Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
acacia_pycnantha_KAI9118007.1	acacia_pycnantha	acacia_pycnantha_KAI9118007.1
acacia_pycnantha_KAI9118041.1	acacia_pycnantha	acacia_pycnantha_KAI9118041.1
acacia_pycnantha_KAI9118114.1	acacia_pycnantha	acacia_pycnantha_KAI9118114.1
acacia_pycnantha_KAI9118491.1	acacia_pycnantha	acacia_pycnantha_KAI9118491.1
acacia_pycnantha_KAI9118550.1	acacia_pycnantha	acacia_pycnantha_KAI9118550.1
acacia_pycnantha_KAI9118568.1	acacia_pycnantha	acacia_pycnantha_KAI9118568.1
acacia_pycnantha_KAI9118935.1	acacia_pycnantha	acacia_pycnantha_KAI9118935.1
acacia_pycnantha_KAI9119301.1	acacia_pycnantha	acacia_pycnantha_KAI9119301.1
acacia_pycnantha_KAI9119422.1	acacia_pycnantha	acacia_pycnantha_KAI9119422.1
acacia_pycnantha_KAI9119997.1	acacia_pycnantha	acacia_pycnantha_KAI9119997.1
acacia_pycnantha_KAI9120074.1	acacia_pycnantha	acacia_pycnantha_KAI9120074.1
acacia_pycnantha_KAI9120346.1	acacia_pycnantha	acacia_pycnantha_KAI9120346.1
acacia_pycnantha_KAI9120621.1	acacia_pycnantha	acacia_pycnantha_KAI9120621.1
acacia_pycnantha_KAI9120931.1	acacia_pycnantha	acacia_pycnantha_KAI9120931.1
acacia_pycnantha_KAI9121010.1	acacia_pycnantha	acacia_pycnantha_KAI9121010.1
acacia_pycnantha_KAI9121119.1	acacia_pycnantha	acacia_pycnantha_KAI9121119.1
acacia_pycnantha_KAI9121185.1	acacia_pycnantha	acacia_pycnantha_KAI9121185.1
acacia_pycnantha_KAI9122279.1	acacia_pycnantha	acacia_pycnantha_KAI9122279.1
acacia_pycnantha_KAI9122980.1	acacia_pycnantha	acacia_pycnantha_KAI9122980.1
acacia_pycnantha_KAI9123903.1	acacia_pycnantha	acacia_pycnantha_KAI9123903.1
acacia_pycnantha_KAI9124100.1	acacia_pycnantha	acacia_pycnantha_KAI9124100.1
acacia_pycnantha_KAI9124317.1	acacia_pycnantha	acacia_pycnantha_KAI9124317.1
acacia_pycnantha_KAI9124515.1	acacia_pycnantha	acacia_pycnantha_KAI9124515.1
acacia_pycnantha_KAI9124598.1	acacia_pycnantha	acacia_pycnantha_KAI9124598.1
acacia_pycnantha_KAI9124609.1	acacia_pycnantha	acacia_pycnantha_KAI9124609.1
acacia_pycnantha_KAI9125669.1	acacia_pycnantha	acacia_pycnantha_KAI9125669.1
acacia_pycnantha_KAI9127555.1	acacia_pycnantha	acacia_pycnantha_KAI9127555.1
acacia_pycnantha_KAI9127618.1	acacia_pycnantha	acacia_pycnantha_KAI9127618.1
acacia_pycnantha_KAI9127840.1	acacia_pycnantha	acacia_pycnantha_KAI9127840.1
acacia_pycnantha_KAI9127894.1	acacia_pycnantha	acacia_pycnantha_KAI9127894.1