Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
acacia_pycnantha_KAI9114842.1	acacia_pycnantha	acacia_pycnantha_KAI9114842.1
acacia_pycnantha_KAI9114886.1	acacia_pycnantha	acacia_pycnantha_KAI9114886.1
acacia_pycnantha_KAI9114949.1	acacia_pycnantha	acacia_pycnantha_KAI9114949.1
acacia_pycnantha_KAI9114988.1	acacia_pycnantha	acacia_pycnantha_KAI9114988.1
acacia_pycnantha_KAI9115063.1	acacia_pycnantha	acacia_pycnantha_KAI9115063.1
acacia_pycnantha_KAI9115126.1	acacia_pycnantha	acacia_pycnantha_KAI9115126.1
acacia_pycnantha_KAI9115148.1	acacia_pycnantha	acacia_pycnantha_KAI9115148.1
acacia_pycnantha_KAI9115555.1	acacia_pycnantha	acacia_pycnantha_KAI9115555.1
acacia_pycnantha_KAI9115654.1	acacia_pycnantha	acacia_pycnantha_KAI9115654.1
acacia_pycnantha_KAI9115657.1	acacia_pycnantha	acacia_pycnantha_KAI9115657.1
acacia_pycnantha_KAI9115662.1	acacia_pycnantha	acacia_pycnantha_KAI9115662.1
acacia_pycnantha_KAI9115663.1	acacia_pycnantha	acacia_pycnantha_KAI9115663.1
acacia_pycnantha_KAI9115808.1	acacia_pycnantha	acacia_pycnantha_KAI9115808.1
acacia_pycnantha_KAI9115817.1	acacia_pycnantha	acacia_pycnantha_KAI9115817.1
acacia_pycnantha_KAI9115831.1	acacia_pycnantha	acacia_pycnantha_KAI9115831.1
acacia_pycnantha_KAI9116340.1	acacia_pycnantha	acacia_pycnantha_KAI9116340.1
acacia_pycnantha_KAI9116359.1	acacia_pycnantha	acacia_pycnantha_KAI9116359.1
acacia_pycnantha_KAI9116370.1	acacia_pycnantha	acacia_pycnantha_KAI9116370.1
acacia_pycnantha_KAI9116442.1	acacia_pycnantha	acacia_pycnantha_KAI9116442.1
acacia_pycnantha_KAI9116469.1	acacia_pycnantha	acacia_pycnantha_KAI9116469.1
acacia_pycnantha_KAI9116639.1	acacia_pycnantha	acacia_pycnantha_KAI9116639.1
acacia_pycnantha_KAI9116659.1	acacia_pycnantha	acacia_pycnantha_KAI9116659.1
acacia_pycnantha_KAI9117604.1	acacia_pycnantha	acacia_pycnantha_KAI9117604.1
acacia_pycnantha_KAI9117611.1	acacia_pycnantha	acacia_pycnantha_KAI9117611.1
acacia_pycnantha_KAI9117645.1	acacia_pycnantha	acacia_pycnantha_KAI9117645.1
acacia_pycnantha_KAI9117869.1	acacia_pycnantha	acacia_pycnantha_KAI9117869.1
acacia_pycnantha_KAI9117882.1	acacia_pycnantha	acacia_pycnantha_KAI9117882.1
acacia_pycnantha_KAI9117890.1	acacia_pycnantha	acacia_pycnantha_KAI9117890.1
acacia_pycnantha_KAI9117929.1	acacia_pycnantha	acacia_pycnantha_KAI9117929.1
acacia_pycnantha_KAI9117956.1	acacia_pycnantha	acacia_pycnantha_KAI9117956.1