001225_np121212120125610	andreaea_rupestris	Arupctg001225_np121212120125610
Arupctg001285_np121212120136160	andreaea_rupestris	Arupctg001285_np121212120136160
Arupctg001298_np121212120137550	andreaea_rupestris	Arupctg001298_np121212120137550
Arupctg001298_np121212120138700	andreaea_rupestris	Arupctg001298_np121212120138700
Arupctg001306_np121212120140030	andreaea_rupestris	Arupctg001306_np121212120140030
Arupctg001306_np121212120142100	andreaea_rupestris	Arupctg001306_np121212120142100
Arupctg001306_np121212120142140	andreaea_rupestris	Arupctg001306_np121212120142140
Arupctg001362_np121212120152230	andreaea_rupestris	Arupctg001362_np121212120152230
Arupctg001436_np121212120161490	andreaea_rupestris	Arupctg001436_np121212120161490
Arupctg001436_np121212120161540	andreaea_rupestris	Arupctg001436_np121212120161540
Arupctg001450_np121212120164390	andreaea_rupestris	Arupctg001450_np121212120164390
Arupctg001459_np121212120167930	andreaea_rupestris	Arupctg001459_np121212120167930
Arupctg001460_np121212120168380	andreaea_rupestris	Arupctg001460_np121212120168380
Arupctg001483_np121212120170830	andreaea_rupestris	Arupctg001483_np121212120170830
Arupctg001483_np121212120171100	andreaea_rupestris	Arupctg001483_np121212120171100
Arupctg001490_np121212120173760	andreaea_rupestris	Arupctg001490_np121212120173760
Arupctg001519_np121212120176690	andreaea_rupestris	Arupctg001519_np121212120176690
Arupctg001539_np121212120180060	andreaea_rupestris	Arupctg001539_np121212120180060