Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
Agluscaffold920_cov1060419200	alnus_glutinosa	Agluscaffold920_cov1060419200
alnus_rubra_ALNRU00000647-RA	alnus_rubra	alnus_rubra_ALNRU00000647-RA
alnus_rubra_ALNRU00001976-RA	alnus_rubra	alnus_rubra_ALNRU00001976-RA
alnus_rubra_ALNRU00002016-RA	alnus_rubra	alnus_rubra_ALNRU00002016-RA
alnus_rubra_ALNRU00003585-RA	alnus_rubra	alnus_rubra_ALNRU00003585-RA
alnus_rubra_ALNRU00003592-RA	alnus_rubra	alnus_rubra_ALNRU00003592-RA
alnus_rubra_ALNRU00005675-RA	alnus_rubra	alnus_rubra_ALNRU00005675-RA
alnus_rubra_ALNRU00005679-RA	alnus_rubra	alnus_rubra_ALNRU00005679-RA
alnus_rubra_ALNRU00005687-RA	alnus_rubra	alnus_rubra_ALNRU00005687-RA
alnus_rubra_ALNRU00005709-RA	alnus_rubra	alnus_rubra_ALNRU00005709-RA
alnus_rubra_ALNRU00005718-RA	alnus_rubra	alnus_rubra_ALNRU00005718-RA
alnus_rubra_ALNRU00005719-RA	alnus_rubra	alnus_rubra_ALNRU00005719-RA
alnus_rubra_ALNRU00005734-RA	alnus_rubra	alnus_rubra_ALNRU00005734-RA
alnus_rubra_ALNRU00005735-RA	alnus_rubra	alnus_rubra_ALNRU00005735-RA
alnus_rubra_ALNRU00005737-RA	alnus_rubra	alnus_rubra_ALNRU00005737-RA
alnus_rubra_ALNRU00005808-RA	alnus_rubra	alnus_rubra_ALNRU00005808-RA
alnus_rubra_ALNRU00005972-RA	alnus_rubra	alnus_rubra_ALNRU00005972-RA
alnus_rubra_ALNRU00007837-RA	alnus_rubra	alnus_rubra_ALNRU00007837-RA
alnus_rubra_ALNRU00007907-RA	alnus_rubra	alnus_rubra_ALNRU00007907-RA
alnus_rubra_ALNRU00009646-RA	alnus_rubra	alnus_rubra_ALNRU00009646-RA
alnus_rubra_ALNRU00009655-RA	alnus_rubra	alnus_rubra_ALNRU00009655-RA
alnus_rubra_ALNRU00010129-RA	alnus_rubra	alnus_rubra_ALNRU00010129-RA
alnus_rubra_ALNRU00010204-RA	alnus_rubra	alnus_rubra_ALNRU00010204-RA
alnus_rubra_ALNRU00010208-RA	alnus_rubra	alnus_rubra_ALNRU00010208-RA
alnus_rubra_ALNRU00010214-RA	alnus_rubra	alnus_rubra_ALNRU00010214-RA
alnus_rubra_ALNRU00011109-RA	alnus_rubra	alnus_rubra_ALNRU00011109-RA
alnus_rubra_ALNRU00012129-RA	alnus_rubra	alnus_rubra_ALNRU00012129-RA
alnus_rubra_ALNRU00012147-RA	alnus_rubra	alnus_rubra_ALNRU00012147-RA
alnus_rubra_ALNRU00012149-RA	alnus_rubra	alnus_rubra_ALNRU00012149-RA
alnus_rubra_ALNRU00012151-RA	alnus_rubra	alnus_rubra_ALNRU00012151-RA