PlantSME Plant secondary metabolism enzyme database
Rosmarinic acid portable pathway

Rosmarinic acid portable pathway

Category：Rosmarinic acid pathway

Rosmarinic acid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Rosmarinic Acid Reaction Route
Phenylalanine donor branch plus tyrosine acceptor branch. This pathway merges two aromatic amino-acid branches; after RAS condensation, CYP98A-type hydroxylases form rosmarinic acid with CPR electron-transfer support. The page displays annotatable members in the current reference library.
7 curated steps/modules
Phenylalanine Donor Branch
01
Substrate
L-Phenylalanine
C9H11NO2
C6H5-CH2-CH(NH2)-COOH
Deamination into the phenylpropanoid donor branch
PAL17675
Product
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
PAL converts L-phenylalanine to cinnamate as the entry step toward the 4-coumaroyl-CoA donor.
02
Substrate
trans-Cinnamic acid
C9H8O2
C6H5-CH=CH-COOH
Cinnamate 4-hydroxylation
C4H96445
Product
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
C4H/CYP73A forms 4-coumaric acid for downstream CoA activation.
03
Substrate
4-Coumaric acid
C9H8O3
4-HO-C6H4-CH=CH-COOH
Substrate
CoA
C21H36N7O16P3S
CoA-SH
CoA ligation to form the RAS acyl donor
4CL30481
Product
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
4CL generates 4-coumaroyl-CoA as the acyl donor for the RAS condensation reaction.
Tyrosine Acceptor Branch And Condensation
04
Substrate
L-Tyrosine
C9H11NO3
4-HO-C6H4-CH2-CH(NH2)-COOH
Transamination to 4-hydroxyphenylpyruvate
TAT36416
Product
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
TAT routes L-tyrosine into the 4-hydroxyphenylpyruvate acceptor branch.
05
Substrate
4-Hydroxyphenylpyruvate
C9H8O4
4-HO-C6H4-CH2-C(=O)-COOH
Reduction to the HPLA acceptor
HPPR14796
Product
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
HPPR reduces 4-hydroxyphenylpyruvate to 4-hydroxyphenyllactate.
06
Substrate
4-Coumaroyl-CoA
C30H38N7O18P3S
4-HO-C6H4-CH=CH-C(=O)-SCoA
Substrate
4-Hydroxyphenyllactate
C9H10O4
4-HO-C6H4-CH2-CH(OH)-COOH
Ester-forming condensation
RAS38618
Product
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
4-HO-C6H4-CH=CH-C(=O)-O-CH(COOH)-CH2-Ar-OH
RAS couples the acyl donor with the HPLA acceptor to form the direct rosmarinic-acid precursor.
07
Substrate
4-Coumaroyl-4'-hydroxyphenyllactate
C18H16O7
mono-catechol ester precursor
CYP98A14-type hydroxylation with CPR electron-transfer support
CPR12799
Product
Rosmarinic acid
C18H16O8
caffeoyl-O-3,4-dihydroxyphenyllactate
CYP98A14 or close CYP98A enzymes catalyse 3/3' hydroxylation; CPR in the current reference library represents electron-transfer support for this P450 reaction and should not be interpreted as CPR alone performing hydroxylation.
Lineage Distribution
Assignments under this module are distributed across the following plant lineages.
All Lineages Eudicots (247230)
Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.
Algae
Hits0
Bryophytes
Hits0
Lycophytes/Ferns
Hits0
Gymnosperms
Hits0
Basal angiosperms
Hits0
Monocots
Hits0
Eudicots
Hits247230
Species Distribution
Begonia fuchsioides
Fragaria ananassa
Chrysanthemum seticuspe
Diospyros kaki
Cajanus cajan
Gossypium tomentosum
Brassica carinata
Gossypium hirsutum
Gossypium mustelinum
Citrus limon
Lineage Summary
Eudicots
247230
Module Gene List
Reset
GeneSpeciesProtein ID
acacia_pycnantha_KAI9121177.1 acacia_pycnantha acacia_pycnantha_KAI9121177.1
acacia_pycnantha_KAI9121189.1 acacia_pycnantha acacia_pycnantha_KAI9121189.1
acacia_pycnantha_KAI9121294.1 acacia_pycnantha acacia_pycnantha_KAI9121294.1
acacia_pycnantha_KAI9121320.1 acacia_pycnantha acacia_pycnantha_KAI9121320.1
acacia_pycnantha_KAI9121332.1 acacia_pycnantha acacia_pycnantha_KAI9121332.1
acacia_pycnantha_KAI9121365.1 acacia_pycnantha acacia_pycnantha_KAI9121365.1
acacia_pycnantha_KAI9121475.1 acacia_pycnantha acacia_pycnantha_KAI9121475.1
acacia_pycnantha_KAI9121494.1 acacia_pycnantha acacia_pycnantha_KAI9121494.1
acacia_pycnantha_KAI9121916.1 acacia_pycnantha acacia_pycnantha_KAI9121916.1
acacia_pycnantha_KAI9121980.1 acacia_pycnantha acacia_pycnantha_KAI9121980.1
acacia_pycnantha_KAI9121981.1 acacia_pycnantha acacia_pycnantha_KAI9121981.1
acacia_pycnantha_KAI9122005.1 acacia_pycnantha acacia_pycnantha_KAI9122005.1
acacia_pycnantha_KAI9122036.1 acacia_pycnantha acacia_pycnantha_KAI9122036.1
acacia_pycnantha_KAI9122076.1 acacia_pycnantha acacia_pycnantha_KAI9122076.1
acacia_pycnantha_KAI9122079.1 acacia_pycnantha acacia_pycnantha_KAI9122079.1
acacia_pycnantha_KAI9122150.1 acacia_pycnantha acacia_pycnantha_KAI9122150.1
acacia_pycnantha_KAI9122182.1 acacia_pycnantha acacia_pycnantha_KAI9122182.1
acacia_pycnantha_KAI9122223.1 acacia_pycnantha acacia_pycnantha_KAI9122223.1
acacia_pycnantha_KAI9122234.1 acacia_pycnantha acacia_pycnantha_KAI9122234.1
acacia_pycnantha_KAI9122325.1 acacia_pycnantha acacia_pycnantha_KAI9122325.1
acacia_pycnantha_KAI9122354.1 acacia_pycnantha acacia_pycnantha_KAI9122354.1
acacia_pycnantha_KAI9122391.1 acacia_pycnantha acacia_pycnantha_KAI9122391.1
acacia_pycnantha_KAI9122674.1 acacia_pycnantha acacia_pycnantha_KAI9122674.1
acacia_pycnantha_KAI9122767.1 acacia_pycnantha acacia_pycnantha_KAI9122767.1
acacia_pycnantha_KAI9122804.1 acacia_pycnantha acacia_pycnantha_KAI9122804.1
acacia_pycnantha_KAI9122894.1 acacia_pycnantha acacia_pycnantha_KAI9122894.1
acacia_pycnantha_KAI9123330.1 acacia_pycnantha acacia_pycnantha_KAI9123330.1
acacia_pycnantha_KAI9123454.1 acacia_pycnantha acacia_pycnantha_KAI9123454.1
acacia_pycnantha_KAI9123487.1 acacia_pycnantha acacia_pycnantha_KAI9123487.1
acacia_pycnantha_KAI9123508.1 acacia_pycnantha acacia_pycnantha_KAI9123508.1