PlantSME Plant secondary metabolism enzyme database
Phenylpropanoid portable pathway

Phenylpropanoid portable pathway

Category：Phenylpropanoid pathway

Phenylpropanoid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Phenylpropanoid Reaction Route
Entry backbone to monolignol/lignin branches. Substrates, products, and condensed structural formulae show representative conversions; resolved reactions are shown as single enzymes, whereas multi-enzyme branches are shown as curated modules. Member counts come from public annotations.
6 curated steps/modules
Entry Backbone And Lignin Direction
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination to form the phenylpropene acid scaffold
PAL1910
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL commits the amino-acid substrate to phenylpropanoid metabolism.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Para-hydroxylation of the aromatic ring
C4H401
Product
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A introduces the 4-hydroxyl group for downstream CoA activation.
03
Substrate
p-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation and activation
4CL3434
Product
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL converts the free acid into a thioester used by condensation, acyltransfer, and reduction reactions.
04
Substrate
p-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Hydroxylation, acyl transfer, and methylation
HCT1920 C3'H/CYP98A1929 CSE2414 CCoAOMT382
Product
Feruloyl-CoA-type intermediates
C31H40N7O19P3S
3-MeO-4-HO-C6H3-CH=CH-C(=O)-SCoA
This segment remodels the p-coumaroyl scaffold into caffeoyl/feruloyl-type intermediates.
05
Substrate
Hydroxycinnamoyl-CoA
C30-31 CoA thioesters
Ar-CH=CH-C(=O)-SCoA
Reduction and S/G monolignol formation
CCR2707 CAD2978 F5H/CYP84A171 COMT1825
Product
Coniferyl/sinapyl alcohol
C10H12O3 / C11H14O4
Ar-CH=CH-CH2OH
CCR/CAD and related steps route CoA thioesters toward monolignol monomers.
06
Substrate
Monolignols
C9-C11 phenylpropanoids
Ar-CH=CH-CH2OH
Oxidative coupling and polymerization
LAC3730 POD14559
Product
Lignin polymer
(C9 unit)n
[Ar-C3]n ether/C-C polymer
LAC/POD oxidatively couple monolignols into lignin polymers.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Bryophytes (38360)
Current lineage filter: Bryophytes. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits38360
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits0
Species Distribution
Bryum knowltonii
Anthoceros agrestis Oxford
Anthoceros punctatus
Buxbaumia aphylla
Calliergon cordifolium
Archidium alternifolium
Funaria hygrometrica
Andreaea rupestris
Acrobolbus urvilleanus
Bryoxiphium norvegicum
Lineage Summary
Bryophytes
38360
Module Gene List
Reset
GeneSpeciesProtein ID
Arupctg001314_np121212120143490 andreaea_rupestris Arupctg001314_np121212120143490
Arupctg001314_np121212120143500 andreaea_rupestris Arupctg001314_np121212120143500
Arupctg001314_np121212120144290 andreaea_rupestris Arupctg001314_np121212120144290
Arupctg001314_np121212120144310 andreaea_rupestris Arupctg001314_np121212120144310
Arupctg001314_np121212120144320 andreaea_rupestris Arupctg001314_np121212120144320
Arupctg001330_np121212120145800 andreaea_rupestris Arupctg001330_np121212120145800
Arupctg001336_np121212120145980 andreaea_rupestris Arupctg001336_np121212120145980
Arupctg001351_np121212120148740 andreaea_rupestris Arupctg001351_np121212120148740
Arupctg001353_np121212120149660 andreaea_rupestris Arupctg001353_np121212120149660
Arupctg001355_np121212120150550 andreaea_rupestris Arupctg001355_np121212120150550
Arupctg001355_np121212120150560 andreaea_rupestris Arupctg001355_np121212120150560
Arupctg001355_np121212120150570 andreaea_rupestris Arupctg001355_np121212120150570
Arupctg001359_np121212120151810 andreaea_rupestris Arupctg001359_np121212120151810
Arupctg001359_np121212120151820 andreaea_rupestris Arupctg001359_np121212120151820
Arupctg001364_np121212120152520 andreaea_rupestris Arupctg001364_np121212120152520
Arupctg001409_np121212120156050 andreaea_rupestris Arupctg001409_np121212120156050
Arupctg001409_np121212120156250 andreaea_rupestris Arupctg001409_np121212120156250
Arupctg001417_np121212120158580 andreaea_rupestris Arupctg001417_np121212120158580
Arupctg001417_np121212120159050 andreaea_rupestris Arupctg001417_np121212120159050
Arupctg001417_np121212120159060 andreaea_rupestris Arupctg001417_np121212120159060
Arupctg001420_np121212120160310 andreaea_rupestris Arupctg001420_np121212120160310
Arupctg001422_np121212120161010 andreaea_rupestris Arupctg001422_np121212120161010
Arupctg001443_np121212120162510 andreaea_rupestris Arupctg001443_np121212120162510
Arupctg001450_np121212120164550 andreaea_rupestris Arupctg001450_np121212120164550
Arupctg001455_np121212120166990 andreaea_rupestris Arupctg001455_np121212120166990
Arupctg001468_np121212120169040 andreaea_rupestris Arupctg001468_np121212120169040
Arupctg001476_np121212120169670 andreaea_rupestris Arupctg001476_np121212120169670
Arupctg001485_np121212120171220 andreaea_rupestris Arupctg001485_np121212120171220
Arupctg001489_np121212120172350 andreaea_rupestris Arupctg001489_np121212120172350
Arupctg001489_np121212120172420 andreaea_rupestris Arupctg001489_np121212120172420