PlantSME Plant secondary metabolism enzyme database
Phenylpropanoid portable pathway

Phenylpropanoid portable pathway

Category：Phenylpropanoid pathway

Phenylpropanoid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Phenylpropanoid Reaction Route
Entry backbone to monolignol/lignin branches. Substrates, products, and condensed structural formulae show representative conversions; resolved reactions are shown as single enzymes, whereas multi-enzyme branches are shown as curated modules. Member counts come from public annotations.
6 curated steps/modules
Entry Backbone And Lignin Direction
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination to form the phenylpropene acid scaffold
PAL1910
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL commits the amino-acid substrate to phenylpropanoid metabolism.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Para-hydroxylation of the aromatic ring
C4H401
Product
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A introduces the 4-hydroxyl group for downstream CoA activation.
03
Substrate
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation and activation
4CL3434
Product
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL converts the free acid into a thioester used by condensation, acyltransfer, and reduction reactions.
04
Substrate
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Hydroxylation, acyl transfer, and methylation
HCT1920 C3'H/CYP98A1929 CSE2414 CCoAOMT382
Product
Feruloyl-CoA-type intermediates
C31H40N7O19P3S
3-MeO-4-HO-C6H3-CH=CH-C(=O)-SCoA
This segment remodels the p-coumaroyl scaffold into caffeoyl/feruloyl-type intermediates.
05
Substrate
Hydroxycinnamoyl-CoA
C30-31 CoA thioesters
Ar-CH=CH-C(=O)-SCoA
Reduction and S/G monolignol formation
CCR2707 CAD2978 F5H/CYP84A171 COMT1825
Product
Coniferyl/sinapyl alcohol
C10H12O3 / C11H14O4
Ar-CH=CH-CH2OH
CCR/CAD and related steps route CoA thioesters toward monolignol monomers.
06
Substrate
Monolignols
C9-C11 phenylpropanoids
Ar-CH=CH-CH2OH
Oxidative coupling and polymerization
LAC3730 POD14559
Product
Lignin polymer
(C9 unit)n
[Ar-C3]n ether/C-C polymer
LAC/POD oxidatively couple monolignols into lignin polymers.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Bryophytes (38360)
Current lineage filter: Bryophytes. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits38360
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Bryum knowltonii
Anthoceros agrestis Oxford
Anthoceros punctatus
Buxbaumia aphylla
Calliergon cordifolium
Archidium alternifolium
Funaria hygrometrica
Andreaea rupestris
Acrobolbus urvilleanus
Bryoxiphium norvegicum
Lineage Summary
Bryophytes
38360
Module Gene List
Reset
GeneSpeciesProtein ID
Arupctg000933_np121212120089810 andreaea_rupestris Arupctg000933_np121212120089810
Arupctg000933_np121212120090110 andreaea_rupestris Arupctg000933_np121212120090110
Arupctg000944_np121212120090650 andreaea_rupestris Arupctg000944_np121212120090650
Arupctg000946_np121212120091230 andreaea_rupestris Arupctg000946_np121212120091230
Arupctg000963_np121212120093860 andreaea_rupestris Arupctg000963_np121212120093860
Arupctg000984_np121212120096400 andreaea_rupestris Arupctg000984_np121212120096400
Arupctg000984_np121212120096940 andreaea_rupestris Arupctg000984_np121212120096940
Arupctg000984_np121212120097200 andreaea_rupestris Arupctg000984_np121212120097200
Arupctg000990_np121212120097950 andreaea_rupestris Arupctg000990_np121212120097950
Arupctg000991_np121212120098280 andreaea_rupestris Arupctg000991_np121212120098280
Arupctg001004_np121212120099030 andreaea_rupestris Arupctg001004_np121212120099030
Arupctg001026_np121212120102320 andreaea_rupestris Arupctg001026_np121212120102320
Arupctg001031_np121212120102780 andreaea_rupestris Arupctg001031_np121212120102780
Arupctg001031_np121212120102790 andreaea_rupestris Arupctg001031_np121212120102790
Arupctg001061_np121212120106550 andreaea_rupestris Arupctg001061_np121212120106550
Arupctg001061_np121212120106650 andreaea_rupestris Arupctg001061_np121212120106650
Arupctg001066_np121212120107910 andreaea_rupestris Arupctg001066_np121212120107910
Arupctg001074_np121212120108500 andreaea_rupestris Arupctg001074_np121212120108500
Arupctg001074_np121212120108530 andreaea_rupestris Arupctg001074_np121212120108530
Arupctg001074_np121212120108540 andreaea_rupestris Arupctg001074_np121212120108540
Arupctg001105_np121212120111550 andreaea_rupestris Arupctg001105_np121212120111550
Arupctg001105_np121212120111660 andreaea_rupestris Arupctg001105_np121212120111660
Arupctg001105_np121212120111760 andreaea_rupestris Arupctg001105_np121212120111760
Arupctg001110_np121212120113200 andreaea_rupestris Arupctg001110_np121212120113200
Arupctg001110_np121212120113840 andreaea_rupestris Arupctg001110_np121212120113840
Arupctg001112_np121212120114690 andreaea_rupestris Arupctg001112_np121212120114690
Arupctg001142_np121212120115910 andreaea_rupestris Arupctg001142_np121212120115910
Arupctg001142_np121212120115980 andreaea_rupestris Arupctg001142_np121212120115980
Arupctg001142_np121212120117500 andreaea_rupestris Arupctg001142_np121212120117500
Arupctg001147_np121212120118360 andreaea_rupestris Arupctg001147_np121212120118360