Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
anisodus_acutangulus_KAJ8555663.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8555663.1
anisodus_acutangulus_KAJ8557548.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8557548.1
anisodus_acutangulus_KAJ8557550.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8557550.1
anisodus_acutangulus_KAJ8557651.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8557651.1
anisodus_acutangulus_KAJ8558406.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8558406.1
anisodus_acutangulus_KAJ8558471.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8558471.1
anisodus_acutangulus_KAJ8558472.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8558472.1
anisodus_acutangulus_KAJ8559313.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8559313.1
anisodus_acutangulus_KAJ8559403.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8559403.1
anisodus_acutangulus_KAJ8559405.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8559405.1
anisodus_acutangulus_KAJ8559513.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8559513.1
anisodus_acutangulus_KAJ8559711.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8559711.1
anisodus_acutangulus_KAJ8560012.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8560012.1
anisodus_acutangulus_KAJ8560298.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8560298.1
anisodus_acutangulus_KAJ8560473.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8560473.1
anisodus_acutangulus_KAJ8560618.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8560618.1
anisodus_acutangulus_KAJ8560727.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8560727.1
anisodus_acutangulus_KAJ8560812.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8560812.1
anisodus_acutangulus_KAJ8560939.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8560939.1
anisodus_acutangulus_KAJ8561430.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8561430.1
anisodus_acutangulus_KAJ8562154.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8562154.1
anisodus_acutangulus_KAJ8562180.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8562180.1
anisodus_acutangulus_KAJ8562640.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8562640.1
anisodus_acutangulus_KAJ8563506.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8563506.1
anisodus_acutangulus_KAJ8563730.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8563730.1
anisodus_acutangulus_KAJ8564491.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8564491.1
anisodus_acutangulus_KAJ8564526.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8564526.1
anisodus_acutangulus_KAJ8565050.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8565050.1
anisodus_acutangulus_KAJ8565154.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8565154.1
anisodus_acutangulus_KAJ8565310.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8565310.1