Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT1915 SQE331 CAS8601

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT38083 SMO1/SMO22312 CPI1249 CYP51G11047 FK217 HYD1371 DWF7910 DWF5109 DWF1377

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET2476 DWF4/CYP90B1527 CPD/CYP90A1700 ROT3/CYP90C151 CYP90D124 BR6OX1/CYP85A128 BR6OX2/CYP85A29

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Monocots (25337)

Current lineage filter: Monocots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Cenchrus fungigraminus

Daemonorops jenkinsiana

Lineage Summary

Module Gene List

Gene	Species	Protein ID
AVESA.00010b.r1.5CG0897150.1	avena_sativa	AVESA.00010b.r1.5CG0897150.1
AVESA.00010b.r1.5DG0937980.1	avena_sativa	AVESA.00010b.r1.5DG0937980.1
AVESA.00010b.r1.5DG0941640.2	avena_sativa	AVESA.00010b.r1.5DG0941640.2
AVESA.00010b.r1.5DG0941660.1	avena_sativa	AVESA.00010b.r1.5DG0941660.1
AVESA.00010b.r1.5DG0950100.2	avena_sativa	AVESA.00010b.r1.5DG0950100.2
AVESA.00010b.r1.5DG0953530.2	avena_sativa	AVESA.00010b.r1.5DG0953530.2
AVESA.00010b.r1.5DG0961140.1	avena_sativa	AVESA.00010b.r1.5DG0961140.1
AVESA.00010b.r1.5DG0961150.1	avena_sativa	AVESA.00010b.r1.5DG0961150.1
AVESA.00010b.r1.5DG0961170.1	avena_sativa	AVESA.00010b.r1.5DG0961170.1
AVESA.00010b.r1.5DG0961190.1	avena_sativa	AVESA.00010b.r1.5DG0961190.1
AVESA.00010b.r1.5DG0961200.1	avena_sativa	AVESA.00010b.r1.5DG0961200.1
AVESA.00010b.r1.5DG0961210.1	avena_sativa	AVESA.00010b.r1.5DG0961210.1
AVESA.00010b.r1.5DG0970150.1	avena_sativa	AVESA.00010b.r1.5DG0970150.1
AVESA.00010b.r1.5DG0970160.1	avena_sativa	AVESA.00010b.r1.5DG0970160.1
AVESA.00010b.r1.5DG0972240.1	avena_sativa	AVESA.00010b.r1.5DG0972240.1
AVESA.00010b.r1.5DG0994300.1	avena_sativa	AVESA.00010b.r1.5DG0994300.1
AVESA.00010b.r1.5DG0994420.1	avena_sativa	AVESA.00010b.r1.5DG0994420.1
AVESA.00010b.r1.5DG0994550.1	avena_sativa	AVESA.00010b.r1.5DG0994550.1
AVESA.00010b.r1.5DG0995960.1	avena_sativa	AVESA.00010b.r1.5DG0995960.1
AVESA.00010b.r1.5DG0996930.1	avena_sativa	AVESA.00010b.r1.5DG0996930.1
AVESA.00010b.r1.5DG0997390.1	avena_sativa	AVESA.00010b.r1.5DG0997390.1
AVESA.00010b.r1.5DG0997400.1	avena_sativa	AVESA.00010b.r1.5DG0997400.1
AVESA.00010b.r1.6AG1015430.1	avena_sativa	AVESA.00010b.r1.6AG1015430.1
AVESA.00010b.r1.6AG1026990.1	avena_sativa	AVESA.00010b.r1.6AG1026990.1
AVESA.00010b.r1.6AG1034390.1	avena_sativa	AVESA.00010b.r1.6AG1034390.1
AVESA.00010b.r1.6AG1045120.1	avena_sativa	AVESA.00010b.r1.6AG1045120.1
AVESA.00010b.r1.6AG1052490.1	avena_sativa	AVESA.00010b.r1.6AG1052490.1
AVESA.00010b.r1.6AG1056560.2	avena_sativa	AVESA.00010b.r1.6AG1056560.2
AVESA.00010b.r1.6AG1060670.1	avena_sativa	AVESA.00010b.r1.6AG1060670.1
AVESA.00010b.r1.6AG1060680.1	avena_sativa	AVESA.00010b.r1.6AG1060680.1