Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
andrographis_paniculata_XP_051118307.1	andrographis_paniculata	andrographis_paniculata_XP_051118307.1
andrographis_paniculata_XP_051118395.1	andrographis_paniculata	andrographis_paniculata_XP_051118395.1
andrographis_paniculata_XP_051118685.1	andrographis_paniculata	andrographis_paniculata_XP_051118685.1
andrographis_paniculata_XP_051119052.1	andrographis_paniculata	andrographis_paniculata_XP_051119052.1
andrographis_paniculata_XP_051119053.1	andrographis_paniculata	andrographis_paniculata_XP_051119053.1
andrographis_paniculata_XP_051119054.1	andrographis_paniculata	andrographis_paniculata_XP_051119054.1
andrographis_paniculata_XP_051119055.1	andrographis_paniculata	andrographis_paniculata_XP_051119055.1
andrographis_paniculata_XP_051120178.1	andrographis_paniculata	andrographis_paniculata_XP_051120178.1
andrographis_paniculata_XP_051120312.1	andrographis_paniculata	andrographis_paniculata_XP_051120312.1
andrographis_paniculata_XP_051120774.1	andrographis_paniculata	andrographis_paniculata_XP_051120774.1
andrographis_paniculata_XP_051122076.1	andrographis_paniculata	andrographis_paniculata_XP_051122076.1
andrographis_paniculata_XP_051123512.1	andrographis_paniculata	andrographis_paniculata_XP_051123512.1
andrographis_paniculata_XP_051123520.1	andrographis_paniculata	andrographis_paniculata_XP_051123520.1
andrographis_paniculata_XP_051123528.1	andrographis_paniculata	andrographis_paniculata_XP_051123528.1
andrographis_paniculata_XP_051123538.1	andrographis_paniculata	andrographis_paniculata_XP_051123538.1
andrographis_paniculata_XP_051123810.1	andrographis_paniculata	andrographis_paniculata_XP_051123810.1
andrographis_paniculata_XP_051123924.1	andrographis_paniculata	andrographis_paniculata_XP_051123924.1
andrographis_paniculata_XP_051124209.1	andrographis_paniculata	andrographis_paniculata_XP_051124209.1
andrographis_paniculata_XP_051124318.1	andrographis_paniculata	andrographis_paniculata_XP_051124318.1
andrographis_paniculata_XP_051124747.1	andrographis_paniculata	andrographis_paniculata_XP_051124747.1
andrographis_paniculata_XP_051125030.1	andrographis_paniculata	andrographis_paniculata_XP_051125030.1
andrographis_paniculata_XP_051125038.1	andrographis_paniculata	andrographis_paniculata_XP_051125038.1
andrographis_paniculata_XP_051125047.1	andrographis_paniculata	andrographis_paniculata_XP_051125047.1
andrographis_paniculata_XP_051125075.1	andrographis_paniculata	andrographis_paniculata_XP_051125075.1
andrographis_paniculata_XP_051125271.1	andrographis_paniculata	andrographis_paniculata_XP_051125271.1
andrographis_paniculata_XP_051125273.1	andrographis_paniculata	andrographis_paniculata_XP_051125273.1
andrographis_paniculata_XP_051125274.1	andrographis_paniculata	andrographis_paniculata_XP_051125274.1
andrographis_paniculata_XP_051125693.1	andrographis_paniculata	andrographis_paniculata_XP_051125693.1
andrographis_paniculata_XP_051125694.1	andrographis_paniculata	andrographis_paniculata_XP_051125694.1
andrographis_paniculata_XP_051125695.1	andrographis_paniculata	andrographis_paniculata_XP_051125695.1