Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
AaraAA_scaffold34240175490	aethionema_arabicum	AaraAA_scaffold34240175490
AaraAA_scaffold34280176370	aethionema_arabicum	AaraAA_scaffold34280176370
AaraAA_scaffold34770177190	aethionema_arabicum	AaraAA_scaffold34770177190
AaraAA_scaffold34830178440	aethionema_arabicum	AaraAA_scaffold34830178440
AaraAA_scaffold35930186760	aethionema_arabicum	AaraAA_scaffold35930186760
AaraAA_scaffold35930186830	aethionema_arabicum	AaraAA_scaffold35930186830
AaraAA_scaffold36760191530	aethionema_arabicum	AaraAA_scaffold36760191530
AaraAA_scaffold36760191540	aethionema_arabicum	AaraAA_scaffold36760191540
AaraAA_scaffold39370201980	aethionema_arabicum	AaraAA_scaffold39370201980
AaraAA_scaffold39530203410	aethionema_arabicum	AaraAA_scaffold39530203410
AaraAA_scaffold41010208530	aethionema_arabicum	AaraAA_scaffold41010208530
AaraAA_scaffold41300210060	aethionema_arabicum	AaraAA_scaffold41300210060
AaraAA_scaffold41670213450	aethionema_arabicum	AaraAA_scaffold41670213450
AaraAA_scaffold44290227150	aethionema_arabicum	AaraAA_scaffold44290227150
AaraAA_scaffold45750233310	aethionema_arabicum	AaraAA_scaffold45750233310
AaraAA_scaffold45830233500	aethionema_arabicum	AaraAA_scaffold45830233500
AaraAA_scaffold46020234070	aethionema_arabicum	AaraAA_scaffold46020234070
AaraAA_scaffold46020234080	aethionema_arabicum	AaraAA_scaffold46020234080
AaraAA_scaffold47100237700	aethionema_arabicum	AaraAA_scaffold47100237700
AaraAA_scaffold48910243790	aethionema_arabicum	AaraAA_scaffold48910243790
AaraAA_scaffold48910243800	aethionema_arabicum	AaraAA_scaffold48910243800
AaraAA_scaffold490244100	aethionema_arabicum	AaraAA_scaffold490244100
AaraAA_scaffold50570255190	aethionema_arabicum	AaraAA_scaffold50570255190
AaraAA_scaffold50570255200	aethionema_arabicum	AaraAA_scaffold50570255200
AaraAA_scaffold50570255210	aethionema_arabicum	AaraAA_scaffold50570255210
AaraAA_scaffold50570255240	aethionema_arabicum	AaraAA_scaffold50570255240
AaraAA_scaffold50570255250	aethionema_arabicum	AaraAA_scaffold50570255250
AaraAA_scaffold5170261560	aethionema_arabicum	AaraAA_scaffold5170261560
AaraAA_scaffold52400265760	aethionema_arabicum	AaraAA_scaffold52400265760
AaraAA_scaffold52790268430	aethionema_arabicum	AaraAA_scaffold52790268430