PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL7015
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H48992
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL25914
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT14219
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR5065
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS13433
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR5870
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Algae (388) Bryophytes (9418) Lycophytes/Ferns (423) Gymnosperms (1285) Basal angiosperms (2118) Monocots (23710) Eudicots (83094)
Algae
Hits388
Bryophytes
Hits9418
Lycophytes/Ferns
Hits423
Gymnosperms
Hits1285
Basal angiosperms
Hits2118
Monocots
Hits23710
Eudicots
Hits83094
Species Distribution
Triticum turgidum
Aegilops tauschii
Hordeum vulgare
Triticum aestivum
Prunus domestica
Ocimum basilicum
Avena sativa
Papaver setigerum
Pogostemon cablin
Fragaria ananassa
Lineage Summary
Algae
388
Bryophytes
9418
Lycophytes/Ferns
423
Gymnosperms
1285
Basal angiosperms
2118
Monocots
23710
Eudicots
83094
Module Gene List
GeneSpeciesProtein ID
Aalbaalba5_s000333060180520.1 abies_alba Aalbaalba5_s000333060180520.1
Aalbaalba5_s000345610185890.1 abies_alba Aalbaalba5_s000345610185890.1
Aalbaalba5_s000347230186640.1 abies_alba Aalbaalba5_s000347230186640.1
Aalbaalba5_s000387680204270.1 abies_alba Aalbaalba5_s000387680204270.1
Aalbaalba5_s000387960204380.1 abies_alba Aalbaalba5_s000387960204380.1
Aalbaalba5_s000387960204400.1 abies_alba Aalbaalba5_s000387960204400.1
Aalbaalba5_s000391520205800.1 abies_alba Aalbaalba5_s000391520205800.1
Aalbaalba5_s000418290217080.1 abies_alba Aalbaalba5_s000418290217080.1
Aalbaalba5_s000425440220250.1 abies_alba Aalbaalba5_s000425440220250.1
Aalbaalba5_s000450300230830.1 abies_alba Aalbaalba5_s000450300230830.1
Aalbaalba5_s000455930233080.1 abies_alba Aalbaalba5_s000455930233080.1
Aalbaalba5_s000480190243020.1 abies_alba Aalbaalba5_s000480190243020.1
Aalbaalba5_s000495500248770.1 abies_alba Aalbaalba5_s000495500248770.1
Aalbaalba5_s000496350249110.1 abies_alba Aalbaalba5_s000496350249110.1
Aalbaalba5_s000497820249780.1 abies_alba Aalbaalba5_s000497820249780.1
Aalbaalba5_s000505610252460.1 abies_alba Aalbaalba5_s000505610252460.1
Aalbaalba5_s000523610259280.1 abies_alba Aalbaalba5_s000523610259280.1
Aalbaalba5_s000558860272040.1 abies_alba Aalbaalba5_s000558860272040.1
Aalbaalba5_s000558860272040.2 abies_alba Aalbaalba5_s000558860272040.2
Aalbaalba5_s000580020279370.1 abies_alba Aalbaalba5_s000580020279370.1
Aalbaalba5_s000584420280660.1 abies_alba Aalbaalba5_s000584420280660.1
Aalbaalba5_s000603310287330.1 abies_alba Aalbaalba5_s000603310287330.1
Aalbaalba5_s000620360292670.1 abies_alba Aalbaalba5_s000620360292670.1
Aalbaalba5_s000623170293590.1 abies_alba Aalbaalba5_s000623170293590.1
Aalbaalba5_s000639460299580.1 abies_alba Aalbaalba5_s000639460299580.1
Aalbaalba5_s000675440310810.1 abies_alba Aalbaalba5_s000675440310810.1
Aalbaalba5_s000685610313960.1 abies_alba Aalbaalba5_s000685610313960.1
Aalbaalba5_s000694870316970.1 abies_alba Aalbaalba5_s000694870316970.1
Aalbaalba5_s000694870316970.2 abies_alba Aalbaalba5_s000694870316970.2
Aalbaalba5_s000702210319190.1 abies_alba Aalbaalba5_s000702210319190.1