Steroid portable pathway

Steroid pathway definition imported from the 2026-05-17 portable BLAST/HMM package.

Representative Steroid Reaction Route

Squalene to phytosterols and brassinosteroid branch. The steroid route starts from triterpenoid precursors, proceeds through squalene, 2,3-oxidosqualene, and cycloartenol, and then branches toward phytosterols and brassinosteroids; long branches are shown as curated modules.

3 curated steps/modules

Sterol Scaffold Formation

Substrate

Farnesyl diphosphate

C₁₅H₂₈O₇P₂

C₁₅ prenyl-OPP

Squalene synthesis, epoxidation, and cyclization

SQS/FDFT13441 SQE4023 CAS46700

Product

Cycloartenol

C₃₀H₅₀O

tetracyclic sterol nucleus with cyclopropyl side

SQS/SQE/CAS convert FPP-derived linear triterpenes into the plant sterol core.

Substrate

Cycloartenol-series intermediates

C₂₈-C₃₀ sterols

tetracyclic sterol nucleus

Demethylation, reduction, and side-chain remodeling

SMT1/SMT2/SMT324927 SMO1/SMO26895 CPI1777 CYP51G14290 FK858 HYD1962 DWF76507 DWF5271 DWF11016

Product

Phytosterols

C₂₈H₄₈O / C₂₉H₅₀O

sterol nucleus-C₈/C₉ side chain

This segment converts cycloartenol-series intermediates into phytosterol pools such as sitosterol and campesterol.

Brassinosteroid Branch

Substrate

Campesterol-like sterols

C₂₈H₄₈O

sterol nucleus-C₈ side chain

Sterol hydroxylation/oxidation to brassinosteroids

DET22338 DWF4/CYP90B12383 CPD/CYP90A12379 ROT3/CYP90C1396 CYP90D167 BR6OX1/CYP85A1120 BR6OX2/CYP85A265

Product

Brassinosteroids

C₂₈ oxygenated lactones

polyhydroxylated steroid lactone

DET2 and CYP90/CYP85 enzymes route campesterol-like substrates toward brassinosteroid signaling molecules.

Lineage Distribution

Assignments under this module are distributed across the following plant lineages.

All Lineages Eudicots (108415)

Current lineage filter: Eudicots. All species, family, module, and gene statistics below have been narrowed to this lineage.

Species Distribution

Chrysanthemum seticuspe

Dianthus caryophyllus

Lineage Summary

Module Gene List

Gene	Species	Protein ID
anisodus_acutangulus_KAJ8565508.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8565508.1
anisodus_acutangulus_KAJ8565601.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8565601.1
anisodus_acutangulus_KAJ8565777.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8565777.1
anisodus_acutangulus_KAJ8566108.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8566108.1
anisodus_acutangulus_KAJ8567130.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8567130.1
anisodus_acutangulus_KAJ8567459.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8567459.1
anisodus_acutangulus_KAJ8568704.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8568704.1
anisodus_acutangulus_KAJ8569653.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8569653.1
anisodus_acutangulus_KAJ8569929.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8569929.1
anisodus_acutangulus_KAJ8570193.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8570193.1
anisodus_acutangulus_KAJ8570850.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8570850.1
anisodus_acutangulus_KAJ8571018.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8571018.1
anisodus_acutangulus_KAJ8572145.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8572145.1
anisodus_acutangulus_KAJ8572226.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8572226.1
anisodus_acutangulus_KAJ8572338.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8572338.1
anisodus_acutangulus_KAJ8572491.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8572491.1
anisodus_acutangulus_KAJ8572549.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8572549.1
anisodus_acutangulus_KAJ8572741.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8572741.1
anisodus_acutangulus_KAJ8572742.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8572742.1
anisodus_acutangulus_KAJ8572744.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8572744.1
anisodus_acutangulus_KAJ8573176.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8573176.1
anisodus_acutangulus_KAJ8573304.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8573304.1
anisodus_acutangulus_KAJ8573380.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8573380.1
anisodus_acutangulus_KAJ8573586.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8573586.1
anisodus_acutangulus_KAJ8573604.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8573604.1
anisodus_acutangulus_KAJ8573605.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8573605.1
anisodus_acutangulus_KAJ8573606.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8573606.1
anisodus_acutangulus_KAJ8573607.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8573607.1
anisodus_acutangulus_KAJ8574103.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8574103.1
anisodus_acutangulus_KAJ8574269.1	anisodus_acutangulus	anisodus_acutangulus_KAJ8574269.1