Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
AedgHiC_scaffold_90263040	amphicarpaea_edgeworthii	AedgHiC_scaffold_90263040
AedgHiC_scaffold_90270330	amphicarpaea_edgeworthii	AedgHiC_scaffold_90270330
AedgHiC_scaffold_90276300	amphicarpaea_edgeworthii	AedgHiC_scaffold_90276300
andrographis_paniculata_XP_051113301.1	andrographis_paniculata	andrographis_paniculata_XP_051113301.1
andrographis_paniculata_XP_051113919.1	andrographis_paniculata	andrographis_paniculata_XP_051113919.1
andrographis_paniculata_XP_051113920.1	andrographis_paniculata	andrographis_paniculata_XP_051113920.1
andrographis_paniculata_XP_051113921.1	andrographis_paniculata	andrographis_paniculata_XP_051113921.1
andrographis_paniculata_XP_051113922.1	andrographis_paniculata	andrographis_paniculata_XP_051113922.1
andrographis_paniculata_XP_051113924.1	andrographis_paniculata	andrographis_paniculata_XP_051113924.1
andrographis_paniculata_XP_051113925.1	andrographis_paniculata	andrographis_paniculata_XP_051113925.1
andrographis_paniculata_XP_051113926.1	andrographis_paniculata	andrographis_paniculata_XP_051113926.1
andrographis_paniculata_XP_051113927.1	andrographis_paniculata	andrographis_paniculata_XP_051113927.1
andrographis_paniculata_XP_051113928.1	andrographis_paniculata	andrographis_paniculata_XP_051113928.1
andrographis_paniculata_XP_051113929.1	andrographis_paniculata	andrographis_paniculata_XP_051113929.1
andrographis_paniculata_XP_051113930.1	andrographis_paniculata	andrographis_paniculata_XP_051113930.1
andrographis_paniculata_XP_051113931.1	andrographis_paniculata	andrographis_paniculata_XP_051113931.1
andrographis_paniculata_XP_051113932.1	andrographis_paniculata	andrographis_paniculata_XP_051113932.1
andrographis_paniculata_XP_051113933.1	andrographis_paniculata	andrographis_paniculata_XP_051113933.1
andrographis_paniculata_XP_051113934.1	andrographis_paniculata	andrographis_paniculata_XP_051113934.1
andrographis_paniculata_XP_051114812.1	andrographis_paniculata	andrographis_paniculata_XP_051114812.1
andrographis_paniculata_XP_051116410.1	andrographis_paniculata	andrographis_paniculata_XP_051116410.1
andrographis_paniculata_XP_051116555.1	andrographis_paniculata	andrographis_paniculata_XP_051116555.1
andrographis_paniculata_XP_051116587.1	andrographis_paniculata	andrographis_paniculata_XP_051116587.1
andrographis_paniculata_XP_051116776.1	andrographis_paniculata	andrographis_paniculata_XP_051116776.1
andrographis_paniculata_XP_051117766.1	andrographis_paniculata	andrographis_paniculata_XP_051117766.1
andrographis_paniculata_XP_051118141.1	andrographis_paniculata	andrographis_paniculata_XP_051118141.1
andrographis_paniculata_XP_051118142.1	andrographis_paniculata	andrographis_paniculata_XP_051118142.1
andrographis_paniculata_XP_051118237.1	andrographis_paniculata	andrographis_paniculata_XP_051118237.1
andrographis_paniculata_XP_051118238.1	andrographis_paniculata	andrographis_paniculata_XP_051118238.1
andrographis_paniculata_XP_051118259.1	andrographis_paniculata	andrographis_paniculata_XP_051118259.1