Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
anisodus_acutangulus_KAJ8544676.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8544676.1
anisodus_acutangulus_KAJ8544850.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8544850.1
anisodus_acutangulus_KAJ8545063.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8545063.1
anisodus_acutangulus_KAJ8545631.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8545631.1
anisodus_acutangulus_KAJ8545886.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8545886.1
anisodus_acutangulus_KAJ8546227.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8546227.1
anisodus_acutangulus_KAJ8547328.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8547328.1
anisodus_acutangulus_KAJ8547356.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8547356.1
anisodus_acutangulus_KAJ8547546.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8547546.1
anisodus_acutangulus_KAJ8548152.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8548152.1
anisodus_acutangulus_KAJ8548864.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8548864.1
anisodus_acutangulus_KAJ8548987.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8548987.1
anisodus_acutangulus_KAJ8549223.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8549223.1
anisodus_acutangulus_KAJ8549266.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8549266.1
anisodus_acutangulus_KAJ8549454.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8549454.1
anisodus_acutangulus_KAJ8549605.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8549605.1
anisodus_acutangulus_KAJ8549686.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8549686.1
anisodus_acutangulus_KAJ8549798.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8549798.1
anisodus_acutangulus_KAJ8550060.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8550060.1
anisodus_acutangulus_KAJ8550867.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8550867.1
anisodus_acutangulus_KAJ8551140.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8551140.1
anisodus_acutangulus_KAJ8551599.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8551599.1
anisodus_acutangulus_KAJ8551600.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8551600.1
anisodus_acutangulus_KAJ8552667.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8552667.1
anisodus_acutangulus_KAJ8553084.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8553084.1
anisodus_acutangulus_KAJ8553510.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8553510.1
anisodus_acutangulus_KAJ8553765.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8553765.1
anisodus_acutangulus_KAJ8555108.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8555108.1
anisodus_acutangulus_KAJ8555278.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8555278.1
anisodus_acutangulus_KAJ8555660.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8555660.1